CAS 135729-76-9

(3aS)-2-(3R)-1-Azabiciclo[2.2.2]ott-3-il-2,3,3a,4,5,6-esaidro-1H-benz[de]isochinolin-1-one cloridrato (1:1)

Formula: C₁₉H₂₅ClN₂O

InChI: InChI=1S/C19H24N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,13,15,17H,1,3,5,7-12H2;1H/t15-,17+;/m1./s1

InChI key: InChIKey=OLDRWYVIKMSFFB-KALLACGZSA-N

SMILES: O=C1C2=C3[C@@](CN1[C@@H]4C5CCN(C4)CC5)(CCCC3=CC=C2)[H].Cl

Sinonimi:

• 1H-Benz[de]isoquinolin-1-one, 2-(3R)-1-azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-, hydrochloride (1:1), (3aS)-
• RS 25233-197
• 1H-Benz[de]isoquinolin-1-one, 2-(1-azabicyclo[2.2.2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-, monohydrochloride, [R-(R*,S*)]-
• (3aS)-2-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one hydrochloride (1:1)
• (S,R)-Palonosetron
• (S)-2-((R)-quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride
• [R-(R*,S*)]-2-(1-Azabicyclo[2.2.2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one monohydrochloride
• Palonosetron HydrochlorideDiastereomers(S.R)
• (3aS)-2-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one Hydrochloride
• (S)-2-((1S,3R,4S)-Quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride
• (S)-2-((S)-quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-
• (3aS)-
• (3aR)-2-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-3a,4,5,6-tetrahydro-3H-benzo[de]isoquinolin-1-one
• Contains up to ~35% (R,R)-isomer
• Palonosetron Impurity C Control
• (3aS)-2-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one
• (3aR)-2-(1-Azabicyclo[2.2.2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-b enzo[de]isoquinolin-1-one hydrochloride (1:1)

Palonosetron Related Compound C ((S)-2-[(3R)-Quinuclidin-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride)

CAS: 135729-76-9

Lactams, nesoi

Formula: C₁₉H₂₄N₂O·HCl

Colore e forma: Off-White White Pale Yellow Solid

Peso molecolare: 332.16554

Ref: 45-1492244

(S)-2-((1S,3R,4S)-Quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride

CAS: 135729-76-9

Formula: C₁₉H₂₅ClN₂O

Purezza: 95%+

Colore e forma: Solid

Peso molecolare: 332.8676

Ref: IN-DA009EH8

Palonosetron USP Related Compound C ((S,R)-Palonosetron HCl)

CAS: 135729-76-9

Formula: C₁₉H₂₄N₂O·HCl

Colore e forma: Off-White Solid

Peso molecolare: 296.41 36.46

Ref: 4Z-P-534

Palonosetron Related Compound C

CAS: 135729-76-9

Formula: C₁₉H₂₄N₂OHCl

Peso molecolare: 296.41 : 36.46

Ref: ST-EA-CP-P14007

(S,R)-Palonosetron Hydrochloride Contains up to ~35% (R,R)-isomer

Prodotto controllato

CAS: 135729-76-9

Stability Hygroscopic
Applications The (S,R)-enantiomer of Palonosetron (P165800), a potent and selective antagonist, with 5-HT3 receptor in vitro. An impurity of Palonosetron.
References Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993), Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995), Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003), Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004), Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004),

Formula: C₁₉H₂₄N₂O·ClH

Colore e forma: Neat

Peso molecolare: 332.87

Ref: TR-P165810