CAS 1397-89-3: Amfotericina B

Descrizione: Amfotericina B è un agente antifungino polieno utilizzato principalmente per trattare infezioni fungine gravi, in particolare quelle causate da specie di Candida e Aspergillus. È derivato dal batterio Streptomyces nodosus ed è noto per la sua capacità di legarsi all'ergosterolo, un componente chiave delle membrane cellulari fungine, portando alla rottura della membrana cellulare e, infine, alla morte cellulare. Amfotericina B è caratterizzato dal suo colore marrone-giallastro ed è tipicamente somministrato per via endovenosa a causa della sua scarsa biodisponibilità orale. Ha un peso molecolare relativamente alto ed è solubile in dimetilsolfossido (DMSO) e altri solventi organici, ma poco solubile in acqua. Il farmaco è noto per i suoi potenziali effetti collaterali, tra cui nefrotossicità e reazioni correlate all'infusione, il che richiede un attento monitoraggio durante il trattamento. Amfotericina B è spesso utilizzato in casi gravi in cui altri trattamenti antifungini possono essere inefficaci, rendendolo un'opzione critica nella gestione delle infezioni fungine invasive.

Formula: C₄₇H₇₃NO₁₇

InChI: InChI=1/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1

InChI key: InChIKey=APKFDSVGJQXUKY-INPOYWNPSA-N

SMILES: O=C(O)C1C(O)CC2(O)OC1CC(OC3OC(C)C(O)C(N)C3O)C=CC=CC=CC=CC=CC=CC=CC(C)C(O)C(C)C(OC(=O)CC(O)CC(O)CCC(O)C(O)CC(O)C2)C

Sinonimi:

• (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-b-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylicacid
• (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-β-<span class="text-smallcaps">D</span>-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
• (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
• (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-amino-3,6-dideoxy-beta-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
• 14,39-Dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid, 33-[(3-amino-3,6-dideoxy-β-<span class="text-smallcaps">D</span>-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-, (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-
• 14,39-Dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid, 33-[(3-amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-, (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-
• 14,39-Dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylicacid, 33-[(3-amino-3,6-dideoxy-b-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-,(1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-
• Abelcet
• Abelecet
• AmBisome
• Ampho-Moronal
• Amphocin
• Amphozone
• Apothecon
• Fungilin
• Fungizona
• Fungizone
• Halizon
• Kalsome 10
• LNS-AmB
• Ns 718
• Nsc 527017
• amfotericina B
• amphotericine B
• Amphotericin B

Amphotericin B, Streptomyces nodosus

CAS: 1397-89-3

Amphotericin B, antifungal activity has been used against leishmaniasis caused by protozoan parasites of the …

• Formula: C₄₇H₇₃NO₁₇
• Peso molecolare: 924.09

Amphotericin B, 250 μg/mL in distilled water, sterile-filtered

CAS: 1397-89-3

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. …

Amphotericin B RS

CAS: 1397-89-3

• Formula: C₄₇H₇₃NO₁₇
• Peso molecolare: 924.079

Amphotericin B for peak identification CRS

CAS: 1397-89-3

• Formula: C₄₇H₇₃NO₁₇
• Peso molecolare: 924.079

Amphotericin B CRS

CAS: 1397-89-3

• Formula: C₄₇H₇₃NO₁₇
• Peso molecolare: 924.079

Second International Standard for Amphotericin B

CAS: 1397-89-3

• Formula: C₄₇H₇₃NO₁₇
• Peso molecolare: 924.079

Amphotericin B for microbiological assay CRS

CAS: 1397-89-3

• Formula: C₄₇H₇₃NO₁₇
• Peso molecolare: 924.079

Amphotericin B

CAS: 1397-89-3

Antibiotics nesoi

• Formula: C₄₇H₇₃NO₁₇
• Colore e forma: Yellow Orange Powder
• Peso molecolare: 924.08

AmphotericinB

CAS: 1397-89-3

• Formula: C₄₇H₇₃NO₁₇
• Purezza: 95%
• Colore e forma: Solid
• Peso molecolare: 924.079

Amphotericin B

CAS: 1397-89-3

Amphotericin B (NSC-527017) is a polyene antifungal agent with broad-spectrum activity against many fungal species.

• Formula: C₄₇H₇₃NO₁₇
• Purezza: ≥98% - ≥98%
• Colore e forma: Deep Yellow Prisms Or Needles From N N-Dimethylformamide Physical Description Bright Yellow Powder (Ntp 1992)
• Peso molecolare: 924.08

Amphotericin B, Ph. Eur. grade

CAS: 1397-89-3

• Formula: C₄₇H₇₃NO₁₇
• Purezza: ≤ 2.0% (at 383nm)
• Colore e forma: Yellow or orange powder
• Peso molecolare: 924.10

Amphotericin B

CAS: 1397-89-3

• Formula: C₄₇H₇₃NO₁₇
• Colore e forma: yellow powder
• Peso molecolare: 924.08g/mol

Amphotericin B

CAS: 1397-89-3

• Formula: C₄₇H₇₃NO₁₇
• Colore e forma: Yellow Solid
• Peso molecolare: 924.09

Amphotericin B

CAS: 1397-89-3

• Formula: C₄₇H₇₃NO₁₇
• Purezza: ≥ 750μg/mg (C47H73NO17, dried basis)
• Colore e forma: Yellow to dark yellow or orange powder
• Peso molecolare: 924.10

Amphotericin B

CAS: 1397-89-3

• Formula: C₄₇H₇₃NO₁₇
• Colore e forma: Yellow
• Peso molecolare: 924.08

Amphotericin B

CAS: 1397-89-3

• Formula: C₄₇H₇₃NO₁₇
• Purezza: >80.0%(HPLC)
• Colore e forma: White to Light orange to Yellow powder to crystal
• Peso molecolare: 924.09

Amphotericin B, 85%

CAS: 1397-89-3

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Formula: C₄₇H₇₃NO₁₇
• Purezza: 85%
• Colore e forma: Powder, Yellow to orange
• Peso molecolare: 924.09

Amphotericin B-13C6

CAS: 1397-89-3

• Formula: C₄₇H₇₃O₁₇
• Peso molecolare: 930.04

Amphotericin B (85%)

CAS: 1397-89-3

• Formula: C₄₇H₇₃NO₁₇
• Purezza: 85%
• Colore e forma: Yellow
• Peso molecolare: 924.08

Amphotericin B - Bio-X ™

CAS: 1397-89-3

Amphotericin B is a macrocycle antibiotic with very potent antifungal effects and resistance very rarely …

• Formula: C₄₇H₇₃NO₁₇
• Purezza: Min. 95%
• Colore e forma: Powder
• Peso molecolare: 924.08 g/mol