CAS 139893-43-9
:Sale di ammonio di simvastatina
Descrizione:
Sale di ammonio di simvastatina è un derivato della simvastatina, un farmaco ampiamente utilizzato per abbassare il colesterolo che appartiene alla classe delle statine. Questo composto è caratterizzato dalla sua capacità di inibire la HMG-CoA reduttasi, un enzima cruciale per la biosintesi del colesterolo nel fegato. Come sale di ammonio, presenta tipicamente una migliore solubilità in ambienti acquosi rispetto al suo composto originale, il che può migliorare la sua biodisponibilità e l'efficacia terapeutica. La struttura molecolare include un anello di lattone, essenziale per la sua attività biologica, e la presenza di un gruppo ammonio contribuisce alla sua natura ionica. Sale di ammonio di simvastatina è spesso utilizzato in formulazioni farmaceutiche, e la sua stabilità, solubilità e proprietà farmacocinetiche sono critiche per la sua efficacia nella gestione dell'iperlipidemia. Inoltre, può presentare effetti collaterali comuni alle statine, come dolore muscolare o alterazioni degli enzimi epatici, richiedendo monitoraggio durante il trattamento. In generale, Sale di ammonio di simvastatina rappresenta un composto importante nella gestione della salute cardiovascolare.
Formula:C25H40O6·H3N
InChI:InChI=1S/C25H40O6.H3N/c1-6-25(4,5)24(30)31-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-18(26)13-19(27)14-22(28)29;/h7-8,11,15-16,18-21,23,26-27H,6,9-10,12-14H2,1-5H3,(H,28,29);1H3/t15-,16-,18+,19+,20-,21-,23-;/m0./s1
InChI key:InChIKey=FFPDWNBTEIXJJF-OKDJMAGBSA-N
SMILES:O(C(C(CC)(C)C)=O)[C@@H]1[C@]2(C(C=C[C@H](C)[C@@H]2CC[C@H](C[C@H](CC(O)=O)O)O)=C[C@H](C)C1)[H].N
Sinonimi:- (3R,5R)-7-((1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)-3,5-dihydroxyheptanoate ammonium salt
- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a
- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-,d-dihydroxy-2,6-dimethyl-, monoammonium salt, (R,dR,1S,2S,6R,8S,8aR)-
- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, ammonium salt (1:1), (βR,δR,1S,2S,6R,8S,8aR)-
- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, monoammonium salt, (βR,δR,1S,2S,6R,8S,8aR)-
- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, monoammonium salt, [1S-[1α(βS*,δS*),2α,6β,8β,8aα]]-
- Ammonium (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutyryloxy)-1,2,6,7,8,8a-hexahydro-2,6-dimethyl-1-naphthyl]-3,5-dihydroxyheptanoate
- Ammonium simvastatin
- Simvastatin Ammouium Salt
- Simvastatin Hydroxy Acid, Ammonium Salt
- Simvastatin acid ammonium salt
- Simvastatin carboxylic acid ammonium salt
- Simvastatin hydroxyl acid ammonium salt
- Simvastatin impurity A
- Vedi altri sinonimi
Ordinare per
Purezza (%)
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100
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90
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95
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100
13 prodotti.
Ammonium Tenivastatin ((3R,5R)-7-{((1S,2S,6R,8S,8aR)-8-[(2,2)-Dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl}-3,5-dihydroxyheptanoic acid Ammonium Salt)
CAS:Carboxylic acids w/ alcohol function but w/o other oxygen function and their derivatives, nesoiFormula:C25H43NO6Colore e forma:Off-White PowderPeso molecolare:453.30904Simvastatin Hydroxy Acid (ammonium salt)
CAS:Formula:C25H43NO6Purezza:95%Colore e forma:SolidPeso molecolare:453.6120Simvastatin ammonium salt
CAS:Formula:C25H41NO5Purezza:≥ 95.0%Colore e forma:White to light yellow, beige or light brown powderPeso molecolare:435.60Simvastatin EP Impurity A Ammonium Salt (Simvastatin Acid Ammonium Salt, Tenivastatin Ammonium Salt)
CAS:Formula:C25H39O6·NH4Colore e forma:Off-White SolidPeso molecolare:435.58 18.04(3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-[(2,2-Dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic Acid Ammonium Salt (Tenivastatin Ammonium Salt)
CAS:Prodotto controllatoFormula:C25H39O6·H4NColore e forma:NeatPeso molecolare:453.61Ref: ST-EA-CP-S4015
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaSimvastatin Hydroxy Acid Ammonium Salt
CAS:<p>Applications A metabolite of Simvastin (S485000). A competitive inhibitor of HMG-CoA reductase.<br>References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986), Mol, M.J., et al.: Lancet, 2, 936 (1986),<br></p>Formula:C25H43NO6Colore e forma:NeatPeso molecolare:453.61Simvastatin-d6 Hydroxy Acid Ammonium Salt
CAS:Prodotto controllato<p>Applications A deuterated metabolite of Simvastin (S485000). A competitive inhibitor of HMG-CoA reductase.<br>References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986), Mol, M.J., et al.: Lancet, 2, 936 (1986),<br></p>Formula:C25H37D6NO6Colore e forma:White To Light Orange ColourPeso molecolare:459.65Simvastatin acid ammonium
CAS:Simvastatin acid ammonium (Tenivastatin ammonium) is an HMG-CoA reductase (HMGCR) inhibitor.Formula:C25H43NO6Purezza:98.3%Colore e forma:SolidPeso molecolare:453.61Simvastatin hydroxy acid ammonium salt
CAS:<p>Simvastatin is a hydrated, acylated statin that is used as a lipid-lowering drug. It inhibits HMG-CoA reductase, an enzyme that plays a central role in cholesterol biosynthesis. The reaction solution can be activated by mixing with an acyltransferase and the desired acyl group. Simvastatin has a toxicity profile that includes myopathy, rhabdomyolysis, and liver failure. Simvastatin also inhibits lipoprotein lipase and prevents the hydrolysis of triglycerides to fatty acids and glycerol. This leads to reduced levels of low-density lipoproteins (LDLs) and increased levels of high-density lipoproteins (HDLs). Simvastatin is converted into an amide form by enzymatic cleavage, which may lead to metabolic inhibition.</p>Formula:C25H43NO6Purezza:Min. 98 Area-%Colore e forma:White PowderPeso molecolare:453.61 g/mol
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