CAS 134418-28-3

Deidroandrographolide

Descrizione:

Deidroandrographolide è un composto naturale derivato dalla pianta Andrographis paniculata, comunemente noto per le sue proprietà medicinali. È un lattone diterpenoide biciclico, caratterizzato dalla sua struttura complessa che include più anelli e gruppi funzionali. Questo composto mostra una gamma di attività biologiche, comprese proprietà anti-infiammatorie, antiossidanti e antimicrobiche, rendendolo di interesse nella ricerca farmacologica. Deidroandrographolide è stato studiato per i suoi potenziali effetti terapeutici in varie condizioni, comprese infezioni e malattie infiammatorie. Il suo meccanismo d'azione spesso implica la modulazione delle vie di segnalazione e l'inibizione delle citochine pro-infiammatorie. Inoltre, è noto per interagire con vari bersagli biologici, contribuendo ai suoi diversi effetti farmacologici. Il composto viene tipicamente analizzato utilizzando tecniche come cromatografia e spettroscopia per determinare la sua purezza e concentrazione in contesti di ricerca. In generale, Deidroandrographolide rappresenta un'area significativa di studio nella chimica dei prodotti naturali e nello sviluppo di farmaci, evidenziando l'importanza dei composti derivati dalle piante nella medicina moderna.

Formula: C₂₀H₂₈O₅

InChI: InChI=1/C20H28O4/c1-13-4-7-16-19(2,10-8-17(22)20(16,3)12-21)15(13)6-5-14-9-11-24-18(14)23/h5-6,9,15-17,21-22H,1,4,7-8,10-12H2,2-3H3/b6-5+/t15-,16?,17-,19+,20+/m1/s1

InChI key: InChIKey=YIIRVUDGRKEWBV-CZUXAOBFSA-N

SMILES: C[C@]12[C@@]([C@@](CO)(C)[C@H](O)CC1)(CCC(=C)[C@@H]2C/C=C\3/C(=O)OC=C3)[H]

Sinonimi:

• (2R,5R,10R)-2,17-dihydroxy-20-oxo-9,19-didehydro-5,6,7,8,9,10,15-octahydro-20:5,10-dicycloretinal
• (3E)-3-[2-[(1S,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-2(3H)-furanone
• 14-(P)
• 14-Deoxy-11-dehydroandrographolide
• 2(3H)-Furanone, 3-[2-[(1S,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-, (3E)-
• 2(3H)-Furanone, 3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-, [1R-[1α,2α,4aα,5β(E),8aβ]]-
• DEOXY-11,12-DiDehydroandrographolide
• Dehydroanddrographolide
• Dehydroandrographoline
• andrographolide, Dehydro-
• Dehydroandrographolide
• Dehydrographkide
• 2(3H)-Furanone,3-[2-[(1S,4aS,5R,6R,8aS)-decahydro-

(3E)-3-[2-[(1S,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-2(3H)-furanone

CAS: 134418-28-3

Formula: C₂₀H₂₈O₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 332.4339

Ref: IN-DA009AGI

Dehydroandrographolide

CAS: 134418-28-3

Dehydroandrographolide

Purezza: ≥98%

Peso molecolare: 332.43g/mol

Ref: 54-BUP06369

Dehydroandrographolide

CAS: 134418-28-3

Dehydroandrographolide is a natural compound extracted from herbal medicine Andrographis paniculata (Burm f) Nees.

Formula: C₂₀H₂₈O₄

Purezza: 99.98%

Colore e forma: Solid

Peso molecolare: 332.43

Ref: TM-T2738

Dehydroandrographolide

CAS: 134418-28-3

Dehydroandrographolide is a novel TMEM16A inhibitor and possesses multiple pharmacological activities, including anti-inflammation, anti-cancer, anti-bacterial, anti-virus and anti-hepatitis activity. It possesses activity against HBV DNA replication with IC50 values of 22.58 uM and low SI values of 8.7 ; it can alleviate oxidative stress in LPS-induced acute lung injury possibly by inactivating iNOS.

Formula: C₂₀H₂₈O₄

Purezza: 95%~99%

Peso molecolare: 332.44

Ref: BP-BP0459

Dehydroandrographolide

CAS: 134418-28-3

Formula: C₂₀H₂₈O₄

Purezza: ≥ 98.0%

Colore e forma: White to off-white powder

Peso molecolare: 332.43

Ref: 7W-GP8945

Dehydroandrographolide

CAS: 134418-28-3

Lactone

Formula: C₂₀H₂₈O₄

Purezza: ≥ 95.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 332.44

Ref: 5G-89623

Dehydroandrographoline

CAS: 134418-28-3

Dehydroandrographolide is a natural product that has been used in traditional medicine to treat bowel disease, diabetes, and cancer. This compound is found in the plant Andrographis paniculata and has been shown to inhibit P-glycoprotein (P-gp) efflux transporter activity. Dehydroandrographolide also induces autophagy, which is the process by which cells degrade their own components under conditions of nutrient starvation or other stress. In addition, dehydroandrographolide succinate inhibits potassium channel activity and may be a potential anticancer agent. The analytical method for dehydroandrographolide succinate is based on an acid hydrolysis followed by high performance liquid chromatography with UV detection at λ max 218 nm.

Formula: C₂₀H₂₈O₅

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 348.43 g/mol

Ref: 3D-FD11384