CAS 1397-89-3

Amfotericina B

Descrizione:

Amfotericina B è un agente antifungino polieno utilizzato principalmente per trattare infezioni fungine gravi, in particolare quelle causate da specie di Candida e Aspergillus. È derivato dal batterio Streptomyces nodosus ed è noto per la sua capacità di legarsi all'ergosterolo, un componente chiave delle membrane cellulari fungine, portando alla rottura della membrana cellulare e, infine, alla morte cellulare. Amfotericina B è caratterizzato dal suo colore marrone-giallastro ed è tipicamente somministrato per via endovenosa a causa della sua scarsa biodisponibilità orale. Ha un peso molecolare relativamente alto ed è solubile in dimetilsolfossido (DMSO) e altri solventi organici, ma poco solubile in acqua. Il farmaco è noto per i suoi potenziali effetti collaterali, tra cui nefrotossicità e reazioni correlate all'infusione, il che richiede un attento monitoraggio durante il trattamento. Amfotericina B è spesso utilizzato in casi gravi in cui altri trattamenti antifungini possono essere inefficaci, rendendolo un'opzione critica nella gestione delle infezioni fungine invasive.

Formula: C₄₇H₇₃NO₁₇

InChI: InChI=1/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1

InChI key: InChIKey=APKFDSVGJQXUKY-INPOYWNPSA-N

SMILES: C(O)(=O)[C@H]1[C@]2(O[C@@](O)(C[C@@H]1O)C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\[C@H](O[C@H]3[C@@H](O)[C@@H](N)[C@H](O)[C@@H](C)O3)C2)[H]

Sinonimi:

• (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-b-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylicacid
• (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-β-<span class="text-smallcaps">D</span>-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
• (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
• (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-amino-3,6-dideoxy-beta-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
• 14,39-Dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid, 33-[(3-amino-3,6-dideoxy-β-<span class="text-smallcaps">D</span>-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-, (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-
• 14,39-Dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid, 33-[(3-amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-, (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-
• 14,39-Dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylicacid, 33-[(3-amino-3,6-dideoxy-b-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-,(1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-
• Abelcet
• Abelecet
• AmBisome
• Ampho-Moronal
• Amphocin
• Amphozone
• Apothecon
• Fungilin
• Fungizona
• Fungizone
• Halizon
• Kalsome 10
• LNS-AmB
• Ns 718
• Nsc 527017
• amfotericina B
• amphotericine B
• Amphotericin B
• 17,37-octahydroxy-15,16,18-trimethyl-13-oxo-(1r-(1r*,3s*,5r*,6r*,9r*,11r*,15s*
• 14,39-dioxabicyclo(33.3.1)nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carbo
• AMPHOTERICIN B, STREPTOMYCES NODOSUS
• AMPHOTERICIN B, STREPTOMYCES SPECIES
• FUNGIZONE(R)
• AMPHOTERCIN B
• amphotericineb
• AMPHOTERICIN B SOLUBILIZED
• 33-((3-amino-3,6-dideoxy-beta-d-mannopyranosyl)oxy)-1,3,5,6,9,11,-xylicaci
• 33-[(3-amino-3,6-dideoxy-beta-d-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
• AMPHOTERICIN B, SOLUBLE
• amphomoronal
• ,16r*,17r*,18s*,19e,21e,23e,25e-27e,29e,31e,33r*,35s*,36r*,37s*))-

Amphotericin B, 250 &mu;g/mL in distilled water, sterile-filtered

CAS: 1397-89-3

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Ref: 02-J67049

Amphotericin B, Streptomyces nodosus

CAS: 1397-89-3

Amphotericin B, Streptomyces nodosus, 1397-89-3, is a polyene with antibiotic properties which alters cell membrane permeability, leading to lysis and cell death. Learn more.

Formula: C₄₇H₇₃NO₁₇

Peso molecolare: 924.09

Ref: 02-J61491

AMPHOTERICIN B FOR PEAK IDENTIFICATION CRS

CAS: 1397-89-3

AMPHOTERICIN B FOR PEAK IDENTIFICATION CRS

Formula: C₄₇H₇₃NO₁₇

Peso molecolare: 924.079

Ref: 41-Y0001014

AMPHOTERICIN B CRS

CAS: 1397-89-3

AMPHOTERICIN B CRS

Formula: C₄₇H₇₃NO₁₇

Peso molecolare: 924.079

Ref: 41-Y0000005

AMPHOTERICIN B FOR MICROBIOLOGICAL ASSAY CRS

CAS: 1397-89-3

AMPHOTERICIN B FOR MICROBIOLOGICAL ASSAY CRS

Formula: C₄₇H₇₃NO₁₇

Peso molecolare: 924.079

Ref: 41-Y0001361

SECOND INTERNATIONAL STANDARD FOR AMPHOTERICIN B

CAS: 1397-89-3

SECOND INTERNATIONAL STANDARD FOR AMPHOTERICIN B

Formula: C₄₇H₇₃NO₁₇

Peso molecolare: 924.079

Ref: 41-ISA_29078

AMPHOTERICIN B RS

CAS: 1397-89-3

AMPHOTERICIN B RS

Formula: C₄₇H₇₃NO₁₇

Peso molecolare: 924.079

Ref: 41-ICRS0210

Amphotericin B

CAS: 1397-89-3

Antibiotics nesoi

Formula: C₄₇H₇₃NO₁₇

Colore e forma: Yellow Orange Powder

Peso molecolare: 923.48785

Ref: 45-1032007

Amphotericin B

CAS: 1397-89-3

Amphotericin B (NSC-527017) is a polyene antifungal agent with broad-spectrum activity against many fungal species.

Formula: C₄₇H₇₃NO₁₇

Purezza: 99.75% - ≥98%

Colore e forma: Deep Yellow Prisms Or Needles From N N-Dimethylformamide Physical Description Bright Yellow Powder (Ntp 1992)

Peso molecolare: 924.08

Ref: TM-T1067

AmphotericinB

CAS: 1397-89-3

Formula: C₄₇H₇₃NO₁₇

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 924.0790

Ref: IN-DA00ILH6

Amphotericin B

CAS: 1397-89-3

Formula: C₄₇H₇₃NO₁₇

Colore e forma: Yellow Solid

Peso molecolare: 924.09

Ref: 4Z-A-137002

Amphotericin B

CAS: 1397-89-3

Formula: C₄₇H₇₃NO₁₇

Purezza: ≥ 750μg/mg (C47H73NO17, dried basis)

Colore e forma: Yellow to dark yellow or orange powder

Peso molecolare: 924.10

Ref: 7W-GA8986

Amphotericin B, Ph. Eur. grade

CAS: 1397-89-3

Formula: C₄₇H₇₃NO₁₇

Purezza: ≤ 2.0% (at 383nm)

Colore e forma: Yellow or orange powder

Peso molecolare: 924.10

Ref: 7W-GA2492

Amphotericin B

CAS: 1397-89-3

Amphotericin B

Formula: C₄₇H₇₃NO₁₇

Colore e forma: yellow powder

Peso molecolare: 924.07902g/mol

Ref: 54-BIA0103

Amphotericin B

CAS: 1397-89-3

Amphotericin B

Purezza: ≥98%

Peso molecolare: 924.08g/mol

Ref: 54-BUP15128

Amphotericin B

CAS: 1397-89-3

Formula: C₄₇H₇₃NO₁₇

Purezza: >80.0%(HPLC)

Colore e forma: White to Light orange to Yellow powder to crystal

Peso molecolare: 924.09

Ref: 3B-A2114

Amphotericin B

Prodotto controllato

CAS: 1397-89-3

Formula: C₄₇H₇₃NO₁₇

Colore e forma: Neat

Peso molecolare: 924.08

Ref: 04-C10243050

Amphotericin B (85%)

CAS: 1397-89-3

Formula: C₄₇H₇₃NO₁₇

Purezza: 85%

Colore e forma: Yellow

Peso molecolare: 924.08

Ref: TR-A634250

Amphotericin B - Bio-X ™

CAS: 1397-89-3

Amphotericin B is a macrocycle antibiotic with very potent antifungal effects and resistance very rarely occurs. Amphotericin B is a polyene antifungal that binds to fungal cell membrane, i.e., ergosterol disrupts the membrane permeability leading to leakage of intracellular components. It is often used as an alternative therapy for leishmaniasis and to treat severe mycoses including: systemic Candida, Cryptococcus, blastomycosis, and histoplasmosis.

Formula: C₄₇H₇₃NO₁₇

Purezza: Min. 75.0%

Colore e forma: Powder

Peso molecolare: 924.08 g/mol

Ref: 3D-AA15700

Amphotericin B, Antibiotic for Culture Media Use Only

CAS: 1397-89-3

Amphotericin B is a macrocycle antibiotic first isolated from Streptomyces nodosus. Its antifungal activity is exerted by interacting with the fungal membrane, mainly ergosterol, and inducing pore formation. The increase in membrane permeability causes loss of ions and cell death. The C-2’ hydroxyl residue of the mycosamine carbohydrate moiety in the structure seems to have a major role in binding to ergosterol. It is used in cell culture to prevent growth of microbial contaminants, such as yeast and fungi. It is recommended by the WHO and CDC as an antifungal component for VTM at a concentration of 250ug/ml.

Formula: C₄₇H₇₃NO₁₇

Purezza: Min. 80.0 Area-%

Peso molecolare: 924.08 g/mol

Ref: 3D-A-7680