CAS 1264-72-8

solfato di colistina

Descrizione:

solfato di colistina, con il numero CAS 1264-72-8, è un antibiotico che appartiene alla classe degli antibiotici polimixina, utilizzato principalmente per trattare infezioni causate da batteri Gram-negativi. È derivato dal batterio Bacillus polymyxa ed è noto per la sua efficacia contro ceppi multiresistenti. solfato di colistina è una miscela complessa di polipeptidi, con colistina A e colistina E come componenti più prominenti. La sostanza è caratterizzata dalla sua natura anfipatica, che le consente di interrompere le membrane cellulari batteriche, portando alla morte cellulare. solfato di colistina viene tipicamente somministrato per iniezione o inalazione, poiché è scarsamente assorbito dal tratto gastrointestinale. Il suo utilizzo è stato limitato a causa della potenziale nefrotossicità e neurotossicità, richiedendo un attento monitoraggio durante il trattamento. Nonostante queste preoccupazioni, solfato di colistina ha riacquistato attenzione negli ultimi anni a causa dell'aumento delle infezioni resistenti agli antibiotici, rendendolo un'opzione critica nell'arsenale antimicrobico. La sua formulazione come sale solfato ne migliora la solubilità e stabilità, facilitando il suo utilizzo in contesti clinici.

Formula: (C₅₂H₉₈N₁₆O₁₃)·5(H₂SO₄)

InChI: InChI=1/C52H98N16O13/c1-9-29(6)11-10-12-40(71)59-32(13-19-53)47(76)68-42(31(8)70)52(81)64-35(16-22-56)44(73)63-37-18-24-58-51(80)41(30(7)69)67-48(77)36(17-23-57)61-43(72)33(14-20-54)62-49(78)38(25-27(2)3)66-50(79)39(26-28(4)5)65-45(74)34(15-21-55)60-46(37)75/h27-39,41-42,69-70H,9-26,53-57H2,1-8H3,(H,58,80)(H,59,71)(H,60,75)(H,61,72)(H,62,78)(H,63,73)(H,64,81)(H,65,74)(H,66,79)(H,67,77)(H,68,76)/t29?,30-,31-,32+,33+,34+,35+,36+,37+,38+,39-,41+,42+/m1/s1

Sinonimi:

• Belcomycin
• Colimycin sulfate
• Colistin Sulphate
• Colistin, Sulfat (Salz)
• Colistin, sulfate (salt)
• Colistina, Sulfato (Sal)
• Colistine, Sulfate (Sel)
• Colomycin
• Colomycin syrup
• N-[(1S)-3-amino-1-{[(1S,2R)-1-{[(1S)-3-amino-1-{[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl]carbamoyl}-2-hydroxypropyl]carbamoyl}propyl]-5-methylheptanamide
• N-[(2S)-4-amino-1-{[(2S,3R)-1-{[(2S)-4-amino-1-oxo-1-{[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]amino}butan-2-yl]amino}-3-hydroxy-1-oxobutan-2-yl]amino}-1-oxobutan-2-yl]-6-methyloctanamide sulfate (1:1)
• N-[3-Amino-1-[[1-[[3-Amino-1-[[6,9,18-Tris(2-Aminoethyl)-3-(1-Hydroxyethyl)-12,15-Bis(2-Methylpropyl)-2,5,8,11,14,17,20-Heptaoxo-1,4,7,10,13,16,19-Heptazacyclotricos-21-Yl]Carbamoyl]Propyl]Carbamoyl]-2-Hydroxy-Propyl]Carbamoyl]Propyl]-5-Methyl-Heptanamide Sulfate
• Nipoxyme
• Polymyxin E sulfate
• Polymyxin E, sulfate (salt)
• Colistin sulfate
• COLISTIN SULPHATE PURE GRADE
• polymyxine Multimycine
• Colistin sulphate premix 10% 40%
• polymyxinesulfate(salt)
• Colstin sulfate
• colistinsulfat
• Belcomycine
• colomycinsyrup
• COLISTINSULFATE,POWDER,USP
• colimycinsulfate
• COLISTINE SULFATE
• Colistin sulphate premix 10%
• ColistinSulfateEp5
• Colomyci

Colistin sulfate

CAS: 1264-72-8

Colistin sulfate, 1264-72-8, or polymyxin E complex, is a complex of antibiotics, primarily colistin A and B, which has broad-spectrum anti-bacterial activity. Learn more.

Formula: C₅₃H₁₀₂N₁₆O₁₇S

Colore e forma: Powder, White to pale cream

Peso molecolare: 1267.55

Ref: 02-J60915

COLISTIN SULFATE FOR MICROBIOLOGICAL ASSAY CRS

CAS: 1264-72-8

COLISTIN SULFATE FOR MICROBIOLOGICAL ASSAY CRS

Formula: C₅₂H₉₈N₁₆O₁₃

Peso molecolare: 1155.434

Ref: 41-C2700000

Colistin Sulfate

CAS: 1264-72-8

Antibiotics nesoi

Formula: ColistinAC₅₃H₁₀₀N₁₆O₁₃ColistinBC₅₂H₉₈N₁₆O₁₃

Colore e forma: White Light Yellow Powder

Peso molecolare: 1155.434

Ref: 45-1148001

Colistin (sulfate)

CAS: 1264-72-8

Formula: C₅₃H₁₀₂N₁₆O₁₇S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 1267.5390

Ref: IN-DA000SQS

Colistin sulfate

CAS: 1264-72-8

Colistin sulfate (Colistin sulfate (1066-17-7 free base)) is a cyclic polypeptide antibiotic from Bacillus colistinus, composed of Polymyxins E1 and E2.

Formula: C₅₃H₁₀₀N₁₆O₁₇S

Purezza: 98%

Colore e forma: Powder

Peso molecolare: 1253.51

Ref: TM-T1245

Colistin sulfate

CAS: 1264-72-8

Colistin sulfate

Purezza: ≥95%

Peso molecolare: 1253.51g/mol

Ref: 54-BUP17364

Colistin sulfate salt

CAS: 1264-72-8

Purezza: ≥ 19000U/mg (dried basis)

Colore e forma: White to pale yellow, hygroscopic powder

Ref: 7W-GA9867

Colistin A Pentatrifluoroacetate (Polymyxin E1 Pentatrifluoroacetate)

CAS: 1264-72-8, 7722-44-3

Formula: C₅₃H₁₀₀N₁₆O₁₃·5C₂HF₃O₂

Peso molecolare: 1169.48 5*114.02

Ref: 4Z-PC-321002

Colistin sulfate salt, Ph. Eur. grade

CAS: 1264-72-8

Purezza: ≤ 4.0%

Colore e forma: White or almost white powder

Ref: 7W-GP4890

Colistin sulphate

CAS: 1264-72-8

Colistin sulphate

Formula: C₅₃H₁₀₀N₁₆O₁₃·H₂SO₄

Purezza: Sulphate: 17.2%; sulphated (Typical Value in Batch COA)

Colore e forma: Solid

Peso molecolare: 1,267.54g/mol

Ref: 54-BIC0118

Colistin sulfate

Prodotto controllato

CAS: 1264-72-8

Formula: CompoundAC₅₃H₁₀₀N₁₆O₁₃·(H₂SO₄)CompoundBCH₉₈N₁₆O₁₃·(H₂SO₄)

Colore e forma: Neat

Peso molecolare: 1169.46

Ref: 04-C11693500

Colistin sulfate 100 µg/mL in Water

Prodotto controllato

CAS: 1264-72-8

Formula: CompoundAC₅₃H₁₀₀N₁₆O₁₃·(H₂SO₄)CompoundBCH₉₈N₁₆O₁₃·(H₂SO₄)

Colore e forma: Colourless

Peso molecolare: 1169.46

Ref: 04-A11693500WA-100

Colistin Sulfate (Mixture of A and B compound)

CAS: 1264-72-8

Ref: 4Z-PC-321001

Colistin Sulfate (Mixture of A and B compound)

Prodotto controllato

CAS: 1264-72-8

Applications Cyclic polypeptide antibiotic produced by Bacillus polymyxa. Complex mixture of at least 30 components, primarily colistins A and B.[α]D= -65° (c= 1, Water) LOD: 3% DAB= α,γ-diaminobutyric acidHeavy Metals: 20ppm Colistin A R= (+)-6-methyloctanoylArsenic Content: 2ppm/g Colistin B R= 6-methylheptanoylSulfate: 16-18%Biological Potency (dry basis): 19600U/mg
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Suzuki, T., et al.: J. Biochem., 54, 25 (1963), Barnett, M., et al.: Br. J. Pharmacol. Chemother., 23, 552 (1964), Littlewood, J, M., et al.: Respir. Med., 94, 632 (2000), Li, J., et al.: Int. J. Antimicrob. Ag., 25, 11 (2005),

Formula: CompoundAC₅₃H₁₀₀N₁₆O₁₃·(H₂SO₄)CompoundBC₅₂H₉₈N₁₆O₁₃·(H₂SO₄)

Colore e forma: White To Light Yellow

Peso molecolare: 1169.46

Ref: TR-C641500

Colistin sulfate

CAS: 1264-72-8

Colistin is a narrow-spectrum antibiotic efficient mostly against gram-negative bacteria. Colistin interacts with the outer membrane of gram-negative bacteria and induces a transfer of divalent cations of calcium and magnesium from the negatively charged phosphate groups. This causes the disruption of the outer membrane and release of lipopolysaccharides. It is commonly used against Enterobacteriaceae and Aeromonas, and none-fermentative gram-negative bacteria as well as for carbapenem-resistant Acinetobacter strains.

Formula: C₅₃H₁₀₂N₁₆O₁₇S

Purezza: Min. 77 Area-%

Colore e forma: White Powder

Peso molecolare: 1,266.73 g/mol

Ref: 3D-AC20542

Colistin sulfate, Antibiotic for Culture Media Use Only

CAS: 1264-72-8

Antibacterial agent with the ability to permeate bacterial membranes and cause cell death. Colistin is a cationic peptide also known as polymyxin E. Colistin is effective in multidrug resistant Gram-positive bacteria such as P. aeruginosa, A. baumannii and K. pneumoniae.

Formula: C₅₃H₁₀₂N₁₆O₁₇S

Peso molecolare: 1,266.73 g/mol

Ref: 3D-Q-200890

Colistin Sulphate (CLS)

CAS: 1264-72-8

Formula: (C₅₂H₉₈N₁₆O₁₃)·5(H₂SO₄)

Colore e forma: White to pale yellow, Crystalline powder

Peso molecolare: 2801.27

Ref: SR-51681