CAS 136553-81-6

B Q-123

Descrizione:

B Q-123, identificato dal suo numero CAS 136553-81-6, è un composto chimico che ha attirato l'attenzione in vari campi, in particolare nella chimica medicinale e nella farmacologia. È caratterizzato dalla sua specifica struttura molecolare, che contribuisce alla sua unica attività biologica. B Q-123 è noto per agire come un antagonista selettivo di determinati recettori, influenzando vari processi fisiologici. La sua solubilità, stabilità e reattività sono fattori importanti che determinano la sua applicazione nella ricerca e nei potenziali usi terapeutici. Inoltre, B Q-123 può mostrare interazioni specifiche con altre biomolecole, che possono essere critiche per la sua funzione nei sistemi biologici. Le linee guida di sicurezza e gestione sono essenziali quando si lavora con questo composto, così come con qualsiasi sostanza chimica, per mitigare eventuali pericoli potenziali. In generale, B Q-123 rappresenta un composto significativo nello studio delle interazioni recettoriali e nello sviluppo terapeutico, sebbene le informazioni dettagliate sulle sue applicazioni ed effetti specifici possano variare in base alla ricerca in corso.

Formula: C₃₁H₄₂N₆O₇

InChI: InChI=1/C31H42N6O7/c1-16(2)12-21-27(40)33-22(13-18-15-32-20-9-6-5-8-19(18)20)28(41)35-23(14-25(38)39)31(44)37-11-7-10-24(37)29(42)36-26(17(3)4)30(43)34-21/h5-6,8-9,15-17,21-24,26,32H,7,10-14H2,1-4H3,(H,33,40)(H,34,43)(H,35,41)(H,36,42)(H,38,39)

SMILES: CC(C)CC1C(=NC(Cc2c[nH]c3ccccc23)C(=NC(CC(=O)O)C(=O)N2CCCC2C(=NC(C(C)C)C(=N1)O)O)O)O

Sinonimi:

• cyclo(D-asp-pro-D-val-leu-D-trp)
• Cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu)
• D-alpha-aspartyl-L-prolyl-D-valyl-N-[(2R)-1-(1H-indol-3-yl)-3-oxopropan-2-yl]-4-methylidene-L-norvalinamide
• cyclo(D-alpha-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl)
• Cyclo(Alpha-Aspartylprolylvalylleucyltryptophyl)
• Bq-123 Sodium Salt
• Cyclo(D-Asp-L-Pro-D-Val-L-Leu-D-Trp-)
• ETA-RECEPTOR ANTAGONIST
• cyclo(Trp-Asp-Pro-Val-Leu)
• BQ-123 >=99%, sodium salt, lyophilized powder
• D-TRP-D-ASP-PRO-D-VAL-LEU
• BQ-123;BQ 123;BQ123
• BQ-518
• Cyclo[D-Asp-L-Pro-D-Val-L-Leu-D-Trp-]
• BQ-123
• C(DTRP-DASP-PRO-DVAL-LEU)
• 2-((3R,6S,9R,12R,17aS)-9-((1H-indol-3-yl)methyl)-6-isobutyl-3-isopropyl-1,4,7,10,13-pentaoxohexadecahydro-1H-pyrrolo[1,2-a][1,4,7,10,13]pentaazacyclopentadecin-12-yl)acetic acid
• Cyclo(D-α-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl
• BQ-123 SYNTHETIC >99% SELECTIVE ETA ENDO THE
• PMZ 2123
• M.W. 610.70 C31H42N6O7
• Cyclo(D-α-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl)
• CYCLO (-D-TRP-D-ASP-PRO-D-VAL-LEU) SODIUM SALT
• 2-[(3R,6R,9S,12R,15S)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]acetic acid
• CYCLO(D-ASP-PRO-D-VAL-LEU-DTRP NA)

BQ-123

CAS: 136553-81-6

BQ-123 is a potent endothelin antagonist with high selectivity for the ET-A receptor subtype.

Formula: C₃₁H₄₂N₆O₇

Purezza: 98.4%

Colore e forma: Yellow

Peso molecolare: 610.71

Ref: 01-4016690

Cyclo(D-α-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl)

CAS: 136553-81-6

Formula: C₃₁H₄₂N₆O₇

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 610.7012

Ref: IN-DA009ARV

2-((3R,6S,9R,12R,17As)-9-((1H-Indol-3-Yl)Methyl)-6-Isobutyl-3-Isopropyl-1,4,7,10,13-Pentaoxohexadecahydro-1H-Pyrrolo[1,2-A][1,4,7,10,13]Pentaazacyclopentadecin-12-Yl)Acetic Acid

CAS: 136553-81-6

2-((3R,6S,9R,12R,17As)-9-((1H-Indol-3-Yl)Methyl)-6-Isobutyl-3-Isopropyl-1,4,7,10,13-Pentaoxohexadecahydro-1H-Pyrrolo[1,2-A][1,4,7,10,13]Pentaazacyclopentadecin-12-Yl)Acetic Acid

Purezza: 98%

Peso molecolare: 610.7g/mol

Ref: 54-OR1023197

BQ-123

CAS: 136553-81-6

BQ-123

Purezza: ≥95%

Peso molecolare: 610.7g/mol

Ref: 54-BUP08189

BQ-123

CAS: 136553-81-6

BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.

Formula: C₃₁H₄₂N₆O₇

Purezza: 99.22% - ≥95%

Colore e forma: Solid

Peso molecolare: 610.7

Ref: TM-T6792

BQ-123-d7

CAS: 136553-81-6

Formula: C₃₁H₃₅D₇N₆O₇

Peso molecolare: 617.75

Ref: 4Z-PB-200002

BQ-123 [Cyclo(D-Trp-D-Asp-Pro-D-Val-Leu)]

CAS: 136553-81-6

Formula: C₃₁H₄₂N₆O₇

Peso molecolare: 610.71

Ref: 4Z-PB-200001

BQ-123-13C6-15N

CAS: 136553-81-6

Formula: C₂₅₁₃C₆H₄₂N₅₁₅NO₇

Peso molecolare: 617.66

Ref: 4Z-PB-200003

BQ-123 Sodium Salt

CAS: 136553-81-6

BQ-123 is a cyclic peptide that blocks the endothelin-A receptor. It has been shown to be an effective treatment for pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and other inflammatory conditions. BQ-123 binds to the endothelin-A receptor, which is located on the surface of cells in many tissues throughout the body. When bound, it inhibits intracellular calcium concentrations by reducing voltage-gated calcium channels and prevents the release of neurotransmitters. BQ-123 also has a stabilizing effect on hydrogen bonds due to its charged side chains. This property may account for its ability to form stable complexes with other proteins, inhibiting their function.
BQ-123 has been shown to have an active binding site on cyclic AMP response element binding protein (CREB) that inhibits CREB activity, thereby reducing protein synthesis. It also blocks cyclic GMP (cGMP)-dependent protein kin

Formula: C₃₁H₄₂N₆O₇

Purezza: Min. 95%

Peso molecolare: 610.70 g/mol

Ref: 3D-PED-3512-PI

BQ-123 Cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu)

CAS: 136553-81-6

BQ-123 is a cyclic peptide that has been shown to have a binding affinity for the serotonin receptor. The binding of BQ-123 to the receptor leads to a reduction in intracellular calcium concentration, which may be due to the inhibition of serine protease activity. This agent also inhibits the production of tumour necrosis factor-α (TNF-α) and has an inhibitory effect on cardiac contractility.

Formula: C₃₁H₄₂N₆O₇

Purezza: Min. 95%

Peso molecolare: 610.7 g/mol

Ref: 3D-FB108394