CAS 1346574-57-9

N-[(1,2-Diidro-4,6-dimetil-2-osso-3-piridinil)metil]-3-metil-1-[(1S)-1-metilpropil]-6-[6-(1-piperazinil)-3-piridinil]-1H-indolo-4-carbossamide

Descrizione:

La sostanza chimica N-[(1,2-Diidro-4,6-dimetil-2-osso-3-piridinil)metil]-3-metil-1-[(1S)-1-metilpropil]-6-[6-(1-piperazinil)-3-piridinil]-1H-indolo-4-carbossamide, con numero CAS 1346574-57-9, è un composto organico complesso caratterizzato dalla sua struttura a più anelli, che include moieties di indolo e piridina. Questo composto presenta vari gruppi funzionali, tra cui amidi e chetoni, che contribuiscono alla sua potenziale attività biologica. La presenza di piperazina suggerisce possibili interazioni con bersagli biologici, rendendolo di interesse nella chimica medicinale. La sua struttura molecolare indica una potenziale lipofilia, che può influenzare le sue proprietà farmacocinetiche, come assorbimento e distribuzione nei sistemi biologici. La sintesi e la caratterizzazione del composto normalmente comporterebbero tecniche avanzate di chimica organica, e la sua stabilità, solubilità e reattività sarebbero critiche per applicazioni nello sviluppo di farmaci o nella ricerca. In generale, questa sostanza rappresenta una classe di composti che possono mostrare un significativo potenziale terapeutico, giustificando ulteriori indagini sui suoi effetti biologici e meccanismi d'azione.

Formula: C₃₁H₃₈N₆O₂

InChI: InChI=1S/C31H38N6O2/c1-6-22(5)37-18-20(3)29-25(30(38)34-17-26-19(2)13-21(4)35-31(26)39)14-24(15-27(29)37)23-7-8-28(33-16-23)36-11-9-32-10-12-36/h7-8,13-16,18,22,32H,6,9-12,17H2,1-5H3,(H,34,38)(H,35,39)/t22-/m0/s1

InChI key: InChIKey=FKSFKBQGSFSOSM-QFIPXVFZSA-N

SMILES: [C@@H](CC)(C)N1C=2C(=C(C(NCC3=C(C)C=C(C)NC3=O)=O)C=C(C2)C=4C=CC(=NC4)N5CCNCC5)C(C)=C1

Sinonimi:

• GSK 2816126A
• N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide
• 1H-Indole-4-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-
• N-[(4,6-Dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-((1S)-1-methylpropyl)-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide
• GSK 126
• 1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-methyl-6-(6-piperazin-1-ylpyridin-3-yl)indole-4-carboxamide
• GSK-2816126
• 1-(S)-sec-butyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide
• GSK126, >=98%
• S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide
• N-[(4,6-Dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-((1S)-1-methylpropyl)-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide GSK126

GSK126

CAS: 1346574-57-9

GSK126

Purezza: ≥98%

Peso molecolare: 526.67g/mol

Ref: 54-BUP15338

GSK126

CAS: 1346574-57-9

GSK126

Purezza: 98%

Peso molecolare: 526.67g/mol

Ref: 54-BISN0124

GSK126

CAS: 1346574-57-9

GSK126 (GSK2816126A) is a excellently specific EZH2 methyltransferase inhibitor ( IC50=9.9 nM).

Formula: C₃₁H₃₈N₆O₂

Purezza: 98% - 99.67%

Colore e forma: Solid

Peso molecolare: 526.67

Ref: TM-T2079

GSK 126

CAS: 1346574-57-9

GSK-126 is a potent inhibitor of histone lysine methyl transferase 2, which is encoded by the enhancer of zeste homolog 2 gene (EZH2). The EZH2 protein regulates cell cycle as it represses the Polycomb-Repressive Complex 2 (PRC2), allowing cells to divide actively. GSK-126 inhibits the EZH2 by targeting the catalytic domain (SET) of the enzyme and therefore blocks the PCR2 repression mechanism, resulting in cell proliferation arrest. The compound has shown therapeutic potential for a variety of cancers.

Formula: C₃₁H₃₈N₆O₂

Purezza: Min. 95%

Colore e forma: White To Yellow Solid

Peso molecolare: 526.30562

Ref: 3D-FB43076

GSK126

CAS: 1346574-57-9

Applications GSK126 is a potent and highly selective S-adenosyl-methionine-competitive small molecule inhibitor of EZH2 methyltransferase enzyme activity. The inhibition activity of GSK126 on EZH2 activity may provide a promising treatment for EZH2 mutant lymphoma.
References McCabe, M.T., et al.: Nature., 492, 108 (2012);

Formula: C₃₁H₃₈N₆O₂

Colore e forma: Neat

Peso molecolare: 526.67

Ref: TR-G797650