CAS 130-16-5

5-Cloro-8-idrossichinolina

Descrizione:

5-Cloro-8-idrossichinolina è un composto organico caratterizzato dalla sua struttura di chinolina, che consiste in un anello di benzene e un anello di piridina fusi. La presenza di un atomo di cloro nella posizione 5 e di un gruppo idrossile nella posizione 8 contribuisce alle sue uniche proprietà chimiche. Questo composto appare come un solido cristallino di colore giallo-marrone ed è noto per le sue applicazioni in vari campi, tra cui farmaceutici e chimica analitica. Mostra attività antimicrobiche e antifungine, rendendolo utile nella chimica medicinale. Inoltre, 5-Cloro-8-idrossichinolina può agire come agente chelante, formando complessi con ioni metallici, il che è prezioso nelle tecniche analitiche. Il composto è moderatamente solubile in solventi organici e ha una solubilità limitata in acqua, il che influisce sul suo comportamento in diversi ambienti chimici. Devono essere prese in considerazione le considerazioni di sicurezza, poiché può comportare rischi per la salute in caso di esposizione. In generale, 5-Cloro-8-idrossichinolina è un composto versatile con una rilevanza significativa sia nella ricerca che nelle applicazioni industriali.

Formula: C₉H₆ClNO

InChI: InChI=1S/C9H6ClNO/c10-7-3-4-8(12)9-6(7)2-1-5-11-9/h1-5,12H

InChI key: InChIKey=CTQMJYWDVABFRZ-UHFFFAOYSA-N

SMILES: ClC=1C2=C(C(O)=CC1)N=CC=C2

Sinonimi:

• 5-Chloro-8-oxyquinoline
• 5-Chloro-8-quinolinol
• 5-Chloro-quinoline-8-ol
• 5-Chlorooxine
• 5-Chloroquinolin-8-Ol
• 8-Hydroxy-5-chloroquinoline
• 8-Quinolinol, 5-chloro-
• Cloxiquine
• Cloxyquin
• Dermofongin
• Dermofungin
• NSC 35083
• NSC 53182
• NSC 74943

5-Chloro-8-hydroxyquinoline

CAS: 130-16-5

Formula: C₉H₆ClNO

Purezza: >98.0%(GC)(T)

Colore e forma: White to Light yellow to Green powder to crystal

Peso molecolare: 179.60

Ref: 3B-C0645

Cloxiquine

CAS: 130-16-5

Colore e forma: Neat

Ref: 61-FOR0391.00

Clioquinol Related Compound A (5-Chloroquinolin-8-ol)

CAS: 130-16-5

Compounds containing a quinoline or isoquinoline ring-system, whether or not hydrogenated, not further fused, excluding drugs and pesticides

Formula: C₉H₆ClNO

Colore e forma: Off-White Powder

Peso molecolare: 179.01379

Ref: 45-1138212

8-​Quinolinol, 5-​chloro-

CAS: 130-16-5

Formula: C₉H₆ClNO

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 179.6030

Ref: IN-DA000TUR

Cloxiquine

CAS: 130-16-5

Cloxiquine (Dermofongin) is a monohalogenated 8-hydroxyquinoline with activity against bacteria, fungi, and protozoa.

Formula: C₉H₆ClNO

Purezza: 99.82% - 99.87%

Colore e forma: Light Yellow Crystals

Peso molecolare: 179.6

Ref: TM-T0509

Cloxiquine

CAS: 130-16-5

Cloxiquine

Purezza: ≥98%

Peso molecolare: 179.6g/mol

Ref: 54-BUP19781

5-Chloro-8-hydroxyquinoline

CAS: 130-16-5

Formula: C₉H₆ClNO

Purezza: ≥ 98.0%

Colore e forma: Off-white to light-yellow or light-green powder

Peso molecolare: 179.61

Ref: 7W-GK7391

5-Chloro-8-hydroxyquinoline

CAS: 130-16-5

5-Chloro-8-hydroxyquinoline

Formula: C₉H₆ClNO

Purezza: 98%

Colore e forma: beige powder

Peso molecolare: 179.60g/mol

Ref: 54-OR1049

Clioquinol EP Impurity A (Clioquinol USP Related Compound A, Cloxyquin)

CAS: 130-16-5

Formula: C₉H₆ClNO

Colore e forma: White To Off-White Solid

Peso molecolare: 179.61

Ref: 4Z-C-801

5-Chloro-8-hydroxyquinoline

CAS: 130-16-5

Formula: C₉H₆ClNO

Purezza: 98%

Colore e forma: Crystalline

Peso molecolare: 179.6

Ref: 10-F119500

Cloxiquine

CAS: 130-16-5

Formula: C₉H₆ClNO

Colore e forma: Neat

Peso molecolare: 179.60

Ref: 04-C11692130

Cloxiquine

Prodotto controllato

CAS: 130-16-5

Formula: C₉H₆ClNO

Colore e forma: Neat

Peso molecolare: 179.60

Ref: 86-MM0391.00

5-Chloroquinolin-8-ol

Prodotto controllato

CAS: 130-16-5

Formula: C₉H₆ClNO

Colore e forma: Neat

Peso molecolare: 179.60

Ref: 86-MM0312.01

Dermofungin

Prodotto controllato

CAS: 130-16-5

Applications Dermofungin, is an impurity of Cioquinol, which is an antifungal and antiprotozoal drug.
References Hongchao, J., et al.: Cancer Lett., 312, 11 (2011); LeVine, H., et al.: Neuroscience Lett., 465, 99 (2009);

Formula: C₉H₆ClNO

Colore e forma: Neat

Peso molecolare: 179.60

Ref: TR-D281930

Clioquinol EP Impurity A

CAS: 130-16-5

Formula: C₉H₆ClNO

Peso molecolare: 179.60

Ref: ST-EA-CP-C41001

5-Chloro-8-hydroxyquinoline

CAS: 130-16-5

5-Chloro-8-hydroxyquinoline (5-CQ) is a quinoline derivative that has been used as an anticancer agent. It binds to DNA and inhibits the synthesis of RNA and proteins, leading to cell death. 5-CQ has been shown to be cytotoxic against skin cells in vitro by inhibiting mitochondrial oxidative phosphorylation and decreasing the mitochondrial membrane potential. This compound also has genotoxic effects on cultured choroidal neovascularization cells through the inhibition of DNA synthesis.
5-CQ binds to DNA via hydrogen bonds with nitrogen atoms in the purine ring of nucleobases. The overall geometry is that of a distorted octahedron with two faces, each containing six nitrogens in square planar coordination geometry. The binding constants are low for purines but high for pyrimidines, which is why 5-CQ preferentially targets purine rich regions of the genome.

Formula: C₉H₆ClNO

Purezza: Min. 95%

Colore e forma: Green To Grey Solid

Peso molecolare: 179.6 g/mol

Ref: 3D-FC40563

5-Chloro-8-hydroxyquinoline, 95%

CAS: 130-16-5

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Formula: C₉H₆ClNO

Purezza: 95%

Colore e forma: White to cream to pale green to pale brown to grey, Powder

Peso molecolare: 179.60

Ref: 02-B22856