CAS 127-07-1

Idrossiurea

Descrizione:

Idrossiurea, con il numero CAS 127-07-1, è un composto chimico che funge da agente antineoplastico, utilizzato principalmente nel trattamento di alcuni tumori, come la leucemia mieloide cronica e i tumori della testa e del collo, oltre a essere impiegato nella gestione della malattia delle cellule falciformi. È un solido cristallino bianco solubile in acqua e presenta una formula molecolare di C₄H₈N₂O₂. Idrossiurea agisce come inibitore della ribonucleotide reduttasi, interrompendo la sintesi del DNA impedendo la conversione dei ribonucleotidi in desossiribonucleotidi, inibendo così la proliferazione cellulare. Il composto è anche noto per la sua capacità di aumentare i livelli di emoglobina fetale nei pazienti con malattia delle cellule falciformi, il che può ridurre la frequenza delle crisi dolorose. Idrossiurea viene tipicamente somministrato per via orale e può avere effetti collaterali, tra cui mielosoppressione, disturbi gastrointestinali e potenziali effetti teratogeni, richiedendo un attento monitoraggio durante il trattamento. Il suo meccanismo d'azione e le applicazioni terapeutiche lo rendono un agente significativo in oncologia e ematologia.

Formula: CH₄N₂O₂

InChI: InChI=1/CH4N2O2/c2-1(4)3-5/h3H2,(H2,2,4)

InChI key: InChIKey=VSNHCAURESNICA-UHFFFAOYSA-N

SMILES: C(NO)(N)=O

Sinonimi:

• 1-Hydroxyurea
• Amino(Oxido-Λ5-Azanyl)Methanone
• Biosupressin
• Carbamohydroxamic acid
• Carbamohydroximic acid
• Carbamoyl oxime
• Carbamyl hydroxamate
• Cytodrox
• Droxia
• HU
• Hidrix
• Hidroxicarbamida
• Hydrea
• Hydreia
• Hydrixycarbamide
• Hydroxy Urea (D4)
• Hydroxy urea
• Hydroxycarbamid
• Hydroxycarbamide
• Hydroxycarbamine
• Hydroxylamine, N-(aminocarbonyl)-
• Hydroxylurea
• Hydura
• Hydurea
• Litaler
• Litalir
• Mylocel
• N-(aminocarbonyl)hydroxylamine
• N-Carbamoylhydroxylamine
• N-Hydroxyharnstoff
• N-Hydroxyurea
• Nci C04831
• Nsc 32065
• Onco-carbide
• Oxyrea
• Oxyurea
• Siklos
• Sk 22591
• Sq 1089
• Urea, N-hydroxy-
• Urea, hydroxy-
• Wr 83799
• Xromi
• hydroxyharnstoff
• carbamylhydroxamate
• Carbamoylhydroxylamine
• carbamohydroxyamicacid
• carbamohydroxamicacid
• hydroxy-ure
• HYDROXYUREA
• carbamoyloxime

Hydroxyurea

CAS: 127-07-1

Formula: CH₄N₂O₂

Purezza: >97.0%(HPLC)(N)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 76.06

Ref: 3B-H0310

Hydroxyurea, 98%

CAS: 127-07-1

Hydroxyurea is used as an inhibitor of DNA synthesis and an anti-cancer drug. It is used as a precursor to prepare 1-hydroxy-5,6-dimethyl-1H-pyrimidine-2,4-dione via reaction with 2-methyl-3-oxo-butyric acid ethyl ester. It is used in the treatment of melanoma, resistant chronic myelocytic leukemia

Formula: CH₄N₂O₂

Purezza: 98%

Colore e forma: White to cream or yellow, Crystals or powder or crystalline powder

Peso molecolare: 76.06

Ref: 02-A10831

HYDROXYCARBAMIDE CRS

CAS: 127-07-1

HYDROXYCARBAMIDE CRS

Formula: CH₄N₂O₂

Colore e forma: Crystalline Powder. White. Powder.

Peso molecolare: 76.0547

Ref: 41-Y0000119

Hydroxycarbamide

CAS: 127-07-1

Hydroxycarbamide

Formula: CH₄N₂O₂

Purezza: 99.6%

Colore e forma: Off-White

Peso molecolare: 76.02728

Ref: 47-197

Hydroxyurea

CAS: 127-07-1

Non-aromatic organic derivatives of hydrazine or of hydroxylamine for use as drugs

Formula: CH₄N₂O₂

Colore e forma: White Off-White Powder

Peso molecolare: 76.06 g/mol

Ref: 45-1332000

Urea, N-hydroxy-

CAS: 127-07-1

Formula: CH₄N₂O₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 76.0547

Ref: IN-DA000WIJ

Hydroxyurea

CAS: 127-07-1

Hydroxyurea (Hydroxycarbamide), an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.

Formula: CH₄N₂O₂

Purezza: 99.85% - 99.92%

Colore e forma: Solid

Peso molecolare: 76.05

Ref: TM-T0676

Hydroxyurea

CAS: 127-07-1

Formula: CH₄N₂O₂

Purezza: 98.0 - 102.0 % (anhydrous basis)

Colore e forma: White to off-white powder

Peso molecolare: 76.06

Ref: 7W-GP0795

Hydroxyurea

CAS: 127-07-1

Hydroxyurea

Purezza: ≥98%

Peso molecolare: 76.05g/mol

Ref: 54-BUP18378

Hydroxy Urea

CAS: 127-07-1

Formula: CH₄N₂O₂

Peso molecolare: 76.06

Ref: 4Z-U-061

Hydroxyurea

CAS: 127-07-1

Hydroxyurea

Formula: CH₄N₂O₂

Purezza: 98%

Colore e forma: white solid

Peso molecolare: 76.05g/mol

Ref: 54-BIH0153

1-Hydroxyurea

CAS: 127-07-1

1-Hydroxyurea

Purezza: 98%

Peso molecolare: 76.05g/mol

Ref: 54-OR9108

Hydroxy Urea

Prodotto controllato

CAS: 127-07-1

Stability Hygroscopic
Applications An anti-neoplastic - inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide.
References Ratcliffe, W., et al.: Lancet, 339, 164 (1992), Roodman, G., et al.: Cancer, 80, 1557 (1997), Horwitz, M., et al.: J. Clin. Endocrinol. Metab., 2003, 88, 1603 (2003),

Formula: CH₄N₂O₂

Colore e forma: White Solid

Peso molecolare: 76.05

Ref: TR-H991000

Hydroxy Urea

CAS: 127-07-1

Formula: CH₄N₂O₂

Peso molecolare: 76.06

Ref: ST-EA-CP-F32011

Hydroxyurea

CAS: 127-07-1

Hydroxyurea is a prodrug that is activated by the enzyme Jak2, which is found in the mitochondria of cells. Hydroxyurea is used to treat various types of cancer and other diseases, such as sickle cell anemia. It has been shown to be effective in inhibiting the growth of squamous cell carcinomas and myeloid leukemia cells. Hydroxyurea has also been shown to have synergistic effects when combined with other pharmacological agents, such as hydroxycarbamide and cytosine arabinoside. Hydroxyurea inhibits the production of energy in the form of ATP, which leads to death by apoptosis or necrosis. This drug also has inhibitory properties against bacterial infections, especially those caused by Mycobacterium tuberculosis and Mycobacterium avium complex.

Formula: CH₄N₂O₂

Purezza: Min. 97.5 Area-%

Colore e forma: White Off-White Powder

Peso molecolare: 76.06 g/mol

Ref: 3D-FH09735

Hydroxyurea

CAS: 127-07-1

Formula: CH₄N₂O₂

Purezza: 98%

Colore e forma: Solid, White crystalline powder

Peso molecolare: 76.055

Ref: 10-F043351