CAS 131602-53-4

frammento di proteina beta-amiloide 25-35

Descrizione:

Il frammento della proteina beta-amiloide 25-35 (spesso chiamato Aβ25-35) è un peptide derivato dalla proteina precursore dell'amiloide (APP) ed è significativo nello studio della malattia di Alzheimer. Questo frammento è composto da 11 aminoacidi ed è noto per il suo ruolo nella formazione delle placche amiloidi, che sono caratteristiche della patologia di Alzheimer. Aβ25-35 è particolarmente notevole per le sue proprietà neurotossiche, poiché può indurre stress ossidativo e promuovere la morte cellulare neuronale. Il peptide è spesso utilizzato nella ricerca per modellare gli effetti della beta-amiloide nei processi neurodegenerativi. La sua struttura consente l'aggregazione, portando alla formazione di fibrille che possono interrompere la funzione cellulare. Inoltre, Aβ25-35 è stato implicato nella modulazione dell'attività sinaptica e può influenzare le funzioni cognitive. Comprendere le caratteristiche e il comportamento di questo frammento è cruciale per sviluppare strategie terapeutiche mirate a mitigare gli effetti della beta-amiloide nella malattia di Alzheimer e nei disturbi correlati.

Formula: C₄₅H₈₁N₁₃O₁₄S

InChI: InChI=1/C45H81N13O14S/c1-9-24(5)36(43(69)50-21-35(63)52-29(17-23(3)4)40(66)55-28(45(71)72)14-16-73-8)58-44(70)37(25(6)10-2)57-38(64)26(7)51-34(62)20-49-39(65)27(13-11-12-15-46)54-41(67)30(18-32(48)60)56-42(68)31(22-59)53-33(61)19-47/h23-31,36-37,59H,9-22,46-47H2,1-8H3,(H2,48,60)(H,49,65)(H,50,69)(H,51,62)(H,52,63)(H,53,61)(H,54,67)(H,55,66)(H,56,68)(H,57,64)(H,58,70)(H,71,72)/t24-,25-,26-,27-,28-,29-,30-,31-,36-,37-/m0/s1

SMILES: CC[C@H](C)[C@@H](C(=NCC(=N[C@@H](CC(C)C)C(=N[C@@H](CCSC)C(=O)O)O)O)O)N=C([C@H]([C@@H](C)CC)N=C([C@H](C)N=C(CN=C([C@H](CCCCN)N=C([C@H](CC(=N)O)N=C([C@H](CO)N=C(CN)O)O)O)O)O)O)O

Sinonimi:

• Amyloid Beta-Protein (Human, 25-35) Trifluoroacetate
• Beta-Amyloid(25-35)
• Abeta 25-35

Amyloid β (25-35)

CAS: 131602-53-4

For cellular and molecular biology applications

Colore e forma: Powder, White to off-white

Ref: 02-J66808

Amyloid β-Protein (25-35)

CAS: 131602-53-4

The biologically active domain of the amyloid β-protein for neurotrophic and neurotoxic effects is located in the β (25-35) sequence GSNKGAIIGLM, which is homologous to a region in peptides of the tachykinin family.

Formula: C₄₅H₈₁N₁₃O₁₄S

Purezza: 97.0%

Colore e forma: White Powder

Peso molecolare: 1060.28

Ref: 01-4030205

β-Amyloid (25-35)

CAS: 131602-53-4

β-Amyloid (25-35) (Aβ25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide. Which has shown neurotoxic activities in cultured cells.

Formula: C₄₅H₈₁N₁₃O₁₄S

Purezza: 97.91%

Colore e forma: Solid

Peso molecolare: 1060.27

Ref: TM-T14284

β-Amyloid (25-35)

CAS: 131602-53-4

β-Amyloid (25-35)

Purezza: ≥95%

Peso molecolare: 1060.27g/mol

Ref: 54-BUP01506

Amyloid β Protein fragment 25-35

CAS: 131602-53-4

Amyloid β Protein fragment 25-35

Purezza: 97%

Peso molecolare: 1,060.27g/mol

Ref: 54-BIBA1010

Amyloid β-Protein (Human, 25-35)

CAS: 131602-53-4

Amyloid beta-Protein (Human, 25-35) is the shortest amyloid fragment that forms β-sheet fibrils, while retaining toxicity, and may also induce the aggregation of N-tau protein and N-tau peptide 1/2R. Consequently this peptide may play a role in the pathogenesis of Alzheimer's disease, a neurodegenerative disorder that affects memory and cognitive function.
This product is available as a trifluoroacetate salt and as a 0.5mg vial.

Formula: C₄₅H₈₁N₁₃O₁₄S

Purezza: Min. 95%

Peso molecolare: 1,060.3 g/mol

Ref: 3D-PAM-4309-V

Amyloid β-Protein (25-35) trifluoroacetate salt

CAS: 131602-53-4

Amyloid beta-protein (Aβ) is a protein that is a major component of amyloid plaques in the brains of people with Alzheimer's disease. Aβ-Protein (25-35) trifluoroacetate salt, also known as Aβ(25-35), is an amyloid beta protein fragment that has been shown to inhibit neuronal death and increase antioxidative properties in human serum. It has been shown to have anti-apoptotic effects by inhibiting the activation of caspases and the release of cytochrome C from mitochondria. This drug may have physiological effects on the central nervous system due to its ability to induce apoptosis through mitochondrial membrane depolarization and cytosolic calcium levels. It has been shown to be active against Chinese herb Pueraria lobata and cell lysis, as well as granule neurons in culture. It may also stimulate phosphorylation of p38mapk and induce logarithmic growth

Formula: C₄₅H₈₁N₁₃O₁₄S

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 1,060.27 g/mol

Ref: 3D-FA108377

AMYLOID β-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE

CAS: 131602-53-4

Formula: C₄₅H₈₁N₁₃O₁₄S

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 1060.268340000001

Ref: IN-DA009ATE