CAS 134381-21-8

Epoxomicina

Descrizione:

Epoxomicina è un potente e selettivo inibitore del proteasoma, noto principalmente per il suo ruolo nella ricerca relativa al cancro e alle malattie neurodegenerative. È un prodotto naturale derivato dalla fermentazione del batterio *Streptomyces*. Il composto presenta un gruppo funzionale epossidico unico, che contribuisce al suo meccanismo d'azione legandosi covalentemente al sito attivo del proteasoma, inibendone così la funzione. Questa inibizione porta all'accumulo di proteine regolatrici e apoptosi nelle cellule tumorali, rendendolo uno strumento prezioso nella ricerca sul cancro. Epoxomicina è stato anche studiato per i suoi potenziali effetti neuroprotettivi, poiché potrebbe influenzare la degradazione delle proteine mal ripiegate associate a disturbi neurodegenerativi. In termini di proprietà fisiche, Epoxomicina è tipicamente caratterizzato dal suo stato solido a temperatura ambiente ed è solubile in solventi organici. Il suo utilizzo in ambienti di laboratorio richiede una manipolazione attenta a causa della sua attività biologica e potenziale tossicità. In generale, Epoxomicina funge da composto importante nello studio della funzione del proteasoma e delle sue implicazioni in varie malattie.

Formula: C₂₈H₅₀N₄O₇

InChI: InChI=1/C28H50N4O7/c1-11-16(5)21(30-27(38)23(17(6)12-2)32(10)19(8)34)25(36)31-26(37)22(18(7)33)29-20(13-15(3)4)24(35)28(9)14-39-28/h15-18,20-23,29,33H,11-14H2,1-10H3,(H,30,38)(H,31,36,37)/t16-,17-,18+,20?,21-,22-,23-,28+/m0/s1

InChI key: InChIKey=DOGIDQKFVLKMLQ-JTHVHQAWSA-N

SMILES: C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N(C(C)=O)C)[C@H](CC)C)=O)[C@H](CC)C)=O)[C@@H](C)O)=O)CC(C)C)(=O)[C@@]1(C)CO1

Sinonimi:

• (2R)-2-[Acetyl-(N-Methyl-L-Isoleucyl)-L-Isoleucyl-L-Threonyl-L-Leucyl]-2-Methyloxirane
• <span class="text-smallcaps">L</smallcap>-Threoninamide, N-acetyl-N-methyl-<smallcap>L</smallcap>-isoleucyl-<smallcap>L</span>-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-
• <span class="text-smallcaps">L</smallcap>-Threoninamide, N-acetyl-N-methyl-<smallcap>L</smallcap>-isoleucyl-<smallcap>L</span>-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-
• Bu-4061T
• Epoxomicin, Synthetic
• N-Acetyl-N-Methyl-L-Isoleucyl-L-Isoleucyl-N-[(1S)-3-Methyl-1-[[(2R)-2-Methyloxiranyl]Carbonyl]Butyl]-L-Threoninamide
• N-Acetyl-N-methyl-<span class="text-smallcaps">L</smallcap>-isoleucyl-<smallcap>L</smallcap>-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-<smallcap>L</span>-threoninamide
• N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-L-threonyl-N-{2-[(2R)-2-methyloxiran-2-yl]-2-oxoethyl}-L-leucinamide
• N-acetyl-N-methyl-L-isoleucyl-N-{(2S,3R)-3-hydroxy-2-[(3-methyl-1-{[(2R)-2-methyloxiran-2-yl]carbonyl}butyl)amino]butanoyl}-L-isoleucinamide
• N-Acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-threoninamide
• L-Threoninamide, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-
• L-Threoninamide, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-
• Epoxomicin
• Epoxomicin(BU-4061T)
• Aids010837
• CS-1626
• Aids-010837
• Epoxomicin, 97%, a selective proteasome inhibitor
• BU-4061T,Aids010837
• (2S,3S)-2-[[(2S,3S)-2-[acetyl(Methyl)aMino]-3-Methylpentanoyl]aMino]-N-[(2S,3R)-3-hydroxy-2-[[(2S)-4-Methyl-1-[(2R)-2-Methyloxiran-2-yl]-1-oxopentan-2-yl]aMino]butanoyl]-3-MethylpentanaMide
• EPOXOMICIN;BU4061T;BU-4061T
• 134381-21-8 supplier in China

Epoxomicin

CAS: 134381-21-8

Formula: C₂₈H₅₀N₄O₇

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 554.7192

Ref: IN-DA007MB6

Epoxomicin

CAS: 134381-21-8

Epoxomicin

Purezza: ≥98%

Peso molecolare: 554.72g/mol

Ref: 54-BUP08315

Epoxomicin

CAS: 134381-21-8

Formula: C₂₈H₅₀N₄O₇

Purezza: ≥ 98.0%

Colore e forma: White to off-white or light-yellow solid

Peso molecolare: 554.7

Ref: 7W-GL3424

Epoxomicin

CAS: 134381-21-8

Epoxomicin, a selective proteasome inhibitor, chiefly blocks CH-L activity, mildly affecting T-L and PGPH at lower rates.

Formula: C₂₈H₅₀N₄O₇

Purezza: 98.65% - 98.86%

Colore e forma: White To Off-White Solid

Peso molecolare: 554.72

Ref: TM-T6830

Epoxomicin

CAS: 134381-21-8

Epoxomicin is an activator that binds to the ligand-binding site of a receptor. It has been used as a research tool in cell biology, pharmacology, and immunology. Epoxomicin has been shown to inhibit ion channels by binding to them and blocking their activity. This property makes epoxomicin a good candidate for the treatment of epilepsy. Epoxomicin also inhibits protein synthesis through inhibition of ribosomal S6 kinase, which is involved in signal transduction pathways.

Formula: C₂₈H₅₀N₄O₇

Purezza: Min. 95%

Peso molecolare: 554.72 g/mol

Ref: 3D-IEP-4381-V

Epoxomicin

CAS: 134381-21-8

Epoxomicin is a macrolide antibiotic that inhibits the production of inflammatory mediators by suppressing the activity of protein kinase C. Epoxomicin has been shown to have anti-inflammatory properties in low doses. This drug also inhibits the proteasome, an enzyme that breaks down proteins into amino acids or small peptides, and is used as an inhibitor of cancer cell proliferation. Epoxomicin binds to the 20S proteasome at a site that is distinct from that for other proteasome inhibitors such as lactacystin and bortezomib, which are used for cancer treatment. The binding site for epoxomicin is adjacent to the ATP-binding site and may be due to its inhibitory effect on ATP hydrolysis.

Formula: C₂₈H₅₀N₄O₇

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 554.72 g/mol

Ref: 3D-JFA38121