CAS 133343-34-7: Lattacistina

Descrizione: Lattacistina è un composto che si verifica naturalmente ed è principalmente noto per il suo ruolo come inibitore del proteasoma. È derivato dal batterio *Streptomyces* e ha suscitato interesse nel campo della biochimica e della farmacologia grazie alla sua capacità di inibire selettivamente il proteasoma, un complesso cellulare responsabile della degradazione delle proteine ubiquitinate. Questa inibizione può portare all'accumulo di proteine regolatrici, influenzando così vari processi cellulari, inclusa la regolazione del ciclo cellulare e l'apoptosi. Lattacistina è spesso utilizzato nella ricerca per studiare il ruolo del proteasoma nelle funzioni cellulari e le sue implicazioni in malattie come il cancro e i disturbi neurodegenerativi. Il composto è caratterizzato dalla sua struttura specifica, che include un anello di lattone, contribuendo alla sua attività biologica. Sebbene abbia potenziali applicazioni terapeutiche, l'uso di Lattacistina in contesti clinici è limitato a causa della sua tossicità e della necessità di ulteriori ricerche per comprendere appieno i suoi effetti e meccanismi.

Formula: C₁₅H₂₄N₂O₇S

InChI: InChI=1S/C15H24N2O7S/c1-6(2)10(19)15(11(20)7(3)12(21)17-15)14(24)25-5-9(13(22)23)16-8(4)18/h6-7,9-11,19-20H,5H2,1-4H3,(H,16,18)(H,17,21)(H,22,23)/t7-,9+,10+,11+,15-/m1/s1

InChI key: InChIKey=DAQAKHDKYAWHCG-RWTHQLGUSA-N

SMILES: O=C(O)C(NC(=O)C)CSC(=O)C1(NC(=O)C(C)C1O)C(O)C(C)C

Sinonimi:

• (2R,3S,4R)-3-Hydroxy-2-[(1S)-1-Hydroxy-2-Methylpropyl]-4-Methyl-5-Oxo-2-Pyrrolidinecarboxy-N-Acetyl-L-Cysteine Thioester
• 3S-Hydroxy-2R-(1-Hydroxy-2-Methylpropyl)-4R-Methyl-5-Oxo-2-Pyrrolidinecarboxylate-N-Acetyl-L-Cysteine
• <span class="text-smallcaps">L</smallcap>-Cysteine, N-acetyl-S-[(3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-<smallcap>D</span>-prolyl]-
• <span class="text-smallcaps">L</span>-Cysteine, N-acetyl-, (2R,3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-2-pyrrolidinecarboxylate (ester)
• <span class="text-smallcaps">L</span>-Cysteine, N-acetyl-, 3-hydroxy-2-(1-hydroxy-2-methylpropyl)-4-methyl-5-oxo-2-pyrrolidinecarboxylate (ester), [2R-[2α,2(S*),3α,4α]]-
• Lactacystin (Native)
• Lactacystin, Streptomyces Sp
• Lactacystin, Synthetic
• N-Acetyl-S-[(2R,3S,4R)-3-Hydroxy-2-[(1S)-1-Hydroxy-2-Methylpropyl]-4-Methyl-5-Oxo-2-Pyrrolidinecarbonyl]-L-Cysteine
• N-Acetyl-S-[(3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-<span class="text-smallcaps">D</smallcap>-prolyl]-<smallcap>L</span>-cysteine
• N-acetyl-S-({(2R,3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidin-2-yl}carbonyl)-L-cysteine
• N-acetyl-S-({(2R,3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-3-methylbutyl]-4-methyl-5-oxopyrrolidin-2-yl}carbonyl)-L-cysteine
• N-acetyl-S-({(3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidin-2-yl}carbonyl)-L-cysteine
• N-Acetyl-S-[(3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-D-prolyl]-L-cysteine
• L-Cysteine, N-acetyl-, 3-hydroxy-2-(1-hydroxy-2-methylpropyl)-4-methyl-5-oxo-2-pyrrolidinecarboxylate (ester), [2R-[2α,2(S*),3α,4α]]-
• (+)-LACTACYSTIN
• L-Cysteine, N-acetyl-S-[(3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-D-prolyl]-
• L-Cysteine, N-acetyl-, (2R,3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-2-pyrrolidinecarboxylate (ester)
• Lactacystin

L-Cysteine, N-acetyl-S-[(3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-D-prolyl]-

CAS: 133343-34-7

• Formula: C₁₅H₂₄N₂O₇S
• Colore e forma: Solid
• Peso molecolare: 376.4253

Lactacystin

CAS: 133343-34-7

• Formula: C₁₅H₂₄N₂O₇S
• Purezza: ≥ 95.0%
• Colore e forma: White solid or powder
• Peso molecolare: 376.43

Lactacystin

CAS: 133343-34-7

Lactacystin is an antibiotic Streptomyces spp.

• Formula: C₁₅H₂₄N₂O₇S
• Purezza: 98%
• Colore e forma: White To Off-White Powder
• Peso molecolare: 376.43

Lactacystin

CAS: 133343-34-7

• Formula: C₁₅H₂₄N₂O₇S
• Purezza: 95%~99%
• Colore e forma: Powder
• Peso molecolare: 376.424

(+)-Lactacystin

CAS: 133343-34-7

Applications A selective and potent inhibitor of proteasome-mediated degradation of ubiquitin-tagged proteins. A Streptomyces metabolite …

• Formula: C₁₅H₂₄N₂O₇S
• Colore e forma: Neat
• Peso molecolare: 376.43

Lactacystin

CAS: 133343-34-7

• Purezza: >95%
• Peso molecolare: 376.4200134277344

Lactacystin

CAS: 133343-34-7

Please enquire for more information about Lactacystin including the price, delivery time and more detailed …

• Formula: C₁₅H₂₄N₂O₇S
• Purezza: Min. 95%
• Peso molecolare: 376.43 g/mol

(+)-Lactacystin

CAS: 133343-34-7

Lactacystin is a natural compound that belongs to the class of diketopiperazines. It has been …

• Formula: C₁₅H₂₄N₂O₇S
• Purezza: Min. 95%
• Colore e forma: Powder
• Peso molecolare: 376.43 g/mol