CAS 127852-28-2

(αR)-α-Metil-3,5-bis(trifluorometil)benzenometanolo

Descrizione:

(αR)-α-Metil-3,5-bis(trifluorometil)benzenometanolo, identificato dal suo numero CAS 127852-28-2, è un composto chimico caratterizzato dalla sua struttura unica, che include un anello benzenico sostituito da due gruppi trifluorometilici e un gruppo idrossimetilico. La presenza dei gruppi trifluorometilici influisce significativamente sulle sue proprietà chimiche, conferendo alta lipofilia e alterando la sua reattività rispetto agli analoghi non fluorurati. Questo composto probabilmente mostrerà forti interazioni intermolecolari a causa degli atomi di fluoro elettronegativi, il che può migliorare la sua stabilità e solubilità nei solventi organici. Inoltre, la stereochimica indicata dalla configurazione (αR) suggerisce che il composto possa mostrare una specifica attività ottica, che può essere rilevante in applicazioni come prodotti farmaceutici o agrochimici. In generale, la combinazione dei suoi gruppi funzionali e della stereochimica rende (αR)-α-Metil-3,5-bis(trifluorometil)benzenometanolo un composto di interesse in varie ricerche chimiche e applicazioni industriali.

Formula: C₁₀H₈F₆O

InChI: InChI=1S/C10H8F6O/c1-5(17)6-2-7(9(11,12)13)4-8(3-6)10(14,15)16/h2-5,17H,1H3/t5-/m1/s1

InChI key: InChIKey=MMSCIQKQJVBPIR-RXMQYKEDSA-N

SMILES: C(F)(F)(F)C1=CC(C(F)(F)F)=CC([C@@H](C)O)=C1

Sinonimi:

• (1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethan-1-ol
• (1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethanol
• (R)-1-(3,5-Bis(Trifluoromethyl)Phenyl)Ethan-1-Ol
• (R)-1-(3,5-Bis-trifluoromethylphenyl)ethanol
• (R)-1-3,5-Bis(trifluoromethyl) phenylethanol
• (R)-1-[3,5-Bis(Trifluoro-Methyl)-Phenyl]Ethanol
• (R)-1-[Bis-3,5-(Trifluoromethyl)Phenyl]Ethanol
• (R)-[3,5-Bis(trifluoromethyl)phenyl]ethanol
• (R)-bis-3,5-trifluoromethyl-1-phenylethanol
• (αR)-α-Methyl-3,5-bis(trifluoromethyl)benzenemethanol
• 1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethanol
• 1R)-1-[3,6-Bis(Trifluoromethyl)Phenyl]Ethanol
• Aprepitant Intermediate
• Benzenemethanol, A-Methyl-3,5-Bis(Trifluoromethyl)-, (Ar)-
• Benzenemethanol,a-methyl-3,5-bis(trifluoromethyl)-,(R)-
• R-Mbt-Pel

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol

CAS: 127852-28-2

Formula: C₁₀H₈F₆O

Purezza: >98.0%(GC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 258.16

Ref: 3B-B4131

Benzenemethanol, α-methyl-3,5-bis(trifluoromethyl)-, (αR)-

CAS: 127852-28-2

Formula: C₁₀H₈F₆O

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 258.1603

Ref: IN-DA000XGX

(1R)-(+)-1-[3,5-Bis(trifluoromethyl)phenyl]ethan-1-ol

CAS: 127852-28-2

(1R)-(+)-1-[3,5-Bis(trifluoromethyl)phenyl]ethan-1-ol

Formula: C₁₀H₈F₆O

Purezza: ≥95%

Colore e forma: white crystalline solid

Peso molecolare: 258.16g/mol

Ref: 54-PC0580

Fosaprepitant Impurity 25

CAS: 127852-28-2

Formula: C₁₀H₈F₆O

Peso molecolare: 258.16

Ref: 4Z-F-3633

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethan-1-ol

CAS: 127852-28-2

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethan-1-ol is a triazolinone that has been shown to be an efficient contactor for the removal of organic pollutants from water. It is activated by potassium t-butoxide and immobilized on silicone gels. This compound is also active against a broad range of bacteria and fungi.

Formula: C₁₀H₈F₆O

Purezza: Min. 98%

Colore e forma: White Powder

Peso molecolare: 258.16 g/mol

Ref: 3D-FB43523

(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethanol

CAS: 127852-28-2

Formula: C₁₀H₈F₆O

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 258.163

Ref: 10-F040986

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol

Prodotto controllato

CAS: 127852-28-2

Applications (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is an intermediate in the synthesis of Aprepitant (A729800), a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.
References Vankawala, P.J., et. al.: Synthetic Comm., 37, 3439 (2007); Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998); Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001); Van Belle, S., et al.: Cancer, 94, 3032 (2002); Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (2006)

Formula: C₁₀H₈F₆O

Colore e forma: Neat

Peso molecolare: 258.16

Ref: TR-B416125

Aprepitant Impurity 15

CAS: 127852-28-2

Formula: C₁₀H₈F₆O

Peso molecolare: 258.16

Ref: ST-EA-CP-A109041