CAS 137813-35-5

CICLO(ARG-GLY-ASP-D-PHE-VAL)

Descrizione:

CICLO(ARG-GLY-ASP-D-PHE-VAL), con il numero CAS 137813-35-5, è un peptide ciclico composto da cinque amminoacidi: arginina (Arg), glicina (Gly), acido aspartico (Asp), D-fenilalanina (D-Phe) e valina (Val). La struttura ciclica si forma collegando i gruppi amminici e carbossilici terminali, il che ne migliora la stabilità rispetto ai peptidi lineari. Questo composto presenta caratteristiche tipiche dei peptidi, come la capacità di interagire con recettori biologici ed enzimi, rendendolo di interesse nella ricerca farmaceutica, in particolare nella progettazione e nello sviluppo di farmaci. La sua sequenza specifica e la natura ciclica possono contribuire a attività biologiche uniche, inclusi ruoli potenziali nella modulazione dei processi cellulari o come impalcatura per la somministrazione di farmaci. Inoltre, la presenza di amminoacidi D, come D-Phe, può influenzare la resistenza del peptide alla degradazione enzimatica, aumentando ulteriormente il suo potenziale terapeutico. In generale, CICLO(ARG-GLY-ASP-D-PHE-VAL) rappresenta un composto prezioso nel campo della chimica medicinale e della ricerca sui peptidi.

Formula: C₂₆H₃₈N₈O₇

Sinonimi:

• Cyclo(Rgdd-Fv)
• Rgdfv Peptide, Cyclic

Cyclo(-Arg-Gly-Asp-D-Phe-Val)

CAS: 137813-35-5

c(RGDfV) is a potent inhibitor of cell adhesion. It inhibited tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats provided the first evidence of its utility in the amelioration of ischemic acute renal failure. c(RGDfV) inhibited tubular obstruction by preventing cell-cell adhesion. Hammes et al. showed that the cyclopeptide can also be used to prevent retinal neovascularization. c(RGDfV) binds to αvβ3 receptors.

Formula: C₂₆H₃₈N₈O₇

Purezza: 96.9%

Colore e forma: White Lyophilisate

Peso molecolare: 574.64

Ref: 01-4026200

Cyclo(Arg-Gly-Asp-D-Phe-Val)

CAS: 137813-35-5

Cyclo(Arg-Gly-Asp-D-Phe-Val) is a peptide inhibitor of protein interactions. It binds to the ligand binding site of receptor and inhibits the activation of this receptor. Cyclo(Arg-Gly-Asp-D-Phe-Val) also binds to antibodies and can be used as a research tool for identifying antibody targets.

Formula: C₂₆H₃₈N₈O₇•CH₃COOH•2H₂O

Purezza: Min. 95%

Peso molecolare: 670.91 g/mol

Ref: 3D-ICA-4304-V

Cyclo(Arg-Gly-Asp-D-Phe-Val)

CAS: 137813-35-5

Cyclo(Arg-Gly-Asp-D-Phe-Val) is a cyclic peptide that inhibits the activity of surface glycoprotein enzymes. It has shown to be effective against malignant brain tumor cells and has anti-angiogenic effects. Cyclo(Arg-Gly-Asp-D-Phe-Val) also inhibits integrin receptor function by binding to the αVβ3 or αVβ5 integrin, which may be useful for biomarker identification. This compound is potent as an antagonist to epidermal growth factor (EGF), which may have potential use in treating benign prostatic hyperplasia.

Formula: C₂₆H₃₈N₈O₇

Purezza: Min. 95%

Peso molecolare: 574.63 g/mol

Ref: 3D-ICA-4304

Cyclo(-Arg-Gly-Asp-D-Phe-Val) trifluoroacetate salt

CAS: 137813-35-5

Cyclo(-Arg-Gly-Asp-D-Phe-Val) trifluoroacetate salt is a basic fibroblast growth factor that has been shown to have proliferative effects on diabetic retinopathy and ocular neovascularization. It binds to integrin receptors on the surface of cells, which are involved in cell adhesion. Cyclo(-Arg-Gly-Asp-D-Phe-Val) trifluoroacetate salt also has antiangiogenic effects and blocks the angiogenesis process by inhibiting the production of epidermal growth factor (EGF). This drug may be useful for treating certain types of cancer such as malignant brain tumors or neuroblastomas, because it can cause neuronal death. Cyclo(-Arg-Gly-Asp-D-Phe-Val) trifluoroacetate salt is a cyclic peptide with a reactive amino acid side chain.

Formula: C₂₆H₃₈N₈O₇

Purezza: Min. 95%

Peso molecolare: 574.63 g/mol

Ref: 3D-FC108714