CAS 137234-62-9

Voriconazolo

Descrizione:

Voriconazolo è un farmaco antifungino utilizzato principalmente per trattare infezioni fungine gravi, in particolare quelle causate da specie di Aspergillus e Candida. Appartiene alla classe degli antifungini triazolici, che funzionano inibendo l'enzima lanosterolo 14α-demetilasi, cruciale per la sintesi dell'ergosterolo nelle membrane cellulari fungine. Voriconazolo è caratterizzato dalla sua attività ad ampio spettro contro vari funghi, rendendolo efficace sia nelle infezioni invasive che non invasive. Il composto viene tipicamente somministrato per via orale o endovenosa ed è noto per la sua buona biodisponibilità e penetrazione nei tessuti. La sua farmacocinetica può essere influenzata da fattori come età, funzione epatica e farmaci concomitanti, richiedendo un attento monitoraggio dei livelli del farmaco in alcuni pazienti. Voriconazolo è anche associato a potenziali effetti collaterali, tra cui disturbi visivi, epatotossicità e reazioni cutanee. A causa del suo specifico meccanismo d'azione e del profilo degli effetti collaterali, Voriconazolo è spesso riservato a casi in cui altri trattamenti antifungini sono inefficaci o inappropriati.

Formula: C₁₆H₁₄F₃N₅O

InChI: InChI=1/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3

InChI key: InChIKey=BCEHBSKCWLPMDN-MGPLVRAMSA-N

SMILES: [C@@]([C@@H](C)C=1C(F)=CN=CN1)(CN2C=NC=N2)(O)C3=C(F)C=C(F)C=C3

Sinonimi:

• (2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol
• (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
• (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol L(-)-Camphorsulfonate
• (αR,βS)-α-(2,4-Difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
• 2-(2,4-Difluorophenyl)-3-(5-Fluoropyrimidin-4-Yl)-1-(1H-1,2,4-Triazol-1-Yl)Butan-2-Ol
• 4-Pyrimidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βS)-
• 4-Pyrimidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, [R-(R*,S*)]-
• Drg 0301
• G-573
• Uk 109496
• Vfend
• Voriconazol
• (2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyriMidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol L(-)-CaMphorsulfonate
• Voriconazole
• UK-10949
• (2R,3S/2S,3R)-3-(5-FLUORO-4-PYRIMIDINYL)-2-(2,4-DIFLUOROPHENYL)-1-(1H-1,2,4-TRIA
• (aR,S)-a-(2,4-Difluorophenyl)-5-fluoro--methyl-a-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol

Voriconazole

CAS: 137234-62-9

Formula: C₁₆H₁₄F₃N₅O

Purezza: >98.0%(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 349.32

Ref: 3B-V0116

Voriconazole

CAS: 137234-62-9

Colore e forma: Neat

Ref: 61-FOR1094.00

Voriconazole 2.0 mg/ml in Methanol

CAS: 137234-62-9

Colore e forma: Single Solution

Ref: 61-AMP1094.00-07

VORICONAZOLE CRS

CAS: 137234-62-9

VORICONAZOLE CRS

Formula: C₁₆H₁₄F₃N₅O

Colore e forma: White. Powder.

Peso molecolare: 349.3105

Ref: 41-Y0001395

Voriconazole

CAS: 137234-62-9

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Formula: C₁₆H₁₄F₃N₅O

Colore e forma: White Powder

Peso molecolare: 349.11504

Ref: 45-1718008

4-Pyrimidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βS)-

CAS: 137234-62-9

Formula: C₁₆H₁₄F₃N₅O

Purezza: 99%

Colore e forma: Solid

Peso molecolare: 349.3105

Ref: IN-DA0012YZ

Voriconazole

CAS: 137234-62-9

Voriconazole (UK-109496) is a triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 CYP3A.

Formula: C₁₆H₁₄F₃N₅O

Purezza: 98% - 99.91%

Colore e forma: White To Off White Crystalline Powder

Peso molecolare: 349.31

Ref: TM-T0120

Voriconazole

CAS: 137234-62-9

Formula: C₁₆H₁₄F₃N₅O

Colore e forma: White To Off-White Solid

Peso molecolare: 349.32

Ref: 4Z-V-101

Voriconazole-d3

CAS: 137234-62-9

Formula: C₁₆H₁₁D₃F₃N₅O

Colore e forma: White To Off-White Solid

Peso molecolare: 352.34

Ref: 4Z-V-1027

Voriconazole

CAS: 137234-62-9

Voriconazole

Purezza: 98%

Peso molecolare: 349.31g/mol

Ref: 54-PC109157

Voriconazole

CAS: 137234-62-9

Voriconazole

Purezza: ≥98%

Peso molecolare: 349.31g/mol

Ref: 54-BUP17710

Voriconazole

CAS: 137234-62-9

Formula: C₁₆H₁₄F₃N₅O

Purezza: 98.0 - 102.0 %

Colore e forma: White to off-white crystalline powder

Peso molecolare: 349.31

Ref: 7W-GA6306

Voriconazole

Prodotto controllato

CAS: 137234-62-9

Formula: C₁₆H₁₄F₃N₅O

Colore e forma: Neat

Peso molecolare: 349.31

Ref: 04-C17930000

Voriconazole

Prodotto controllato

CAS: 137234-62-9

Formula: C₁₆H₁₄F₃N₅O

Colore e forma: Neat

Peso molecolare: 349.31

Ref: 86-MM1094.00

Voriconazole Impurity 4

CAS: 137234-62-9

Formula: C₁₆H₁₃ClF₃N₅OHCl

Colore e forma: White To Off-White Solid

Peso molecolare: 383.76 36.46

Ref: 4Z-V-1017

Voriconazole-d6

CAS: 137234-62-9

Formula: C₁₆H₈D₆F₃N₅O

Peso molecolare: 355.35

Ref: 4Z-V-1042

Voriconazole-13C-d3

CAS: 137234-62-9

Formula: C₁₅₁₃CH₁₁D₃F₃N₅O

Peso molecolare: 353.33

Ref: 4Z-V-1044

Voriconazole RS

CAS: 137234-62-9

Colore e forma: White Solid Crystalline Powder

Ref: 2K-1153700021

Voriconazole

CAS: 137234-62-9

Voriconazole is an antifungal drug that inhibits the synthesis of ergosterol, a component of the fungal cell membrane. This agent also has anti-inflammatory effects and can be used to treat infections caused by Candida glabrata. Voriconazole binds to the cytoplasmic membrane, inhibiting sterol biosynthesis, which leads to cell death. It has been shown to be effective in treating infections caused by Cryptococcus neoformans and Aspergillus fumigatus and is currently being evaluated for its effectiveness against other opportunistic fungal infections such as histoplasmosis. Voriconazole is not active against bacterial or viral infections.

Formula: C₁₆H₁₄F₃N₅O

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 349.31 g/mol

Ref: 3D-FV29101

Voriconazole - Bio-X ™

CAS: 137234-62-9

Voriconazole is a synthetic, lipophilic molecule that is used in the treatment of fungal infections. Voriconazole binds to ergosterol which is the major sterol in the cell wall of fungi and inhibits its synthesis, leading to cell death. This drug binds to the enzyme 14α-demethylase allowing the conversion of lanosterol into ergosterol. As a result, this binding leads to the inhibition of ergosterol synthesis, as well as other sterols that are necessary for fungal growth (e.g., squalene).

Formula: C₁₆H₁₄F₃N₅O

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 349.31 g/mol

Ref: 3D-BV164532