CAS 137219-37-5

Plitidepsina

Descrizione:

Plitidepsina, con il numero CAS 137219-37-5, è un peptide ciclico sintetico che ha attirato l'attenzione per le sue potenziali applicazioni terapeutiche, in particolare in oncologia e nei trattamenti antivirali. È derivato dall'organismo marino Aplidium albicans e presenta un meccanismo d'azione unico inibendo il fattore di allungamento della traduzione eucariotica 1A (eEF1A), che è cruciale per la sintesi proteica. Questa inibizione porta all'interruzione dei processi cellulari, inducendo infine l'apoptosi nelle cellule tumorali. Plitidepsina ha mostrato promesse in studi preclinici e clinici, in particolare contro vari tipi di cancro e infezioni virali, comprese quelle causate da coronavirus. Il suo profilo farmacologico include una solubilità moderata in acqua e un profilo di sicurezza favorevole, sebbene possano verificarsi effetti collaterali, come con molti agenti terapeutici. Il composto è tipicamente somministrato per via endovenosa e la ricerca in corso continua a esplorare la sua efficacia e sicurezza in diverse popolazioni di pazienti. In generale, Plitidepsina rappresenta un approccio innovativo nella ricerca di trattamenti efficaci contro malattie difficili.

Formula: C₅₇H₈₇N₇O₁₅

InChI: InChI=1/C57H87N7O15/c1-15-33(8)46-44(66)29-45(67)79-49(32(6)7)48(68)34(9)50(69)58-39(26-30(2)3)54(73)64-25-17-19-41(64)56(75)62(13)43(28-37-20-22-38(77-14)23-21-37)57(76)78-36(11)47(52(71)59-46)60-51(70)42(27-31(4)5)61(12)55(74)40-18-16-24-63(40)53(72)35(10)65/h20-23,30-34,36,39-44,46-47,49,66H,15-19,24-29H2,1-14H3,(H,58,69)(H,59,71)(H,60,70)/t33-,34+,36-,39-,40-,41?,42+,43?,44-,46+,47+,49-/m0/s1

Sinonimi:

• Aplidine
• 2-9-Didemnin B, 2-(1-(1,2-dioxopropyl)-L-proline)-
• Aplidin
• Dehydrodidemnin B
• Didemnin A, N-(1-(1,2-dioxopropyl)-L-prolyl)-
• L-Tyrosine, 1-(1,2-dioxopropyl)-L-prolyl-N-methyl-D-leucyl-L-threonyl-(3S,4R,5S)-4-amino-3-hydroxy-5-methylheptanoyl-(2S,4S)-4-hydroxy-2,5-dimethyl-3-oxohexanoyl-L-leucyl-L-prolyl-N,O-dimethyl-, (8-3)-lactone
• 1-(2-oxopropanoyl)-L-prolyl-N-[(6S,7R,10R,11S,15S,17R,20S,25aS)-11-hydroxy-3-(4-methoxybenzyl)-2,6,17-trimethyl-15-(1-methylethyl)-10-[(1S)-1-methylpropyl]-20-(2-methylpropyl)-1,4,8,13,16,18,21-heptaoxodocosahydro-15H-pyrrolo[2,1-f][1,15,4,7,10,20]dioxatetraazacyclotricosin-7-yl]-N2-methyl-D-leucinamide
• 3,6-Anhydro-(N-{(2S,4S)-4-[(3S,4R,5S)-3-hydroxy-4-{[N-(2-oxo-propanoyl)-L-prolyl-N-Methyl-D-leucyl-L-threonyl]aMino}-5-Methyl-heptanoyloxy]-2,5-diMethyl-3-oxohexanoyl}-L-leucyl-L-prolyl-N
• Plitidepsin
• (2S)-N-[(2R)-1-[[(3S,6S,8S,12S,13R,16S,17R,20S,23S)-13-[(2S)-butan-2-yl]-12-hydroxy-20-[(4-methoxyphenyl)methyl]-6,17,21-trimethyl-3-(2-methylpropyl)-2,5,7,10,15,19,22-heptaoxo-8-propan-2-yl-9,18-dioxa-1,4,14,21-tetrazabicyclo[21.3.0]hexacosan-16-yl]amino]-4-methyl-1-oxopentan-2-yl]-N-methyl-1-(2-oxopropanoyl)pyrrolidine-2-carboxamide
• Plitidepsin (Aplidine)
• Plitidepsin top3

Aplidine

CAS: 137219-37-5

Aplidine

Purezza: ≥98%

Peso molecolare: 1110.34g/mol

Ref: 54-BUP03223

Plitidepsin (Aplidine)

CAS: 137219-37-5

Formula: C₅₇H₈₇N₇O₁₅

Peso molecolare: 1110.36

Ref: 4Z-PP-362001

Aplidine

CAS: 137219-37-5

Aplidine possesses antiviral activity against SARS-CoV-2(IC90 = 0.88 nM).

Formula: C₅₇H₈₇N₇O₁₅

Purezza: 99.86%

Colore e forma: Solid

Peso molecolare: 1110.34

Ref: TM-T9715

Plitidepsin

CAS: 137219-37-5

Plitidepsin is a natural product first isolated from a marine tunicate Aplidium albicans. Plitidepsin has anti-cancer properties as it can induce cell cycle arrest, apoptosis and was also reported to have anti-angiogenic properties. Plitidepsin possesses a potent antiviral activity in vitro against SARS-CoV-2 with IC90 = 0.88nM, which results to be 27.5-fold more potent than the RdRp inhibitor remdesivir. Plitidepsin targets the host protein synthesis factor, eEF1A, and was shown to greatly reduce the subgenomic RNA expression during viral infection.

Formula: C₅₇H₈₇N₇O₁₅

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 1,110.34 g/mol

Ref: 3D-FP178389