CAS 13553-79-2

Rifamicina S

Descrizione:

Rifamicina S è un antibiotico naturale appartenente alla classe delle rifamicine, derivato principalmente dal batterio Amycolatopsis rifamycinica. È caratterizzato dalla sua complessa struttura macrociclica, che include un nucleo naftalenico e un cromoforo rifamicina caratteristico. Questo composto mostra una potente attività antibatterica, in particolare contro Mycobacterium tuberculosis, rendendolo significativo nel trattamento della tubercolosi e di altre infezioni batteriche. Rifamicina S agisce inibendo la sintesi dell'RNA batterico attraverso il legame con l'RNA polimerasi dipendente dal DNA, impedendo così la trascrizione. La sostanza viene tipicamente somministrata nelle sue forme derivate, come la rifampicina, che ne migliora le proprietà farmacologiche. Oltre alla sua efficacia antimicrobica, Rifamicina S ha un profilo di tossicità relativamente basso, sebbene possa causare effetti collaterali come l'aumento degli enzimi epatici e reazioni di ipersensibilità in alcuni pazienti. Le sue caratteristiche di solubilità variano, influenzando la sua formulazione e i metodi di somministrazione in contesti clinici. In generale, Rifamicina S è un composto cruciale nel campo della terapia antimicrobica, particolarmente per ceppi batterici resistenti.

Formula: C₃₇H₄₅NO₁₂

InChI: InChI=1/C37H45NO12/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41/h10-16,18-20,25,29-30,33,41-43H,1-9H3,(H,38,46)/b11-10+,14-13+,17-12-/t16-,18+,19+,20+,25-,29-,30+,33+,37-/m0/s1

InChI key: InChIKey=BTVYFIMKUHNOBZ-ODRIEIDWSA-N

SMILES: O=C1C=2C3=C4C(=O)C(=CC3=O)NC(=O)\C(\C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2C(C)=C4O

Sinonimi:

• (14E,24E)-5,17,19-trihydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,6,9,11-tetraoxo-1,2,6,9-tetrahydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate
• (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,17,19-trihydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,6,9,11-tetraoxo-1,2,6,9-tetrahydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate
• 1,4-Dideoxy-1,4-dihydro-1,4-dioxo-rifamycin
• 1,4-Dideoxy-1,4-dihydro-1,4-dioxorifamycin
• 2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,6,9,11(2H)-tetrone, 5,17,19,21-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-, 21-acetate
• 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan, rifamycin deriv.
• 5,17,19-Trihydroxy-23-Methoxy-2,4,12,16,18,20,22-Heptamethyl-1,6,9,11-Tetraoxo-1,2,6,9-Tetrahydro-2,7-(Epoxypentadeca[1,11,13]Trienoimino)Naphtho[2,1-B]Furan-21-Yl Acetate
• Brn 0604802
• Nci 144-130
• Nsc 144130
• Rifamycin, 1,4-dideoxy-1,4-dihydro-1,4-dioxo-
• Rifomycin S
• Unii-Pi53N820Jv
• RIFAMYCIN S
• Rifamycin S CRS
• rifamycin
• RIFAMPICIN S
• 2,7-(epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,6,9,11(2h)-tetron
• 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,6,9,11(2H)-tetrone, 5,17,19,21-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-, 21-acetate (7CI,8CI)
• Rifamycin Impurity 2(Rifamycin EP Impurity B)（Rifamycin S)
• Rifaximin impurity E (EP)
• Rifaximin EP Impurity E (Rifamycin S)
• Rifamycin EP Impurity B
• 5,17,19,21-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-21-aceta
• 100722
• rifomycins
• nci144-130
• 5,17,19,21-Tetrahydroxy-23-Methoxy-2,4,12,16,18,20,22-heptaMethyl-2,7-(epoxypentadeca[1,11,13]trieniMino)naphtho[2,1-b]furan-1,6,9,11(2H)-tetrone 21-Acetate
• Rifamycin S USP/EP/BP
• Rifaximin Impurity 5 (Rifaximin EP Impurity E)
• 4-dideoxy-1,4-dihydro-1,4-dioxo-rifamycin

Rifamycin S

CAS: 13553-79-2

Formula: C₃₇H₄₅NO₁₂

Purezza: >98.0%(HPLC)

Colore e forma: Light yellow to Brown powder to crystal

Peso molecolare: 695.76

Ref: 3B-R0200

RIFAMYCIN S CRS

CAS: 13553-79-2

RIFAMYCIN S CRS

Formula: C₃₇H₄₅NO₁₂

Peso molecolare: 695.7527

Ref: 41-R0950000

2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,6,9,11(2H)-tetrone, 5,17,19,21-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-, 21-acetate (7CI,8CI)

CAS: 13553-79-2

Formula: C₃₇H₄₅NO₁₂

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 695.7527

Ref: IN-DA0035KK

Rifaximin EP Impurity E (Rifamycin S)

CAS: 13553-79-2

Formula: C₃₇H₄₅NO₁₂

Colore e forma: Orange Solid

Peso molecolare: 695.76

Ref: 4Z-R-3515

Rifamycin S

CAS: 13553-79-2

Rifamycin S

Purezza: 97%

Peso molecolare: 695.75g/mol

Ref: 54-OR1028901

Rifamycin S

CAS: 13553-79-2

Rifamycin S

Purezza: ≥98%

Peso molecolare: 695.75g/mol

Ref: 54-BUP17022

Rifamycin S

CAS: 13553-79-2

Colore e forma: Neat

Ref: 86-MM3389.02

Rifamycin S

CAS: 13553-79-2

Rifamycin S is a potent DNA-dependent RNA polymerase inhibitor,is a quinone and an antibiotic agnet against Gram-positive bacteria

Formula: C₃₇H₄₅NO₁₂

Purezza: 98.74%

Colore e forma: Yellow Orange Crystalline Powder

Peso molecolare: 695.75

Ref: TM-T8347

Rifamycin S

Prodotto controllato

CAS: 13553-79-2

Impurity Rifaximin EP Impurity E
Applications Rifamycin S (Rifaximin EP Impurity E) is a semi-synthetic antibiotic.
References Li, J., et al.: Bioorg. Med. Chem. Lett., 17, 5510 (2007), Patil, R., et al.: J. Pure & App. Microbiol., 2, 211 (2008),

Formula: C₃₇H₄₅NO₁₂

Colore e forma: Neat

Peso molecolare: 695.75

Ref: TR-R508210

Rifaximin EP Impurity E

CAS: 13553-79-2

Formula: C₃₇H₄₅NO₁₂

Peso molecolare: 695.8

Ref: ST-EA-CP-R42006

Rifamycin S

CAS: 13553-79-2

Rifamycin S is a rifamycin that is used as a model system to study the activity of other drugs. It is also used to treat infectious diseases, such as bowel disease, by inhibiting bacterial growth. Rifamycin S has been shown to have drug interactions with other drugs and can cause acute toxicities in the form of multivariate logistic regression. It has also been shown to inhibit the enzymatic inactivation of a number of antibiotics, such as methicillin and penicillin, which may be due to its ability to bind DNA templates. Rifamycin S has also been shown to have antibacterial effects against some bacteria, including Mycobacterium tuberculosis and Mycobacterium avium.

Formula: C₃₇H₄₅NO₁₂

Purezza: Min. 96 Area-%

Colore e forma: Powder

Peso molecolare: 695.75 g/mol

Ref: 3D-FR151216

Rifamycin S

CAS: 13553-79-2

Purezza: 97%

Peso molecolare: 695.762

Ref: 10-F986385