CAS 128270-60-0

Bivalirudina

Descrizione:

Bivalirudina è un peptide sintetico che funge da inibitore diretto della trombina, utilizzato principalmente come anticoagulante in contesti clinici, in particolare durante le interventi coronarici percutanei. La sua struttura è composta da 20 aminoacidi ed è derivata dal peptide di irudina trovato nelle sanguisughe. Bivalirudina mostra un'alta affinità per la trombina, prevenendo efficacemente la conversione del fibrinogeno in fibrina, che è cruciale nel processo di coagulazione. La sostanza viene somministrata tramite iniezione endovenosa e ha una emivita relativamente breve, richiedendo un attento monitoraggio dei livelli di anticoagulazione durante il trattamento. Bivalirudina è caratterizzato dalla sua stabilità nel flusso sanguigno e dalla sua capacità di fornire anticoagulazione rapida con un profilo farmacocinetico prevedibile. È spesso preferito rispetto agli anticoagulanti tradizionali a causa del suo minor rischio di indurre trombocitopenia e della sua facilità d'uso in pazienti con funzione renale variabile. In generale, Bivalirudina rappresenta un significativo progresso nella terapia anticoagulante, in particolare nella gestione della sindrome coronarica acuta.

Formula: C₉₈H₁₃₈N₂₄O₃₃

InChI: InChI=1/C98H138N24O33/c1-5-52(4)82(96(153)122-39-15-23-70(122)92(149)114-60(30-34-79(134)135)85(142)111-59(29-33-78(132)133)86(143)116-64(43-55-24-26-56(123)27-25-55)89(146)118-67(97(154)155)40-51(2)3)119-87(144)61(31-35-80(136)137)112-84(141)58(28-32-77(130)131)113-88(145)63(42-54-18-10-7-11-19-54)117-90(147)66(45-81(138)139)110-76(129)50-107-83(140)65(44-71(100)124)109-75(128)49-106-73(126)47-104-72(125)46-105-74(127)48-108-91(148)68-21-13-38-121(68)95(152)62(20-12-36-103-98(101)102)115-93(150)69-22-14-37-120(69)94(151)57(99)41-53-16-8-6-9-17-53/h6-11,16-19,24-27,51-52,57-70,82,123H,5,12-15,20-23,28-50,99H2,1-4H3,(H2,100,124)(H,104,125)(H,105,127)(H,106,126)(H,107,140)(H,108,148)(H,109,128)(H,110,129)(H,111,142)(H,112,141)(H,113,145)(H,114,149)(H,115,150)(H,116,143)(H,117,147)(H,118,146)(H,119,144)(H,130,131)(H,132,133)(H,134,135)(H,136,137)(H,138,139)(H,154,155)(H4,101,102,103)/t52-,57+,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,82-/m0/s1

Sinonimi:

• L-leucine, D-phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-alpha-aspartyl-L-phenylalanyl-L-alpha-glutamyl-L-alpha-glutamyl-L-isoleucyl-L-prolyl-L-alpha-glutamyl-L-alpha-glutamyl-L-tyrosyl-
• D-phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-alpha-aspartyl-L-phenylalanyl-L-alpha-glutamyl-L-alpha-glutamyl-L-isoleucyl-L-prolyl-L-alpha-glutamyl-L-alpha-glutamyl-L-tyrosyl-L-leucine
• Bivalirudin,TFA
• Bivalirudin Trifluoroacetate

Bivalirudin

CAS: 128270-60-0

Bivalirudin is a highly specific and reversible direct thrombin inhibitor.

Formula: C₉₈H₁₃₈N₂₄O₃₃

Purezza: 98.9%

Colore e forma: White

Peso molecolare: 2180.32

Ref: 01-4049766

Bivalirudin

CAS: 128270-60-0

Cardiovascular drugs, not elsewhere specified or included

Formula: C₉₈H₁₃₈N₂₄O₃₃

Colore e forma: White Off-White Powder

Peso molecolare: 2178.98581

Ref: 45-1076013

L-Leucine, D-phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-α-aspartyl-L-phenylalanyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-prolyl-L-α-glutamyl-L-α-glutamyl-L-tyrosyl-

CAS: 128270-60-0

Formula: C₉₈H₁₃₈N₂₄O₃₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 2180.2853

Ref: IN-DA000XXZ

Bivalirudin

CAS: 128270-60-0

Formula: C₉₈H₁₃₈N₂₄O₃₃

Peso molecolare: 2180.29

Ref: 7W-GP4765

Bivalirudin

CAS: 128270-60-0

Formula: C₉₈H₁₃₈N₂₄O₃₃

Colore e forma: White To Off-White Solid

Peso molecolare: 2180.32

Ref: 4Z-PB-122001

Bivalirudin Trifluoroacetate

CAS: 128270-60-0

Formula: C₉₈H₁₃₈N₂₄O₃₃

Purezza: 95%~99%

Colore e forma: White to Off-white Powder

Peso molecolare: 2180.29

Ref: BP-BPPG010

Bivalirudin

CAS: 128270-60-0

Bivalirudin

Colore e forma: Powder

Peso molecolare: 2,180.29g/mol

Ref: 54-BITP1474

Bivalirudin

CAS: 128270-60-0

Bivalirudin (BG-8967) is a reversible inhibitor of α- and ζ-thrombin (Kis = 2.56 and 1.84 nM, respectively), enzymes that exhibit high fibrinogen-clotting

Formula: C₉₈H₁₃₈N₂₄O₃₃

Purezza: 98.8% - >99.99%

Colore e forma: White To Off-White Powder

Peso molecolare: 2180.29

Ref: TM-T5519

Bivalirudin

CAS: 128270-60-0

Bivalirudin is a synthetic cyclic peptide that binds to the ATP-binding cassette transporter and inhibits the activity of the proteolytic enzyme, angiotensin-converting enzyme (ACE). ACE inhibition prevents the conversion of angiotensin I to angiotensin II. Bivalirudin has been shown to be effective in reducing mortality in patients with acute coronary syndrome or undergoing percutaneous coronary intervention. It has also been shown to have pharmacokinetic properties that are similar to those of heparin. The drug has a low dose and is not associated with an increased risk of bleeding. Bivalirudin is an inhibitor and can cause drug interactions when combined with other drugs that are inhibitors or substrates for this type of transporter.

Formula: C₉₈H₁₃₈N₂₄O₃₃

Purezza: Min. 95%

Peso molecolare: 2,180.33 g/mol

Ref: 3D-BIV-3767-PI

Bivalirudin

CAS: 128270-60-0

Selectively inhibits α- and ζ-thrombins and elicits procoagulant effects. Reduces platelet deposition in a rat carotid endarterectomy model. Has therapeutic potential as an anti-thrombotic agent in patients with heparin-associated thrombosis.

Formula: C₉₈H₁₃₈N₂₄O₃₃

Purezza: Min. 95%

Colore e forma: White Solid

Peso molecolare: 2178.98581

Ref: 3D-FB29604

Bivalirudin 1-11 Fragment Trifluoroacetic Acid Salt

Prodotto controllato

CAS: 128270-60-0

Applications Bivalirudin 1-11 Fragment is an impurity of Bivalirudin, a direct thrombin inhibitor acting as an anticoagulant through inhibition of the enzyme thrombin.
References Bertrand, O. et al.: Am. J. Cardio., 110, 599 (2012); Patti, G. et al.: Am. J. Cardio., 110, 478 (2012)

Formula: C₄₃H₆₃N₁₅O₁₅·(C₂HF₃O₂)x

Colore e forma: Neat

Peso molecolare: 1030.0511402

Ref: TR-B591640