CAS 127134-13-8

DABCYL-GAMMA-ABU-SER-GLN-ASN-TYR-PRO-ILE-VAL-GLN-EDANS

Descrizione:

DABCYL-GAMMA-ABU-SER-GLN-ASN-TYR-PRO-ILE-VAL-GLN-EDANS è un composto chimico a base di peptidi comunemente utilizzato nella ricerca biochimica, in particolare nelle applicazioni di trasferimento di energia da risonanza di fluorescenza (FRET). Questo composto è costituito da un donatore (EDANS) e un accettore (DABCYL), separati da una sequenza peptidica. La presenza di questi due fluorofori consente lo studio delle interazioni molecolari e dei cambiamenti conformazionali nelle proteine o negli acidi nucleici. La sequenza peptidica include vari amminoacidi, contribuendo alle sue proprietà strutturali e funzionali. DABCYL agisce come un quenchers, assorbendo energia dallo stato eccitato di EDANS, che emette fluorescenza quando non è in prossimità del quenchers. La stabilità e la solubilità di questo composto sono influenzate dalla composizione specifica degli amminoacidi e dalla struttura complessiva del peptide. Le sue applicazioni si estendono al monitoraggio dell'attività enzimatica, allo studio del ripiegamento delle proteine e all'indagine dei processi cellulari, rendendolo uno strumento prezioso nella biologia molecolare e nella biochimica.

Formula: C₇₃H₉₇N₁₇O₁₈S

Sinonimi:

• 4-(4-Dimethylaminophenylazo)Benzoyl-Gamma-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-5-[(2-Aminoethyl)Amino]-Naphthalene-1-Sulfonic Acid
• Hiv Protease Fret Substrate I
• Dabcyl-Gaba-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Edans
• DABCYL-GAMMA-ABU-SER-GLN-ASN-TYR-PRO-ILE-VAL-GLN-EDANS
• DABCYL-γ-Abu-SQNYPIVQ-EDANS
• DABCYL-gamma-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS trifluoroacetate salt
• L-Glutamamide,N-[4-[[4-[[4-(dimethylamino)phenyl]azo]benzoyl]amino]-1-oxobutyl]-L-seryl-L-glutaminyl-L-asparaginyl-L-tyrosyl-L-prolyl-L-isoleucyl-L-valyl-N1-[2-[(5-sulfo-1-naphthalenyl)amino]ethyl]-
• DABCYL-γ-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS trifluoroacetate salt
• DABCYL-g-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS

DABCYL-γ-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS

CAS: 127134-13-8

The fluorogenic HIV-1 protease substrate DABCYL-Gaba-SQNYPIVQ-EDANS consists of an octapeptide with a fluorescent donor (EDANS) and a quenching acceptor (DABCYL), attached at the COOH- and NH₂-termini. The γ-Abu spacer was inserted to avoid potential steric hindrance of substrate binding by the bulky acceptor. This FRET substrate is cleaved by the HIV-1 protease at the Tyr-Pro bond which results in a time-dependent increase in fluorescence intensity; excitation at 340 nm, emission at 490 nm.

Formula: C₇₃H₉₇N₁₇O₁₈S

Purezza: > 95%

Peso molecolare: 1532.74

Ref: 01-4030716

Dabcyl-γ-abu-ser-gln-asn-tyr-pro-ile-val-gln-edans trifluoroacetate salt

CAS: 127134-13-8

Formula: C₇₃H₉₇N₁₇O₁₈S

Peso molecolare: 1532.7194

Ref: IN-DA000WPO

Dabcyl-γ-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Edans

CAS: 127134-13-8

Dabcyl-γ-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Edans is a bifunctional peptide that inhibits HIV protease. The peptide binds to the active site of the enzyme and blocks access to the catalytic triad, inhibiting its function. This peptide has been shown to inhibit viral life in human cells infected with HIV type 1 (HIV1), as well as virions, which are released into the bloodstream. Dabcyl is a small molecule inhibitor of HIV1 protease that also inhibits cellular proteases. It has been shown to inhibit viral life in human T cell lines (THP1) and other cells infected with HIV type 1 (HIV1).

Formula: C₇₃H₉₇N₁₇O₁₈S

Purezza: Min. 95%

Peso molecolare: 1,532.75 g/mol

Ref: 3D-SFQ-3763-PI

DABCYL-γ-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS trifluoroacetate salt

CAS: 127134-13-8

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Formula: C₇₃H₉₇N₁₇O₁₈S

Purezza: Min. 95%

Peso molecolare: 1,532.72 g/mol

Ref: 3D-FD110893