CAS 134404-52-7

Seocalcitol

Descrizione:

Seocalcitol, noto anche come 1α,25-diidrossivitamina D3 o il suo analogo, è un derivato sintetico della vitamina D3, utilizzato principalmente nel trattamento di alcune condizioni cutanee, in particolare la psoriasi. Mostra proprietà simili a quelle della vitamina D naturale, inclusa la capacità di regolare il metabolismo del calcio e del fosfato nel corpo. Seocalcitol funziona legandosi ai recettori della vitamina D, influenzando l'espressione genica e promuovendo la differenziazione e la proliferazione cellulare. I suoi effetti terapeutici sono attribuiti alla sua capacità di modulare le risposte immunitarie e inibire la proliferazione dei cheratinociti, rendendolo utile nelle applicazioni dermatologiche. Il composto viene tipicamente somministrato topicamente e la sua efficacia viene spesso valutata in contesti clinici. Come altri analoghi della vitamina D, gli effetti collaterali potenziali possono includere ipercalcemia e irritazione della pelle, richiedendo un attento monitoraggio durante il trattamento. In generale, Seocalcitol rappresenta uno strumento importante nella gestione della psoriasi e di altri disturbi cutanei correlati, sfruttando l'attività biologica della vitamina D in modo controllato.

Formula: C₃₀H₄₆O₃

InChI: InChI=1/C30H46O3/c1-6-30(33,7-2)18-9-8-11-21(3)26-15-16-27-23(12-10-17-29(26,27)5)13-14-24-19-25(31)20-28(32)22(24)4/h8-9,11,13-14,18,21,25-28,31-33H,4,6-7,10,12,15-17,19-20H2,1-3,5H3/b11-8+,18-9+,23-13-,24-14+/t21-,25-,26-,27+,28+,29-/m1/s1

InChI key: InChIKey=LVLLALCJVJNGQQ-SEODYNFXSA-N

SMILES: C[C@@]12[C@](\C(=C\C=C\3/C(=C)[C@@H](O)C[C@H](O)C3)\CCC1)(CC[C@@]2([C@@H](/C=C/C=C/C(CC)(CC)O)C)[H])[H]

Sinonimi:

• (1R,3S,5E)-5-[(2Z)-2-{(1R,3aS,7aR)-1-[(1R,2E,4E)-6-ethyl-6-hydroxy-1-methylocta-2,4-dien-1-yl]-7a-methyloctahydro-4H-inden-4-ylidene}ethylidene]-4-methylidenecyclohexane-1,3-diol (non-preferred name)
• (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol
• (5Z,7E,22E,24E)-24a,26a,27a-Trihomo-9,10-secocholesta-5,7,10(19),22,24-pentaene-1alpha,3beta,25-triol
• 1(S),3(R)-Dihydroxy-20(R)-(5'-ethyl-5'-hydroxyhepta-1'(E),3'(E)-dien-1'-yl)-9,10-secopregna-5(Z),7(E),10(19)-triene
• 1,3-Cyclohexanediol, 5-((1-(6-ethyl-6-hydroxy-1-methyl-2,4-octadienyl)octahydro-7a-methyl-4H-inden-4-ylidene)ethylidene)-4-methylene-, (1R-(1alpha(1R*,2E,4E),3abeta,4E(1R*,3S*,5Z),7aalpha))-
• 1,3-Cyclohexanediol, 5-((2E)-((1R,3aS,7aR)-1-((1R,2E,4E)-6-ethyl-6-hydroxy-1-methyl-2,4-octadienyl)octahydro-7a-methyl-4H-inden-4-ylidene)ethylidene)-4-methylene-, (1R,3S,5Z)-
• 1,3-Cyclohexanediol, 5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1R,3S,5Z)-
• 1,3-Cyclohexanediol, 5-[[1-(6-ethyl-6-hydroxy-1-methyl-2,4-octadienyl)octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, [1R-[1α(1R*,2E,4E),3aβ,4E(1R*,3S*,5Z),7aα]]-
• Eb 1089
• Seocalcitol [INN:BAN]
• EB 1089,(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]-octahydro-7α-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol
• (1R,3S,5Z)-5-((2E)-((1R,3aS,7aR)-1-((1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadienyl)octahydro-7a-methyl-4H-inden-4-ylidene)ethylidene)-4-methylene-1,3-cyclohexanediol

Seocalcitol

CAS: 134404-52-7

Formula: C₃₀H₄₆O₃

Purezza: 99.51%

Colore e forma: Solid

Peso molecolare: 454.6844

Ref: IN-DA009CEQ

Seocalcitol

CAS: 134404-52-7

Seocalcitol is an analog of vitamin D, binds vitamin D receptor protein from human osteosarcoma MG-63 cells(Kd : 0.27 nM).

Formula: C₃₀H₄₆O₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 454.68

Ref: TM-T19559