CAS 137530-41-7

(+)-2'-Desossi-3'-tio-5-fluorocitidina

Descrizione:

(+)-2'-Desossi-3'-tio-5-fluorocitidina, con il numero CAS 137530-41-7, è un analogo di nucleoside sintetico che incorpora zolfo e fluoro nella sua struttura, modificando il nucleoside naturale citidina. Questo composto presenta un legame tioetere nella posizione 3′ e un atomo di fluoro nella posizione 5′, il che migliora la sua stabilità e altera la sua attività biologica. È studiato principalmente per le sue potenziali proprietà antivirali e antitumorali, poiché può interferire con la sintesi degli acidi nucleici. La presenza dell'atomo di fluoro può aumentare l'affinità del composto per le polimerasi virali, rendendolo un candidato per applicazioni terapeutiche contro alcune infezioni virali. Inoltre, la modifica tioetere può contribuire alla sua resistenza alla degradazione enzimatica. Il composto è tipicamente caratterizzato dalla sua formula molecolare, stereochimica e interazioni specifiche con bersagli biologici, che sono cruciali per comprendere il suo profilo farmacologico. In generale, (+)-2'-Desossi-3'-tio-5-fluorocitidina rappresenta un'area significativa di ricerca in chimica medicinale e sviluppo di farmaci.

Formula: C₈H₁₀FN₃O₃S

InChI: InChI=1S/C8H10FN3O3S/c9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5/h1,5-6,13H,2-3H2,(H2,10,11,14)/t5-,6+/m1/s1

InChI key: InChIKey=XQSPYNMVSIKCOC-RITPCOANSA-N

SMILES: O=C1N([C@@H]2O[C@H](CO)SC2)C=C(F)C(N)=N1

Sinonimi:

• (+)-2′-Deoxy-3′-thia-5-fluorocytidine
• (+)-Ftc
• 1,3-Oxathiolane, 2(1H)-pyrimidinone deriv.
• 1-(2-(Hydroxymethyl)oxathiolan-5-yl)-5-fluorocytosine
• 2',3',5-Ftc
• 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, rel-
• 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, cis-
• 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-
• 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-, (2S-cis)-
• 3'-Thia-2'.3'-dideoxy-5-fluorocytidine
• 4-Amino-5-fluoro-1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
• 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one
• 4-amino-5-fluoro-1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one
• 5-Fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine
• 524W91
• Bw 524W91
• RCV
• Racivir

Emtricitabine Enantiomer (4-amino-5-fluoro-1-((2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one; 5-Fluoro-1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine)

CAS: 137530-41-7

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₈H₁₀FN₃O₃S

Colore e forma: Off-White Solid

Peso molecolare: 247.04269

Ref: 45-1A04620

ent-Emtricitabine

CAS: 137530-41-7

Formula: C₈H₁₀FN₃O₃S

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 247.2467

Ref: IN-DA0013HH

Emtricitabine Enantiomer

CAS: 137530-41-7

Formula: C₈H₁₀FN₃O₃S

Colore e forma: White To Off-White Solid

Peso molecolare: 247.24

Ref: 4Z-E-581

(+)-Emtricitabine

CAS: 137530-41-7

Ref: 7W-GC3631

Emtricitabine IP Impurity D

CAS: 137530-41-7

Formula: C₈H₁₀FN₃O₃S

Peso molecolare: 247.25

Ref: ST-EA-CP-E5001

ent-Emtricitabine

Prodotto controllato

CAS: 137530-41-7

Stability Hygroscopic
Applications A reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500).
References Mellors, J., et al.: Science, 72, 1167 (1996), Reimann, K., et al.: J. Virol., 79, 8878 (2005), Rose, J., et al.: J. Biol. Chem., 280, 7413 (2005), Acierno, P., et al.: J. Immunol., 176, 5338 (2006),

Formula: C₈H₁₀FN₃O₃S

Colore e forma: Neat

Peso molecolare: 247.25

Ref: TR-E525005

(+)-Emtricitabine

CAS: 137530-41-7

Emtricitabine is a synthetic nucleoside analog of cytidine. It is used in the treatment of HIV infection and hepatitis B virus infection. Emtricitabine binds to human DNA polymerase, preventing the incorporation of viral DNA into the host cell's genome. This prevents the virus from multiplying and reproducing, thereby inhibiting the spread of HIV in humans. The drug has been shown to inhibit replication at all stages of HIV-1, including reverse transcription and integration into host cell DNA. Emtricitabine also inhibits replication of other viruses such as herpes simplex virus type 1 (HSV-1) and hepatitis C virus (HCV). Emtricitabine is a prodrug that must be activated by phosphorylation before it can be incorporated into DNA. This activation requires tenofovir alafenamide hemifumarate as an activator, which is an experimental drug with improved bioavailability, reduced renal clearance, and

Formula: C₈H₁₀FN₃O₃S

Purezza: Min. 95%

Peso molecolare: 247.25 g/mol

Ref: 3D-NE16704