CAS 13268-67-2

ossido di senecionina N

Descrizione:

ossido di senecionina N è un alcaloide pirrolizidico, una classe di composti noti per le loro strutture complesse e potenziali attività biologiche. Questa sostanza è derivata dalla senecionina, che si trova in varie piante, in particolare in quelle della famiglia Asteraceae. ossido di senecionina N è caratterizzato dalla sua struttura eterociclica contenente azoto, che contribuisce alle sue proprietà farmacologiche. Di solito appare come un solido cristallino ed è solubile in solventi organici. Il composto ha attirato attenzione a causa della sua potenziale tossicità, in particolare in relazione ai danni al fegato e agli effetti cancerogeni associati a esposizione prolungata o ingestione. Il suo meccanismo d'azione spesso implica attivazione metabolica che porta alla formazione di intermedi reattivi. Come molti alcaloidi, ossido di senecionina N può mostrare una gamma di attività biologiche, inclusi effetti antimicrobici e citotossici, sebbene il suo profilo di sicurezza richieda cautela nel suo utilizzo. In generale, sebbene susciti interesse per la ricerca, le sue implicazioni tossicologiche sono significative e giustificano un'attenta manipolazione e studio.

Formula: C₁₈H₂₅NO₆

InChI: InChI=1/C18H25NO6/c1-4-12-9-11(2)18(3,22)17(21)24-10-13-5-7-19(23)8-6-14(15(13)19)25-16(12)20/h4-5,11,14-15,22H,6-10H2,1-3H3/b12-4+/t11-,14-,15-,18-,19?/m1/s1

InChI key: InChIKey=PLGBHVNNYDZWGZ-GPUZEBNTSA-N

SMILES: O=N12[C@]3([C@@](CC1)(OC(=O)/C(=C\C)/C[C@@H](C)[C@@](C)(O)C(=O)OCC3=CC2)[H])[H]

Sinonimi:

• (1,6)Dioxacyclododecino(2,3,4-gh)pyrrolizine-3,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-5,6-dimethyl-, 12-oxide, (3Z,5R,6R,14aR,14bR)-
• (3E,5R,6R,14aR,14bR)-3-ethylidene-6-hydroxy-5,6-dimethyl-3,4,5,6,9,11,13,14,14a,14b-decahydro[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione 12-oxide
• (5R,6R,14aR,14bR)-3-ethylidene-6-hydroxy-5,6-dimethyl-3,4,5,6,9,11,13,14,14a,14b-decahydro[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione 12-oxide
• 12-Hydroxysenecionan-11,16-dione 4-oxide
• Nsc 106677
• Senecionan-11,16-dione, 12-hydroxy-, 4-oxide
• Senecionine oxide
• [1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-5,6-dimethyl-, 12-oxide, (3Z,5R,6R,14aR,14bR)-
• [1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-5,6-dimethyl-, 12-oxide, (3Z,5R,6R,14aR,14bR)-[partial]-
• Senecionine N-oxide
• Senecionin-N-oxid

Senecionine N-oxide

CAS: 13268-67-2

Senecionine N-oxide: biosynthesized in Trichoderma lucidum roots, has antitumor properties, but can cause liver syndrome.

Formula: C₁₈H₂₅NO₆

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 351.39

Ref: TM-TN2203

Senecionine N-oxide

CAS: 13268-67-2

Formula: C₁₈H₂₅NO₆

Peso molecolare: 351.40

Ref: 7W-GY9519

Pyrrolizidine alkaloids Mixture 661 100 µg/mL in Methanol

Prodotto controllato

CAS: 101687-28-9, 10285-06-0, 10285-07-1, 127-30-0, 130-01-8, 13268-67-2, 15503-86-3, 2318-18-5, 303-33-3, 303-34-4, 38710-26-8, 41093-89-4, 480-54-6, 480-81-9, 520-68-3, 570-19-4, 6209-65-0, 65582-53-8, 72755-25-0, 95462-14-9, 95462-15-0

Colore e forma: Mixture

Ref: 04-A50000661ME

Senecionine-N-oxide 100 µg/mL in Water

Prodotto controllato

CAS: 13268-67-2

Formula: C₁₈H₂₅NO₆

Colore e forma: Single Solution

Peso molecolare: 351.39

Ref: 04-A16934010WA-100

Senecionine N-oxide

CAS: 13268-67-2

Formula: C₁₈H₂₅NO₆

Purezza: 95%~99%

Peso molecolare: 351.399

Ref: BP-BP4019

Senecionine N-Oxide-d3

CAS: 13268-67-2

Formula: C₁₈H₂₂D₃NO₆

Peso molecolare: 354.42

Ref: 4Z-S-110004

Senecionine N-Oxide

CAS: 13268-67-2

Formula: C₁₈H₂₅NO₆

Peso molecolare: 351.40

Ref: 4Z-S-110002

Senecionine n-oxide

CAS: 13268-67-2

Natural alkaloid

Formula: C₁₈H₂₅NO₆

Purezza: ≥ 95.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 351.4

Ref: 5G-82631

Senecionine N-Oxide-D3

Prodotto controllato

CAS: 13268-67-2

Stability Hygroscopic
Applications Senecionine N-oxide-D3 is a labelled analogue of Senecionine N-oxide (S258655Senecionine N-oxide is the major pyrrolizidine alkaloid in Senecio vulgaris, a native herb of the British Isles. Senecionine N-oxide is hepatotoxic, and is suspected to be an antifertility agent in rats. Despite its toxicity, it is also being regarded as an antiproliferative agent for tumour growth.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hartmann, T. & Toppel, G.: Phytochemistry, 26, 1639 (1987); Su, J., et al.: Org. Mag. Res., 11, 565 (1978); Tu, Z., et al.: J. Pharm. Sci., 77, 461 (1988)

Formula: C₁₈H₂₂D₃NO₆

Colore e forma: White To Brown

Peso molecolare: 354.41

Ref: TR-S258657

Senecionine N-Oxide

CAS: 13268-67-2

Formula: C₁₈H₂₅NO₆

Colore e forma: Neat

Peso molecolare: 351.39

Ref: TR-S258655

Senecionine N-oxide

CAS: 13268-67-2

Senecionine N-oxide is a pyrrolizidine alkaloid N-oxide, which is a naturally occurring chemical compound known for its toxicological properties. It is primarily sourced from plants belonging to the Senecio genus, which are widely distributed across various geographical regions. The mode of action of Senecionine N-oxide involves its bioactivation in the liver, where it is converted to reactive pyrrolic metabolites. These metabolites can form adducts with cellular macromolecules such as DNA and proteins, leading to hepatic necrosis and potentially mutagenic effects.

Formula: C₁₈H₂₅NO₆

Purezza: Min. 95%

Peso molecolare: 351.39 g/mol

Ref: 3D-FS161594

Senecionine N-Oxide

CAS: 13268-67-2

Formula: C₁₈H₂₅NO₆

Peso molecolare: 351.4

Ref: ST-EA-CP-S80001