CAS 128545-09-5

N-[(9H-Fluoren-9-ilmetossi)carbonil]-3-(trifenilmetil)-L-istidina

Descrizione:

N-[(9H-Fluoren-9-ilmetossi)carbonil]-3-(trifenilmetil)-L-istidina, comunemente noto come Fmoc-His(Trt)-OH, è una forma protetta dell'aminoacido istidina utilizzata principalmente nella sintesi di peptidi. Questo composto presenta un gruppo protettivo fluorenilmetossicarbonile (Fmoc), ampiamente utilizzato per la protezione temporanea dei gruppi amminici durante la sintesi di peptidi. Il gruppo triphenylmethyl (Trt) fornisce ulteriore protezione per la catena laterale dell'istidina, migliorando la stabilità e prevenendo reazioni indesiderate. La presenza di questi gruppi protettivi consente reazioni di deprotezione e accoppiamento selettive, facilitando l'assemblaggio di peptidi complessi. Fmoc-His(Trt)-OH è tipicamente un solido bianco a bianco sporco ed è solubile in solventi organici come dimetilformammide (DMF) e dimetilsolfossido (DMSO), ma meno solubile in acqua. La sua stabilità in condizioni standard di accoppiamento di peptidi lo rende un intermedio prezioso nel campo della chimica organica e medicinale, in particolare nello sviluppo di terapie basate su peptidi.

Formula: C₄₀H₃₃N₃O₄

InChI: InChI=1/C40H33N3O4/c44-38(45)37(42-39(46)47-26-36-34-22-12-10-20-32(34)33-21-11-13-23-35(33)36)24-31-25-41-27-43(31)40(28-14-4-1-5-15-28,29-16-6-2-7-17-29)30-18-8-3-9-19-30/h1-23,25,27,36-37H,24,26H2,(H,42,46)(H,44,45)/p-1/t37-/m0/s1

InChI key: InChIKey=LCDUPKDPUSBXAY-QNGWXLTQSA-N

SMILES: C(N1C(C[C@H](NC(OCC2C=3C(C=4C2=CC=CC4)=CC=CC3)=O)C(O)=O)=CN=C1)(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7

Sinonimi:

• (2S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-(1-trityl-1H-imidazol-5-yl)propanoate
• <span class="text-smallcaps">L</span>-Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-(triphenylmethyl)-
• Fmoc-His(Trt)-OH
• Fmoc-L-His(Trt)-OH
• N(alpha)-fmoc-N(im)-trityl-L-histidine
• N-FMOC-3-(triphenylmethyl)-L-histidine
• N-Fmoc-N'-trityl-L-histidine
• N-[(9H-Fluoren-6-ylmethoxy)carbonyl]-3-(triphenylmethyl)-L-histidine
• N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(triphenylmethyl)-<span class="text-smallcaps">L</span>-histidine
• N-[(9H-fluoren-9-ylmethoxy)carbonyl]-1-tritylhistidine
• N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-trityl-L-histidine
• N-alpha-(9-fluorenylmethyloxycarbonyl)-N-im-trityl-L-histidine
• N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(triphenylmethyl)-L-histidine
• L-Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-(triphenylmethyl)-
• N-ALPHA-FMOC--TRITYL-L-HISTIDINE
• FMOC-L-HIS(1-TRT)-OH
• N-[(9H-Fluoroen-6-ylmethoxy)carbonyl]-3-(triphenylmethyl)-L-histidine
• N-FMOC-3-(triphenylmethyl)-L-histidine USP/EP/BP
• Nalpha-fluorenylmethoxycarbonyl-im-trityl-L-histidine
• (S)-2-((((9H-Fluoren-3-yl)methoxy)carbonyl)amino)-3-(1-trityl-1H-imidazol-5-yl)propanoic acid
• NALPHA-9-Fluorenylmethoxycarbonyl-NPI-trityl-L-histidine
• na-fmoc-im-trityl-L-histidine

L-Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-(triphenylmethyl)-

CAS: 128545-09-5

Formula: C₄₀H₃₃N₃O₄

Peso molecolare: 619.7077

Ref: IN-DA000Y76

Fmoc-His(Trt)-OH

CAS: 128545-09-5

Fmoc-His(Trt)-OH is a synthetic antimicrobial peptide that belongs to the class of acetylcholine. The peptide was found to inhibit the growth of a number of bacterial genera, including Pseudomonas, Acinetobacter and Burkholderia. The sequence of Fmoc-His(Trt)-OH is acetylated at the N-terminus and amidated at the C-terminus. This peptide has been found to have a broad spectrum of activity against drug resistant bacteria. It has also been shown to be active against mammalian cells in addition to bacterial cells, suggesting it may have therapeutic potential for humans as well as animals.

Formula: C₄₀H₃₃N₃O₄

Purezza: Min. 98.0 Area-%

Peso molecolare: 619.73 g/mol

Ref: 3D-FLH-1740-PI