CAS 133407-82-6

N-[(Fenilmetossi)carbonil]-L-leucil-N-[(1S)-1-formil-3-metilbutil]-L-leucinamide

Descrizione:

N-[(Fenilmetossi)carbonil]-L-leucil-N-[(1S)-1-formil-3-metilbutil]-L-leucinamide, con il numero CAS 133407-82-6, è un composto sintetico che appartiene alla classe dei peptidi e dei derivati dei peptidi. Questa sostanza presenta una struttura complessa caratterizzata dalla presenza di due residui di aminoacidi leucina, che contribuiscono alle sue proprietà idrofobiche e alla potenziale attività biologica. Il gruppo fenilmetossicarbonile migliora la sua stabilità e solubilità, mentre il gruppo formile-3-metilbutile può influenzare la sua interazione con obiettivi biologici. Il composto probabilmente mostrerà caratteristiche conformazionali specifiche a causa della presenza di centri chirali, che possono influenzare le sue proprietà farmacologiche. Come derivato peptidico, può avere applicazioni in chimica medicinale, in particolare nello sviluppo di terapie mirate a specifiche vie biologiche. La sua sintesi e caratterizzazione comporterebbero normalmente tecniche standard di accoppiamento di peptidi, e la sua attività potrebbe essere valutata attraverso vari saggi biochimici. In generale, questo composto rappresenta un'area affascinante di studio all'interno della chimica dei peptidi e del design dei farmaci.

Formula: C₂₆H₄₁N₃O₅

InChI: InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1

InChI key: InChIKey=TZYWCYJVHRLUCT-VABKMULXSA-N

SMILES: [C@@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)CC(C)C)=O)(C(N[C@@H](CC(C)C)C=O)=O)CC(C)C

Sinonimi:

• <span class="text-smallcaps">L</smallcap>-Leucinamide, N-[(phenylmethoxy)carbonyl]-<smallcap>L</span>-leucyl-N-(1-formyl-3-methylbutyl)-, (S)-
• <span class="text-smallcaps">L</smallcap>-Leucinamide, N-[(phenylmethoxy)carbonyl]-<smallcap>L</span>-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-
• Calpain Inhibitor IV
• Calpain inhibitor IV-2
• Mg-132
• N-[(Phenylmethoxy)carbonyl]-<span class="text-smallcaps">L</smallcap>-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-<smallcap>L</span>-leucinamide
• N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-4-methyl-1-oxopentan-2-yl]-L-leucinamide
• N-[(benzyloxy)carbonyl]leucyl-N-[(2S)-4-methyl-1-oxopentan-2-yl]leucinamide
• Z-Leu-Leu-Leu-aldehyde
• N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide
• L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-(1-formyl-3-methylbutyl)-, (S)-

MG-132

CAS: 133407-82-6

Formula: C₂₆H₄₁N₃O₅

Purezza: >95.0%(qNMR)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 475.63

Ref: 3B-M3244

MG 132

CAS: 133407-82-6

Inhibitor of calpain proteases

Formula: C₂₆H₄₁N₃O₅

Colore e forma: Crystalline solid

Peso molecolare: 475.63

Ref: 02-J63250

MG 132

CAS: 133407-82-6

Z-LLL-CHO (MG132) was shown to initiate neurite outgrowth in PC12 cells with an optimal concentration of 20 nM and to be a very strong inhibitor of 20S proteasome and of calpain.

Formula: C₂₆H₄₁N₃O₅

Purezza: 92.5%

Colore e forma: White

Peso molecolare: 475.63

Ref: 01-4027888

L-​Leucinamide, N-​[(phenylmethoxy)​carbonyl]​-​L-​leucyl-​N-​[(1S)​-​1-​formyl-​3-​methylbutyl]​-

CAS: 133407-82-6

Formula: C₂₆H₄₁N₃O₅

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 475.6208

Ref: IN-DA0072SK

Calpain inhibitor IV

CAS: 133407-82-6

Calpain inhibitor IV

Formula: C₂₆H₄₁N₃O₅

Purezza: By hplc: 99.17% (Typical Value in Batch COA)

Colore e forma: white to off-white solid

Peso molecolare: 475.62g/mol

Ref: 54-BIC3742

MG-132

CAS: 133407-82-6

MG-132

Purezza: ≥95%

Peso molecolare: 475.62g/mol

Ref: 54-BUP17157

Z-Leu-Leu-Leu-al

CAS: 133407-82-6

Formula: C₂₆H₄₁N₃O₅

Purezza: ≥ 97.0%

Colore e forma: White to off-white powder or solid

Peso molecolare: 475.63

Ref: 7W-GK3641

MG-132

CAS: 133407-82-6

MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor, cell-permeable and reversible,an autophagy activator, induces apoptosis. High-Quality, Low-Cost!

Formula: C₂₆H₄₁N₃O₅

Purezza: 95% - 99.99%

Colore e forma: White To Off-White Powder

Peso molecolare: 475.62

Ref: TM-T2154

MG 132

CAS: 133407-82-6

Stability Hygroscopic
Applications MG 132 is a potent, membrane-permeable proteasome inhibitor. It induces neurite outgrowth in PC12 cells. Neuroprotective product.
References Lee, D., et al.: Trends in Cell Biol., 8, 397 (1998); Tsubuki, S., et al.: J. Biochem., 119., 572 (1996); Grimm, L., et al.: EMBO J., 15, 3835 (1996)

Formula: C₂₆H₄₁N₃O₅

Colore e forma: Neat

Peso molecolare: 475.62

Ref: TR-M340900

Z-Leu-Leu-Leu-H (aldehyde)

CAS: 133407-82-6

Z-Leu-Leu-Leu-H (aldehyde) is an inhibitor that binds to a receptor and prevents the binding of a ligand. This competitive inhibition is reversible and can be used as a research tool to study protein interactions. The high purity of this product makes it ideal for use in pharmacology, cell biology, and life science research.

Formula: C₂₆H₄₁N₃O₅

Purezza: Min. 95%

Peso molecolare: 475.62 g/mol

Ref: 3D-IZL-3175-V

Abz-Thr-Asn-Met-Lys-His-Met-Ala-Gly-Ala-Ala-Gln-EDDnp

CAS: 133407-82-6

Abz-Thr-Asn-Met-Lys-His-Met-Ala-Gly-Ala-Ala-Gln (EDDNP) is a novel and potent inhibitor of the polymerase chain reaction (PCR). It has been shown to inhibit the activity of DNA polymerases, which are key enzymes in DNA replication. EDDNP binds to the active site of the enzyme and blocks access to the DNA template. In addition, this compound inhibits mitochondrial membrane potential, as well as transcriptional regulation and detoxification enzymes. This compound has also been shown to be effective in vivo in mouse models.

Formula: C₆₁H₉₁N₂₁O₁₉S₂

Purezza: Min. 95%

Peso molecolare: 1,486.66 g/mol

Ref: 3D-SFQ-3916-PI

MG 132

CAS: 133407-82-6

MG 132 is a modified tripeptide that acts as proteasomal inhibitor. In 2006, MG 132 has been experimentally tested in in vitro cell-based and in vivo models for to assess its use in the medical treatment of Parkinson's disease.

Formula: C₂₆H₄₁N₃O₅

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 475.30462

Ref: 3D-FM29307