CAS 129-49-7

Maleato di metisergide

Descrizione:

Maleato di metisergide è un composto sintetico conosciuto principalmente per il suo utilizzo nel trattamento dell'emicrania e delle cefalee a grappolo. È un derivato dell'acido lisergico e agisce come antagonista del recettore della serotonina, in particolare nei siti recettoriali 5-HT2. La sostanza appare come una polvere cristallina bianca o bianco sporco ed è tipicamente somministrata sotto forma di compresse. Maleato di metisergide è caratterizzato dalla sua relativamente bassa solubilità in acqua, il che può influenzare la sua biodisponibilità e farmacocinetica. Ha una emivita moderata, consentendo una somministrazione una o due volte al giorno in contesti clinici. Tuttavia, l'uso prolungato può portare a effetti collaterali, tra cui fibrosi retroperitoneale e ipertensione polmonare, richiedendo un attento monitoraggio dei pazienti. A causa di questi potenziali effetti avversi, il suo utilizzo è diventato meno comune e viene spesso considerato quando altri trattamenti hanno fallito. Maleato di metisergide è classificato nella categoria degli alcaloidi dell'ergot, noti per le loro proprietà vasocostrittrici.

Formula: C₂₁H₂₇N₃O₂·C₄H₄O₄

InChI: InChI=1/C21H27N3O2.C4H4O4/c1-4-15(12-25)22-21(26)14-8-17-16-6-5-7-18-20(16)13(10-23(18)2)9-19(17)24(3)11-14;5-3(6)1-2-4(7)8/h5-8,10,14-15,19,25H,4,9,11-12H2,1-3H3,(H,22,26);1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,15+,19-;/m1./s1

SMILES: CN1C2=C3C(C=4[C@@](CC3=C1)(N(C)C[C@H](C(N[C@@H](CC)CO)=O)C4)[H])=CC=C2.C(=C\C(O)=O)\C(O)=O

Sinonimi:

• (+)-N-[(1-Hydroxymethyl)propyl]-1-methyl-<span class="text-smallcaps">D</span>-lysergamide bimaleate
• (8beta)-N-[(1S)-1-(hydroxymethyl)propyl]-1,6-dimethyl-9,10-didehydroergoline-8-carboxamide (2Z)-but-2-enedioate (salt)
• (8beta)-N-[(2S)-1-hydroxybutan-2-yl]-1,6-dimethyl-9,10-didehydroergoline-8-carboxamide
• 1-Methyl-<span class="text-smallcaps">D</span>-lysergic acid butanolamide bimaleate
• Deseril-retard
• Desernil
• Desernil bimaleate
• Ergoline-8-carboxamide, 9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-1,6-dimethyl-, (8β)-, (2Z)-2-butenedioate (1:1)
• Ergoline-8-carboxamide, 9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-1,6-dimethyl-, (8β)-, (2Z)-2-butenedioate (1:1) (salt)
• Ergoline-8-carboxamide, 9,10-didehydro-N-[1-(hydroxymethyl)propyl]-1,6-dimethyl-, [8β(S)]-, (Z)-2-butenedioate (1:1) (salt)
• Ergoline-8β-carboxamide, 9,10-didehydro-N-[1-(hydroxymethyl)propyl]-1,6-dimethyl-, maleate (1:1) (salt)
• Lysergamide, N-[1-(hydroxymethyl)propyl]-1-methyl-, maleate
• Methysergide Hydrogen Maleate
• Methysergide bimaleate
• NSC 186061

Methysergide Maleate

CAS: 129-49-7

Alkaloids of rye ergot and their derivatives; salts the

Formula: C₂₁H₂₇N₃O₂·C₄H₄O₄

Colore e forma: Powder

Peso molecolare: 469.22129

Ref: 45-1440003

Methysergide maleate salt

CAS: 129-49-7

Formula: C₂₅H₃₁N₃O₆

Purezza: ≥ 99.0% (anhydrous)

Colore e forma: White to off-white crystalline powder

Peso molecolare: 469.53

Ref: 7W-GP2886

Methysergide Maleate

Prodotto controllato

CAS: 129-49-7

Stability Hygroscopic
Applications Methysergide Maleate acts as a serotonin antagonist with potential application antidepression medication. It is a 5-HT antagonist.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Masalov, I. et al.: J. Evol. Biochem. Phys., 48, 523 (2012); Fletcher, P. et al.: Psychopharm., 96, 236 (1988);

Formula: C₂₁H₂₇N₃O₂·C₄H₄O₄

Colore e forma: Neat

Peso molecolare: 469.53

Ref: TR-M329350

Methysergide maleate monohydrate

Prodotto controllato

CAS: 129-49-7

Methylergide maleate monohydrate is a high-quality reagent that is useful as an intermediate for the synthesis of complex compounds. It is also a fine chemical that can be used in research and development. Methylergide maleate monohydrate has CAS No. 129-49-7, and it can be used to produce speciality chemicals or reaction components. It has a wide range of applications, such as being a versatile building block in organic synthesis and being a reaction component for the production of pharmaceuticals or agrochemicals.

Formula: C₂₅H₃₃N₃O₇

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 487.55 g/mol

Ref: 3D-FM39378

Methysergide maleate

Prodotto controllato

CAS: 129-49-7

Methysergide is a drug that has been used in the treatment of chronic schizophrenia and other neurological disorders. It is an antagonist of glutamate, which inhibits the release of 5-HT (serotonin) and thereby reduces the concentration of this neurotransmitter in the brain. Methysergide has also been shown to inhibit the production of carcinoid syndrome and gamma-aminobutyric acid (GABA). Methysergide is related to estradiol benzoate, which is used to treat autoimmune diseases such as systemic lupus erythematosus (SLE). Symptoms may include fever, joint pain, photosensitivity, skin rash, muscle pain, and weight loss. The pharmacological treatment for these symptoms includes methotrexate or corticosteroids.

Formula: C₂₁H₂₇N₃O₂·C₄H₄O₄

Purezza: Min. 95%

Peso molecolare: 469.53 g/mol

Ref: 3D-FM75152

Methysergide maleate

CAS: 129-49-7

Methysergide prevents migraines/cluster headaches; treats serotonin syndrome, carcinoid-induced diarrhea; risk of fibrosis limits use.

Formula: C₂₅H₃₁N₃O₆

Purezza: 98%

Colore e forma: White To Off-White

Peso molecolare: 469.54

Ref: TM-T21423

Methysergide maleate

CAS: 129-49-7

Methysergide maleate

Formula: C₂₁H₂₇N₃O₂

Purezza: 72.6%

Colore e forma: Off White Solid

Peso molecolare: 353.21033

Ref: 47-409