CAS 134523-03-8

Atorvastatina calcio

Descrizione:

Atorvastatina calcio è un composto farmaceutico utilizzato principalmente come agente ipolipemizzante per gestire l'iperlipidemia e ridurre il rischio di malattie cardiovascolari. Appartiene alla classe di farmaci noti come statine, che funzionano inibendo l'enzima HMG-CoA reduttasi, un attore chiave nella biosintesi del colesterolo nel fegato. Questa azione porta a una diminuzione del colesterolo a lipoproteine a bassa densità (LDL) e dei trigliceridi, mentre aumenta i livelli di colesterolo a lipoproteine ad alta densità (HDL). L'atorvastatina viene tipicamente somministrata per via orale ed è ben assorbita nel tratto gastrointestinale. La sua solubilità è influenzata dal pH, con una migliore solubilità in condizioni acide. Il composto è caratterizzato dalla sua formula molecolare, che riflette la sua struttura complessa, ed esiste come sale di calcio per migliorare la sua stabilità e biodisponibilità. Gli effetti collaterali comuni possono includere dolore muscolare, alterazioni degli enzimi epatici e disturbi gastrointestinali. Come per tutti i farmaci, l'atorvastatina deve essere utilizzata sotto supervisione medica, considerando le potenziali interazioni con altri farmaci e i profili di salute individuali dei pazienti.

Formula: C₆₆H₆₈Ca₂F₂N₄O₁₀

InChI: InChI=1/2C33H35FN2O5.2Ca.2H/c2*1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40;;;;/h2*3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40);;;;/q;;;+2;;/p-2/t2*26-,27-;;;;/m11..../s1/r2C33H35FN2O5.CaH2.Ca/c2*1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40;;/h2*3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40);1H2;/q;;;+2/p-2/t2*26-,27-;;/m11../s1

InChI key: InChIKey=BWFCZHDTTAYGNN-CNZCJKERSA-N

SMILES: C(NC1=CC=CC=C1)(=O)C=2C(=C(N(CC[C@H](C[C@H](CC(O)=O)O)O)C2C(C)C)C3=CC=C(F)C=C3)C4=CC=CC=C4.[Ca]

Sinonimi:

• (3R,5R)-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Pheynylcarbamoyl)Pyrrol-1-yl]-3,5-Dihydroheptanoic Acid,calcium salt
• (3R,5R)-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Pheynylcarbamoyl)Pyrrol-1-yl]-3,5�CDihydroheptanoic Acid,calcium salt
• (3R,5R)-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Pheynylcarbamoyl)Pyrrol-1-yl]-3,5�CDihydroheptanoic Acid,calcium salt(L-4)
• (R-(R*,R*))-, Atorvastatin calcium
• 1H-Pyrrole-1-Heptanoicacid,Beta,Delta-Dihydroxy-2-(4-Fluorophenyl)-5-(1-Methy Calciumsalt(2:1),(R-(R*,R*))-Lethyl)-3-Phenyl-4-((Phenylamino)Carbonyl)
• 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-calcium salt (2: 1), (R-(R*,R*))-
• 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, calcium salt (2:1), (βR,δR)-
• 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, calcium salt (2:1), [R-(R*,R*)]-
• 1H-Pyrrole-1-heptanoic acid,beta,delta-dihydroxy-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-calcium salt (2: 1)
• Atocor
• Atoraz
• Atorvastatin Ca
• Atorvastatin Calcium Anhydrous
• Atorvastatin Calsium
• Atorvastatin calcium (USAN)
• Atorvastatin calcium salt
• Atorvastatin hemicalcium
• Atorvastatin hemicalcium salt
• Atorvastatincalcuim
• Beta,Delta-Dihydroxy-2-(4-Fluorophenyl)-5-(1-Methylethyl)-3-Phenyl-4-((Phenylamino)Carbonyl)-Calcium Salt(2:1)
• C08078
• Calcium (betaR,deltaR)-2-(p-fluorophenyl)-beta,delta-dihydroxy-5-isopr opyl-3-phenyl-4-(phenylcarbamoyl)pyrrole-1-heptanoate (1:2)
• Ci-981
• D00887
• Delta-Dihydroxy-2-(4-Fluorophenyl)-5-(1-Methylethyl)-3-Phenyl-4-((Phenylamino)Carbonyl)-Betcalci1H-Pyrrole-1-Heptanoicaci
• Drg-0321
• L-4
• Lipibec
• Lipitor
• Lipitor (TN)
• Lorvast
• Lowlip
• Ls-136974
• Pd 134298-38A
• Pd134298-38A
• Prevencor
• Rotacor
• Sortis
• Storvas
• Tahor
• Torvast
• Ym-548
• [R-(R*, R*)]-7-[2-(4-Fluorophenyl)-5-(1-Methylethyl)-3-Phenyl-4-(Phenylaminocarbonyl)-1H-Pyrrol-1-Yl]-3,5-Dihydroxy-Heptanoic Acid Calcium Salt
• calcium (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-p ropan-2-yl-pyrrol-1-yl]-3,5-dihydroxy-heptanoate
• Atorvastatin calcium
• calciumsalt(2:1),(r-(r*,r*))-lethyl)-3-phenyl-4-((phenylamino)carbonyl)
• (3R ,5R )-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Pheynylcarbamoyl) Pyrrol-1-yl]-3 ,5-Dihydroheptanoic Acid, calcium salt (2:1) Trihydrate
• 3R ,5R )-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Pheynylcarbamoyl) Pyrrol-1-yl]-3 ,5 ydroheptanoic Acid, calcium salt (2:1) Trihydrate
• 1h-pyrrole-1-heptanoicacid,beta,delta-dihydroxy-2-(4-fluorophenyl)-5-(1-methy
• Atrovastatin calcium
• (bR,dR)-2-(4-Fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid
• ATORVASTATINE CADIUM
• 3S,5S-Atorvastatin
• Atorvastatin Calclum
• ATORVASTATIN CALCIUM MM(CRM STANDARD)

Atorvastatin Calcium Salt Trihydrate

CAS: 134523-00-5, 134523-03-8, 344423-98-9

Formula: C₆₆H₆₈CaF₂N₄O₁₀·3H₂O

Purezza: >98.0%(HPLC)(N)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 1,209.41

Ref: 3B-A2476

Atorvastatin Calcium

CAS: 134523-03-8

Colore e forma: Neat

Ref: 61-FOR0400.00

Atorvastatin calcium

CAS: 134523-03-8

Atorvastatin calcium

Formula: C₆₆H₆₈CaF₂N₄O₁₀

Purezza: 95.1%

Colore e forma: White

Peso molecolare: 1154.45294

Ref: 47-1267

1H-Pyrrole-1-heptanoicacid,2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-,calciumsalt(2:1),(βR,δR)-

CAS: 134523-03-8

Formula: C₆₆H₆₈CaF₂N₄O₁₀

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 1155.3417

Ref: IN-DA00368S

Atorvastatin Calcium Salt

CAS: 134523-03-8

Formula: C₃₃H₃₄FN₂O₅·5Ca

Colore e forma: White To Off-White Solid

Peso molecolare: 557.65 0.5*40.08

Ref: 4Z-A-121

Atorvastatin calcium salt

CAS: 134523-03-8

Formula: C₃₃H₃₄FN₂O₅·5Ca·5H₂O

Purezza: 98.0 - 102.0 % (anhydrous basis)

Colore e forma: White to almost white crystalline powder

Peso molecolare: 604.69

Ref: 7W-GP5009

Atorvastatin calcium

CAS: 134523-03-8

Formula: C₃₃H₃₄FN₂O₅·Ca

Colore e forma: Neat

Peso molecolare: 1155.34

Ref: 04-C10318000

Atorvastatin Calcium

Prodotto controllato

CAS: 134523-03-8

Formula: C₃₃H₃₄FN₂O₅·Ca

Colore e forma: Neat

Peso molecolare: 1155.34

Ref: 86-MM0400.00

Atorvastatin Impurity 61

CAS: 134523-03-8

Formula: C₄₀H₄₇FN₂O₆

Colore e forma: White To Off-White Solid

Peso molecolare: 670.82

Ref: 4Z-A-12102

Atorvastatin hemicalcium salt

CAS: 134523-03-8

Atorvastatin hemicalcium salt (Atorvastatin Calcium) is an orally HMG-CoA reductase inhibitor that lowers cholesterol. Cost-effective and quality-assured.

Formula: C₃₃H₃₄FN₂O₅Ca

Purezza: 99.27% - >99.99%

Colore e forma: White Crystalline Powder

Peso molecolare: 577.67

Ref: TM-T3116

Atorvastatin Calcium Salt

Prodotto controllato

CAS: 134523-03-8

Applications A selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglyceinhibitorrides in patients with hypercholesterolemia.
References Zhao Y et al. Medicine (Baltimore). 2017 Feb;96(7):e6104.Wu X et al. Carcinogenesis. 2017 Feb 16Sepehri Z et al. PLoS One. 2017 Feb 13;12(2):e0172404

Formula: C₃₃H₃₄FN₂O₅·Ca

Colore e forma: White

Peso molecolare: 1155.34

Ref: TR-A791750

Atorvastatin calcium

CAS: 134523-03-8

HMG-CoA reductase inhibitor; anti-hypercholesterolemia agent

Formula: C₆₆H₆₈CaF₂N₄O₁₀

Purezza: Min. 97 Area-%

Colore e forma: White Powder

Peso molecolare: 1,155.34 g/mol

Ref: 3D-FA57652

Atorvastatin calcium salt - Bio-X ™

CAS: 134523-03-8

Atorvastatin is an HMG-CoA reductase inhibitor that is used to lower lipid levels and to aid in the management of cardiovascular diseases. Animal studies have demonstrated that this drug has vasculoprotective properties.

Formula: (C₃₃H₃₅FN₂O₅)₂•Ca

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 1,157.36 g/mol

Ref: 3D-BA164226