CAS 1380288-87-8

Pinometostat

Descrizione:

Pinometostat è un inibitore di piccole molecole noto principalmente per il suo ruolo nel mirare all'enzima DOT1L (disruptor of telomeric silencing 1-like), coinvolto nella metilazione dell'istone H3 alla lisina 79. Questo composto ha attirato l'attenzione nel campo della ricerca sul cancro, in particolare per le sue potenziali applicazioni terapeutiche nel trattamento delle leucemie acute, specialmente quelle associate a riarrangiamenti del gene MLL (leucemia a linea mista). Pinometostat presenta caratteristiche tipiche di una terapia mirata, con l'obiettivo di interrompere specifiche vie molecolari che contribuiscono alla tumorigenesi. Il suo meccanismo d'azione implica l'inibizione della metilazione aberrante degli istoni che promuove l'espressione di geni oncogeni. Il composto è stato sottoposto a varie valutazioni precliniche e cliniche per valutare la sua efficacia e il profilo di sicurezza. Come per molti farmaci in fase di sperimentazione, la ricerca continua è fondamentale per comprendere appieno la sua farmacocinetica, i potenziali effetti collaterali e il suo potenziale terapeutico complessivo in oncologia.

Formula: C₃₀H₄₂N₈O₃

InChI: InChI=1S/C30H42N8O3/c1-16(2)37(13-22-25(39)26(40)29(41-22)38-15-34-24-27(31)32-14-33-28(24)38)19-10-17(11-19)6-9-23-35-20-8-7-18(30(3,4)5)12-21(20)36-23/h7-8,12,14-17,19,22,25-26,29,39-40H,6,9-11,13H2,1-5H3,(H,35,36)(H2,31,32,33)/t17-,19+,22-,25-,26-,29-/m1/s1

InChI key: InChIKey=LXFOLMYKSYSZQS-LURJZOHASA-N

SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](CN(C(C)C)[C@H]4C[C@@H](CCC=5NC=6C(N5)=CC=C(C(C)(C)C)C6)C4)[C@H]1O

Sinonimi:

• 9H-Purin-6-amine, 9-[5-deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-β-D-ribofuranosyl]-
• 5′-Deoxy-5′-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]adenosine
• Adenosine, 5′-deoxy-5′-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-
• EPZ 5676
• Pinometostat
• EPZ 005676
• 9-[5-Deoxy-5-[[cis-3-[2-[6-(1,1-diMethylethyl)-1H-benziMidazol-2-yl]ethyl]cyclobutyl](1-Methylethyl)aMino]-β-D-ribofuranosyl]-9H-purin-6-aMine
• (2R,3R,4S,5R)-2-(6-aMino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]iMidazol-2-yl)ethyl)cyclobutyl)(isopropyl)aMino)Methyl)tetrahydrofuran-3,4-diol
• 9-[5-Deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-beta-D-ribofuranosyl]-9H-purin-6-amine

(2R,3R,4S,5R)-2-(6-Amino-9H-purin-9-yl)-5-((((lr,3S)-3-(2-(5-(tert-butyl)-lH-benzo[d]imidazol2yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol

CAS: 1380288-87-8

Formula: C₃₀H₄₂N₈O₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 562.7063

Ref: IN-DA0039K9

Pinometostat

CAS: 1380288-87-8

Pinometostat

Purezza: ≥95%

Peso molecolare: 562.71g/mol

Ref: 54-BUP16320

Pinometostat

CAS: 1380288-87-8

Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor. Pinometostat has antitumor activity. Cost effective and quality assured.

Formula: C₃₀H₄₂N₈O₃

Purezza: 99.19% - 99.86%

Colore e forma: Solid

Peso molecolare: 562.71

Ref: TM-T3099

9-[5-Deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-β-D-ribofuranosyl]-9H- purin-6-amine

CAS: 1380288-87-8

Nilotinib is a small molecule that inhibits the tyrosine kinase activity of TK1, TK2, and TK3. It binds to the ATP-binding site of these kinases and prevents the phosphorylation of the cellular substrate. Nilotinib has been shown to inhibit the proliferation of leukemia cells in vitro, as well as to have antiproliferative effects in vivo. Nilotinib can be used for the treatment of chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). In addition, it has been shown to have synergistic effects with other drugs such as α1-acid glycoprotein inhibitors or methyltransferase inhibitors. Nilotinib can also be used for cases of hepatic steatosis.

Formula: C₃₀H₄₂N₈O₃

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 562.71 g/mol

Ref: 3D-FD146242

(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-{[(propan-2-yl)[(1r,3s)-3-[2-(6-tert-butyl-1H-1,3-benzodiazol-2-yl)ethyl]cyclobutyl]amino]methyl}oxolane-3,4-diol

CAS: 1380288-87-8

Purezza: 98%

Peso molecolare: 562.719

Ref: 10-F979323

9-[5-Deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-β-D-ribofuranosyl]-9H-purin-6-amine

Prodotto controllato

CAS: 1380288-87-8

Applications 9-[5-Deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-β-D-ribofuranosyl]-9H-purin-6-amine, can be used as an adenosine anticancer, and antibiotic analogues.
References Moukha-chafiq, O., et al.: American Chem. Soci., 146 (2013)

Formula: C₃₀H₄₂N₈O₃

Colore e forma: Neat

Peso molecolare: 562.706

Ref: TR-D232835