CAS 129203-60-7

iberiotossina da buthus tamulus

Descrizione:

L'iberiotossina, derivata del veleno dello scorpione rosso indiano (Buthus tamulus), è una potente neurotossina nota per la sua inibizione selettiva di alcuni canali del potassio, in particolare i canali del potassio voltaggio-dipendenti (Kv) nei tessuti eccitabili. Questa caratteristica la rende uno strumento prezioso nella neurofarmacologia per studiare la funzione dei canali ionici e i ruoli fisiologici dei canali del potassio in vari processi cellulari. L'iberiotossina mostra un'alta affinità per il canale Kv1.3, implicato nelle risposte immunitarie e nell'eccitabilità neuronale. La struttura della tossina è caratterizzata da una catena polipeptidica che si ripiega in una specifica conformazione tridimensionale, permettendole di interagire efficacemente con i suoi canali target. Il suo meccanismo d'azione implica il legame al canale e la prevenzione del flusso di ioni di potassio, il che può portare a una depolarizzazione prolungata di neuroni e cellule muscolari. A causa dei suoi potenti effetti, l'iberiotossina è anche di interesse nella ricerca relativa al dolore, all'infiammazione e alle potenziali applicazioni terapeutiche, sebbene il suo uso sia principalmente confinato a contesti di laboratorio a causa della sua tossicità.

Formula: C₁₇₉H₂₇₄N₅₀O₅₅S₇

InChI: InChI=1/C179H274N50O55S7/c1-87(2)65-111-155(261)208-112(66-93-33-15-13-16-34-93)146(252)195-77-133(239)225-139(88(3)4)172(278)213-117(71-136(244)245)158(264)199-100(44-31-62-190-178(186)187)144(250)193-75-131(237)198-102(40-22-27-58-181)148(254)219-124(167(273)205-109(56-64-285-12)145(251)194-76-132(238)197-101(39-21-26-57-180)147(253)200-105(43-25-30-61-184)151(257)220-123-81-286-288-83-125(221-152(258)106(203-166(123)272)45-32-63-191-179(188)189)169(275)210-113(68-95-46-48-97(234)49-47-95)156(262)206-110(177(283)284)50-53-129(185)235)82-287-291-86-128(168(274)202-104(42-24-29-60-183)150(256)212-116(70-135(242)243)159(265)207-111)224-175(281)142(91(9)10)228-164(270)121(79-231)216-157(263)115(69-96-74-192-99-38-20-19-37-98(96)99)211-170(276)126-84-289-290-85-127(171(277)217-122(80-232)165(271)227-141(90(7)8)174(280)218-120(78-230)163(269)201-103(41-23-28-59-182)149(255)204-108(154(260)222-126)52-55-134(240)241)223-160(266)118(72-137(246)247)214-173(279)140(89(5)6)226-162(268)119(73-138(248)249)215-176(282)143(92(11)233)229-161(267)114(67-94-35-17-14-18-36-94)209-153(259)107-51-54-130(236)196-107/h13-20,33-38,46-49,74,87-92,100-128,139-143,192,230-234H,21-32,39-45,50-73,75-86,180-184H2,1-12H3,(H2,185,235)(H,193,250)(H,194,251)(H,195,252)(H,196,236)(H,197,238)(H,198,237)(H,199,264)(H,200,253)(H,201,269)(H,202,274)(H,203,272)(H,204,255)(H,205,273)(H,206,262)(H,207,265)(H,208,261)(H,209,259)(H,210,275)(H,211,276)(H,212,256)(H,213,278)(H,214,279)(H,215,282)(H,216,263)(H,217,277)(H,218,280)(H,219,254)(H,220,257)(H,221,258)(H,222,260)(H,223,266)(H,224,281)(H,225,239)(H,226,268)(H,227,271)(H,228,270)(H,229,267)(H,240,241)(H,242,243)(H,244,245)(H,246,247)(H,248,249)(H,283,284)(H4,186,187,190)(H4,188,189,191)

SMILES: CC(C)CC1C(=NC(Cc2ccccc2)C(=NCC(=NC(C(C)C)C(=NC(CC(=O)O)C(=NC(CCCNC(=N)N)C(=NCC(=NC(CCCCN)C(=NC(CSSCC(C(=NC(CCCCN)C(=NC(CC(=O)O)C(=N1)O)O)O)N=C(C(C(C)C)N=C(C(CO)N=C(C(Cc1c[nH]c2ccccc12)N=C(C1CSSCC(C(=NC(CO)C(=NC(C(C)C)C(=NC(CO)C(=NC(CCCCN)C(=NC(CCC(=O)O)C(=N1)O)O)O)O)O)O)N=C(C(CC(=O)O)N=C(C(C(C)C)N=C(C(CC(=O)O)N=C(C(C(C)O)N=C(C(Cc1ccccc1)N=C(C1CCC(=N1)O)O)O)O)O)O)O)O)O)O)O)C(=NC(CCSC)C(=NCC(=NC(CCCCN)C(=NC(CCCCN)C(=NC1CSSCC(C(=NC(Cc2ccc(cc2)O)C(=NC(CCC(=N)O)C(=O)O)O)O)N=C(C(CCCNC(=N)N)N=C1O)O)O)O)O)O)O)O)O)O)O)O)O)O)O

Sinonimi:

• Iberiotoxin, Buthus tamulus
• Pyr-Phe-Thr-Asp-Val-Asp-Cys-Ser-Val-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-Gln-OH (Disulfide bonds between Cys7 and Cys28/Cys13 and Cys33/ Cys17 and Cys35)
• Iberiotoxin

Iberiotoxin

CAS: 129203-60-7

Iberiotoxin (IbTx), from the venom of the scorpion Buthus tamulus, shows 68% sequence homology with charybdotoxin, another scorpion-derived peptidyl toxin. Although these two toxins both inhibit the high conductance Ca²⁺ activated K⁺ channel, they appear to bind at different sites on the channel and modulate channel activity by different mechanisms. Thus, iberiotoxin can be used to selectively study the function of the high conductance Ca²⁺ activated K⁺ channel.

Formula: C₁₇₉H₂₇₄N₅₀O₅₅S₇

Purezza: > 95%

Colore e forma: Whitish Powder

Peso molecolare: 4230.91

Ref: 01-4030755

2-(2-{[10-(2-{2-[2-(2-{[7,34-bis(4-aminobutyl)-25-benzyl-13-(3-carbamimidamidopropyl)-16,31-bis(carboxymethyl)-28-(2-methylpropyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-19-(propan-2-yl)-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriaco

CAS: 129203-60-7

Formula: C₁₇₉H₂₇₄N₅₀O₅₅S₇

Purezza: ≥95%

Peso molecolare: 4230.8479

Ref: IN-DA000YY4

Iberiotoxin

CAS: 129203-60-7

Selective blocker of the big conductance Ca2+-activated K+ channel.

Formula: C₁₇₉H₂₇₄N₅₀O₅₅S₇

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 4230

Ref: TM-TP2014

Iberiotoxin

CAS: 129203-60-7

Iberiotoxin a synthetic scorpion toxin sourced from the Buthus tamulus scorpion, has disufide bonds formed between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35. This prodict can be used as a Ca2+-Activated K+ Channel Blocker (Maxi-K+ Channel Blocker). This peptide can be used in pharmacological studies to investigate the effects of Iberiotoxin on various ion channels and receptors.

Formula: C₁₇₉H₂₇₄N₅₀O₅₅S₇

Purezza: Min. 95%

Peso molecolare: 4,230.8 g/mol

Ref: 3D-PIB-3813-PI

Iberiotoxin

CAS: 129203-60-7

Iberiotoxin is a neurotoxin that is synthesized by the bacterium Clostridium botulinum. It inhibits the activity of a number of enzymes, including protein kinase C and cyclase, but has no effect on phosphatases. Iberiotoxin has been shown to be effective against models systems of bowel disease, such as colonic inflammation and ulceration. Iberiotoxin binds to specific neuronal receptors in the central nervous system, leading to inhibition of intracellular calcium levels, which may play an important role in the mechanisms of action for this toxin.

Formula: C₁₇₉H₂₇₄N₅₀O₅₅S₇

Purezza: Min. 95%

Peso molecolare: 4,230.86 g/mol

Ref: 3D-FI110468

Iberiotoxin

CAS: 129203-60-7

Iberiotoxin a synthetic scorpion toxin sourced from the Buthus tamulus scorpion, has disufide bonds formed between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35. This prodict can be used as a Ca2+-Activated K+ Channel Blocker (Maxi-K+ Channel Blocker). This peptide can be used in pharmacological studies to investigate the effects of Iveriotoxin on various ion channels and receptors. This product is available as a 0.1mg vial.

Formula: C₁₇₉H₂₇₄N₅₀O₅₅S₇

Purezza: Min. 95%

Peso molecolare: 4,230.8 g/mol

Ref: 3D-PIB-4235-S