CAS 138068-37-8

Lepirudina

Descrizione:

Lepirudina è un anticoagulante sintetico derivato dalla saliva della sanguisuga medicinale, Hirudo medicinalis. Funziona come un inibitore diretto della trombina, il che significa che si lega alla trombina e ne impedisce la conversione del fibrinogeno in fibrina, inibendo così la formazione di coaguli di sangue. Lepirudina è utilizzato principalmente in contesti clinici per il trattamento di pazienti con trombocitopenia indotta da eparina (HIT), una condizione in cui la terapia con eparina porta a una diminuzione del conteggio piastrinico e a un aumento del rischio di trombosi. La sostanza è caratterizzata dalla sua alta specificità per la trombina, rendendola efficace nella gestione dei disturbi trombotici. Lepirudina viene somministrato tramite iniezione endovenosa, e la sua farmacocinetica include una emivita relativamente breve, necessitando di un attento monitoraggio dei livelli di anticoagulazione nei pazienti. Gli effetti avversi possono includere complicazioni emorragiche, comuni con gli anticoagulanti, e reazioni di ipersensibilità. In generale, Lepirudina rappresenta un'opzione terapeutica critica nella gestione dell'anticoagulazione, particolarmente per i pazienti con controindicazioni agli anticoagulanti tradizionali come l'eparina.

Formula: C₂₈₇H₄₄₀N₈₀O₁₁₁S₆

InChI: InChI=1/C287H446N80O111S6/c1-24-132(17)225(359-272(462)187(122-483)350-242(432)147(41-30-33-81-289)322-258(448)170(95-197(297)384)317-206(393)108-303-233(423)148(54-67-192(292)379)313-202(389)107-310-240(430)183(118-479)355-278(468)223(130(13)14)357-265(455)174(99-201(301)388)342-266(456)180(115-369)319-208(395)110-304-235(425)150(60-73-212(400)401)323-269(459)184(119-480)352-254(444)165(90-129(11)12)335-270(460)185(120-481)353-253(443)164(89-128(9)10)334-260(450)172(97-199(299)386)340-244(434)151(55-68-193(293)380)315-204(391)106-309-239(429)179(114-368)348-249(439)158(65-78-217(410)411)330-281(471)229(136(21)374)363-273(463)188(123-484)354-263(453)178(103-222(420)421)347-283(473)230(137(22)375)362-264(454)168(93-141-48-52-144(378)53-49-141)346-282(472)228(135(20)373)361-232(422)145(291)86-125(3)4)280(470)345-162(87-126(5)6)236(426)306-111-209(396)320-181(116-370)267(457)344-176(101-220(416)417)238(428)307-105-203(390)316-152(61-74-213(402)403)243(433)321-146(40-29-32-80-288)241(431)339-171(96-198(298)385)259(449)326-153(56-69-194(294)381)250(440)351-186(121-482)271(461)358-224(131(15)16)279(469)364-227(134(19)372)277(467)311-112-205(392)314-149(59-72-211(398)399)234(424)305-113-210(397)356-231(138(23)376)286(476)367-85-37-45-191(367)276(466)331-160(42-31-34-82-290)284(474)365-83-35-43-189(365)274(464)328-154(57-70-195(295)382)248(438)349-182(117-371)268(458)338-169(94-142-104-302-124-312-142)257(447)341-173(98-200(300)387)261(451)343-175(100-219(414)415)237(427)308-109-207(394)318-177(102-221(418)419)262(452)337-166(91-139-38-27-26-28-39-139)255(445)327-155(62-75-214(404)405)245(435)325-159(66-79-218(412)413)251(441)360-226(133(18)25-2)285(475)366-84-36-44-190(366)275(465)329-157(64-77-216(408)409)246(436)324-156(63-76-215(406)407)247(437)336-167(92-140-46-50-143(377)51-47-140)256(446)333-163(88-127(7)8)252(442)332-161(287(477)478)58-71-196(296)383/h26-28,38-39,46-53,104,124-138,145-191,223-231,368-378,479-484H,24-25,29-37,40-45,54-103,105-123,288-291H2,1-23H3,(H2,292,379)(H2,293,380)(H2,294,381)(H2,295,382)(H2,296,383)(H2,297,384)(H2,298,385)(H2,299,386)(H2,300,387)(H2,301,388)(H,302,312)(H,303,423)(H,304,425)(H,305,424)(H,306,426)(H,307,428)(H,308,427)(H,309,429)(H,310,430)(H,311,467)(H,313,389)(H,314,392)(H,315,391)(H,316,390)(H,317,393)(H,318,394)(H,319,395)(H,320,396)(H,321,433)(H,322,448)(H,323,459)(H,324,436)(H,325,435)(H,326,449)(H,327,445)(H,328,464)(H,329,465)(H,330,471)(H,331,466)(H,332,442)(H,333,446)(H,334,450)(H,335,460)(H,336,437)(H,337,452)(H,338,458)(H,339,431)(H,340,434)(H,341,447)(H,342,456)(H,343,451)(H,344,457)(H,345,470)(H,346,472)(H,347,473)(H,348,439)(H,349,438)(H,350,432)(H,351,440)(H,352,444)(H,353,443)(H,354,453)(H,355,468)(H,356,397)(H,357,455)(H,358,461)(H,359,462)(H,360,441)(H,361,422)(H,362,454)(H,363,463)(H,364,469)(H,398,399)(H,400,401)(H,402,403)(H,404,405)(H,406,407)(H,408,409)(H,410,411)(H,412,413)(H,414,415)(H,416,417)(H,418,419)(H,420,421)(H,477,478)/t132-,133-,134+,135+,136+,137+,138+,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,186-,187-,188-,189-,190-,191-,223-,224-,225-,226-,227-,228-,229-,230-,231-/m0/s1

Sinonimi:

• Lepirudin Recombinant

Lepirudin

CAS: 138068-37-8

Synthetic peptide. Lepirudin is an anticoagulant which functions as a direct thrombin inhibitor.

Formula: C₂₈₇H₄₄₀N₈₀O₁₁₁S₆

Purezza: 95.2%

Colore e forma: White Lyophilisate

Peso molecolare: 6979.52

Ref: 01-4048773

Lepirudin acetate salt

CAS: 138068-37-8

Lepirudin acetate salt is a recombinant heparin that inhibits the activity of thrombin, an enzyme that converts fibrinogen to fibrin. Lepirudin acetate salt binds to thrombin and prevents it from binding to its target sites on the fibrinogen molecule. It is used as an anticoagulant in patients with heparin-induced thrombocytopenia. Lepirudin acetate salt has been shown to be effective against hirudin and lepirudin, which are inhibitors of heparins. The drug also inhibits the formation of polymerase chain reaction products by human polymorphonuclear leukocytes in vitro.

Formula: C₂₈₇H₄₄₀N₈₀O₁₁₁S₆

Purezza: Min. 95%

Peso molecolare: 6,979.43 g/mol

Ref: 3D-FL109904

Lepirudin

CAS: 138068-37-8

Lepirudin is a drug used to treat thrombosis and pulmonary embolism. It inhibits the function of thrombin by binding to its active site and preventing it from converting fibrinogen into fibrin. Lepirudin is an inhibitor molecule that binds to human polymorphonuclear leukocytes, which are cells that contain large quantities of protein. The rate constant for the reaction between these two molecules was determined using chromatographic analysis. Lepirudin has been shown to be toxic in animal studies, leading to allergic symptoms such as rash, fever, chills, nausea, and vomiting. These reactions were reduced when given orally as a prodrug.

Formula: C₂₈₇H₄₄₀N₈₀O₁₁₁S₆

Purezza: Min. 95%

Peso molecolare: 6,979.43 g/mol

Ref: 3D-FL168419