CAS 13434-13-4

Actinonina

Descrizione:

Actinonina, con il numero CAS 13434-13-4, è un composto che si verifica naturalmente ed è principalmente noto per il suo ruolo come antibiotico. È derivato dal batterio *Streptomyces griseus* e presenta notevoli proprietà antibatteriche, in particolare contro alcune ceppi di batteri. Actinonina agisce inibendo l'enzima aminopeptidasi N, coinvolto nel metabolismo delle proteine, interrompendo così la crescita e la proliferazione batterica. Il composto è caratterizzato dalla sua specifica struttura molecolare, che include un'unica struttura biciclica che contribuisce alla sua attività biologica. Actinonina è stato studiato per le sue potenziali applicazioni terapeutiche, in particolare nel trattamento di infezioni causate da ceppi batterici resistenti. Inoltre, è stato indagato per i suoi effetti su vari sistemi biologici, rendendolo un argomento di interesse in chimica medicinale e farmacologia. Il suo profilo di sicurezza e l'efficacia in contesti clinici continuano a essere aree di ricerca, mentre gli scienziati esplorano i suoi potenziali usi nella medicina moderna.

Formula: C₁₉H₃₅N₃O₅

InChI: InChI=1/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)/t14-,15+,17+/m1/s1

InChI key: InChIKey=XJLATMLVMSFZBN-VYDXJSESSA-N

SMILES: C([C@@H](NC([C@@H](CC(NO)=O)CCCCC)=O)[C@H](C)C)(=O)N1[C@H](CO)CCC1

Sinonimi:

• (2R)-N⁴-Hydroxy-N¹-[(1S)-1-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentylbutanediamide
• (2R)-N~4~-hydroxy-N~1~-{(2S)-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}-2-pentylbutanediamide
• 3-[[1-[[2-(Hydroxymethyl)-1-Pyrrolidinyl]-Carbonyl]-2-Methylpropyl]-Carbamoyl]-Octonohydroxamic Acid
• 3-[[1-[[2-(Hydroxymethyl)-1-Pyrrolidinyl]Carbonyl]-2-Methyl-Propyl]Carbamoyl]Octanohydroxamic Acid
• Actinonine
• Butanediamide, N⁴-hydroxy-N¹-[(1S)-1-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentyl-, (2R)-
• Butanediamide, N⁴-hydroxy-N¹-[1-[[2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentyl-, stereoisomer
• Cona 57
• Hylpropyl)Carbamoyl)-
• N4-Hydroxy-N1-[(1S)-1[[(2S)-2-(hydroxymethyl)-1-pyrroldinyl]carbonyl]-2-methylpropyl]-2-pentyl-,(2R)-(9CI)
• N~4~-hydroxy-N~1~-{1-[2-(hydroxymethyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}-2-pentylbutanediamide
• Octanohydroxamic acid, 3-[[1-[[2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]carbamoyl]-
• Octanohydroxamicacid,3-((1-((2-(Hydroxymethyl)-1-Pyrrolidinyl)Carbonyl)-2-Met
• Ro 06-1467
• (2R)-N4-Hydroxy-N1-[(1S)-1-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentylbutanediamide
• Butanediamide, N4-hydroxy-N1-[(1S)-1-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentyl-, (2R)-
• (-)-ACTINONIN
• Butanediamide, N4-hydroxy-N1-[1-[[2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentyl-, stereoisomer
• (2R)-N'-hydroxy-N-[(2S)-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-3-methyl-1-oxo-butan-2-yl]-2-pentyl-butanediamide
• Actininin
• Butanediamide, N4-hydroxy-N1-(1S)-1-(2S)-2-(hydroxymethyl)-1-pyrrolidinylcarbonyl-2-methylpropyl-2-pentyl-, (2R)-
• (2R)-N'-hydroxy-N-[(2S)-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]-2-pentylbutanediamide
• (R)-N4-Hydroxy-N1-((S)-1-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)-2-pentylsuccinamide
• (2R)-2-[2-(hydroxyamino)-2-keto-ethyl]-N-[(1S)-2-methyl-1-[(2S)-2-methylolpyrrolidine-1-carbonyl]propyl]enanthamide
• (2R)-N4-Hydroxy-N1-[(1S)-1-[[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]carbonyl]-2-Methylpropyl]-2-pentyl-butanediaMide

Actinonin

CAS: 13434-13-4

Formula: C₁₉H₃₅N₃O₅

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 385.4983

Ref: IN-DA00800W

(R)-N4-Hydroxy-N1-((S)-1-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)-2-pentylsuccinamide

CAS: 13434-13-4

(R)-N4-Hydroxy-N1-((S)-1-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)-2-pentylsuccinamide

Purezza: 95%

Peso molecolare: 385.51g/mol

Ref: 54-OR1073265

Actinonin

CAS: 13434-13-4

Formula: C₁₉H₃₅N₃O₅

Purezza: ≥ 97.0%

Colore e forma: White to light yellow powder

Peso molecolare: 385.50

Ref: 7W-GA8851

Actinonin

CAS: 13434-13-4

Actinonin is a natural product with antimicrobial activity. It inhibits the growth of bacteria by binding to their ribosomes and inhibiting protein synthesis. Actinonin has been shown to inhibit the growth of gram-positive species such as Streptococcus pyogenes, group A beta-hemolytic streptococci, and Enterococcus faecalis. Actinonin also inhibits a number of enzymes including target enzymes for antimicrobial agents such as penicillin and erythromycin. Actinonin has been shown to be a potential biomarker for bowel disease in humans by its ability to bind to mitochondria in cells from patients with inflammatory bowel disease. This compound binds to basic proteins, which are found in high concentrations in the cell nucleus of organisms including humans.

Formula: C₁₉H₃₅N₃O₅

Purezza: Min. 95%

Peso molecolare: 385.51 g/mol

Ref: 3D-IAC-4157-PI

(-)-Actinonin

Prodotto controllato

CAS: 13434-13-4

Applications (-)-Actinonin is a bioactive peptide and antibiotic that is a potent inhibitor of aminopeptidase M and leucine aminopeptidase. Actinonin has observed to be an inhibitor of peptide deformylase, meprin A, and thermolysin. Actinonin also inhibits tumor cell invasion and matrix degradation along with displayed antitumor activity in vitro and in vivo as well as acting as an apoptotic inducer.
References Umezawa, H., et al.: J. Antibiot., 38, 1629 (1985), Escobar-Alvarez, S., et al.: J. Mol. Biol., 387, 1211 (2009), Berg, A., et al.: Biochem., 48, 1584 (2009), Kuehlmann, U., et al.: Life Sci., 84, 1 (2009),

Formula: C₁₉H₃₅N₃O₅

Colore e forma: Neat

Peso molecolare: 385.50

Ref: TR-A192000

(-)-Actinonin

CAS: 13434-13-4

Antibiotic peptide; inhibitor of aminopeptidase M and leucine aminopeptidase

Formula: C₁₉H₃₅N₃O₅

Purezza: Min. 95%

Peso molecolare: 385.5 g/mol

Ref: 3D-FA17212

Actinonin

CAS: 13434-13-4

Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM. It also induces apoptosis and inhibits aminopeptidase M, aminopeptidase N, and leucine aminopeptidase, as well as MMP-1, MMP-3, MMP-8, MMP-9, and meprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin exhibits antiproliferative and antitumor activities [1][2][3][4][5].

Formula: C₁₉H₃₅N₃O₅

Colore e forma: Solid

Peso molecolare: 385.5

Ref: TM-T14121