CAS 134395-00-9

Ester tert-butilico di atorvastatina

Descrizione:

Ester tert-butilico di atorvastatina, con il numero CAS 134395-00-9, è un composto chimico che funge da intermediario nella sintesi dell'atorvastatina, un farmaco ampiamente utilizzato per abbassare i livelli di colesterolo. Questo composto è caratterizzato dal suo gruppo funzionale estere, che contribuisce alla sua reattività e alle proprietà di solubilità. Tipicamente, Ester tert-butilico di atorvastatina è un solido bianco a bianco sporco, ed è solubile in solventi organici come metanolo ed etanolo, ma meno solubile in acqua. Il gruppo tert-butilico aumenta la lipofilia della molecola, il che può influenzare le sue proprietà farmacocinetiche. In termini di stabilità, il composto è generalmente stabile in condizioni standard di laboratorio, ma può essere sensibile all'idrolisi in presenza di umidità. Come intermediario, è cruciale nell'industria farmaceutica per la produzione di atorvastatina, che funge da inibitore della HMG-CoA reduttasi, riducendo efficacemente la sintesi del colesterolo nel fegato. Le condizioni adeguate di manipolazione e stoccaggio sono essenziali per mantenere la sua integrità ed efficacia durante i processi di sintesi e formulazione.

Formula: C₃₇H₄₃FN₂O₅

InChI: InChI=1S/C37H43FN2O5/c1-24(2)34-33(36(44)39-28-14-10-7-11-15-28)32(25-12-8-6-9-13-25)35(26-16-18-27(38)19-17-26)40(34)21-20-29(41)22-30(42)23-31(43)45-37(3,4)5/h6-19,24,29-30,41-42H,20-23H2,1-5H3,(H,39,44)/t29-,30-/m1/s1

InChI key: InChIKey=GCPKKGVOCBYRML-LOYHVIPDSA-N

SMILES: C(NC1=CC=CC=C1)(=O)C=2C(=C(N(CC[C@H](C[C@H](CC(OC(C)(C)C)=O)O)O)C2C(C)C)C3=CC=C(F)C=C3)C4=CC=CC=C4

Sinonimi:

• (3R,5R)-7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid tert-butyl ester
• (4R-cis)-1,1-dimethylethyl-6-[2-[2-(4-fluorophenyl)-5-(1-isopropyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dihydroxy-4-acetate
• (R,dR)-2-(4-Fluorophenyl)-,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid 1,1-Dimethylethyl Ester
• 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, 1,1-dimethylethyl ester, (βR,δR)-
• 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, 1,1-dimethylethyl ester, [R-(R*,R*)]-
• L-2
• L2
• Atorvastatin Impurity 21
• (βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-Methylethyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrrole-1-heptanoic Acid 1,1-DiMethylethyl Ester
• (R,dR)-2-(4-Fluorophenyl)-,d-dihydroxy-5-(1-Methylethyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrrole
• Atorvastatin tert-Butyl Ester
• (3R,5R)-tert-Butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)
• Atorvastatin 1
• 7-[2-(4-Fluoro-phenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3,5-dihydroxy-heptanoic Acid tert-Butyl Ester
• (3R,5R)
• -tert-Butyl 7-(2-(4-fluorophenyl)
• (3R,5R)-tert-Butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-
• (4R-cis)-1,1-diMethylethyl-6-[2-[2-(4-fluorophenyl)-5-(1-isopropyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrro-1-yl]ethyl]-2,2-diMethyl-1,3-dihydroxy-4-acetate
• (3R,5R)-tert-Butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbaMoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Atorvastatin tert-Butyl Ester (tert-butyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate)

CAS: 134395-00-9

Heterocyclic compounds with nitrogen hetero-atom(s) only, aromatic or modified aromatic, nesoi

Formula: C₃₇H₄₃FN₂O₅

Colore e forma: White Off-White Solid

Peso molecolare: 614.3156

Ref: 45-1A00830

(3R,5R)-tert-Butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

CAS: 134395-00-9

Formula: C₃₇H₄₃FN₂O₅

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 614.7461

Ref: IN-DA007MB0

Atorvastatin EP Impurity N (Atorvastatin tert-Butyl Ester)

CAS: 134395-00-9

Formula: C₃₇H₄₃FN₂O₅

Colore e forma: White To Off-White Solid

Peso molecolare: 614.76

Ref: 4Z-A-1216

Atorvastatin tert-Butyl Ester

CAS: 134395-00-9

Colore e forma: Neat

Ref: 86-MM0400.35

(bR,deltaR)-Atorvastatin tert-Butyl Ester (>90%)

Prodotto controllato

CAS: 134395-00-9

Applications An impurity arising in the synthesis of Atorvastatin. Atorvastatin Tert Butyl Ester

Formula: C₃₇H₄₃FN₂O₅

Purezza: >90%

Colore e forma: Neat

Peso molecolare: 614.75

Ref: TR-A791740

Atorvastatin EP Impurity N

CAS: 134395-00-9

Formula: C₃₇H₄₃FN₂O₅

Peso molecolare: 614.75

Ref: ST-EA-CP-A32014

Atorvastatin-d5 tert-Butyl Ester

Prodotto controllato

CAS: 134395-00-9

Applications Atorvastatin-d5 tert-Butyl Ester is the labeled analogue of Atorvastatin tert-Butyl Ester (A791740), an impurity arising in the synthesis of Atorvastatin (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993); Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996); Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000)

Formula: C₃₇H₃₈D₅FN₂O₅

Colore e forma: Neat

Peso molecolare: 619.78

Ref: TR-A791742

Atorvastatin tert-butyl ester

CAS: 134395-00-9

Atorvastatin tert-butyl ester is an acid that is used to treat high cholesterol. It is a synthetic statin that inhibits the enzyme HMG-CoA reductase and blocks the production of cholesterol in the liver. This drug is administered orally, as a tablet or capsule, or in liquid form as a suspension. The drug has a bitter taste and evaporation may occur if it comes into contact with skin or clothes. Atorvastatin tert-butyl ester may be found in polymorphic forms (including dihydropyridine, dihydrospirocyclopentane, and dihydrobenzoquinoline). These forms are inactive, but can be activated by exposure to light or heat. These reactions produce an acidic compound that can react with other compounds to form new compounds.

Formula: C₃₇H₄₃FN₂O₅

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 614.75 g/mol

Ref: 3D-IA18024