CAS 1401-69-0

Tilosina

Descrizione:

Tilosina è un antibiotico macrolide utilizzato principalmente in medicina veterinaria, in particolare per il bestiame e il pollame, per trattare infezioni batteriche e promuovere la crescita. È derivato dal batterio *Streptomyces fradiae* e presenta un ampio spettro di attività contro batteri Gram-positivi e alcuni Gram-negativi. Tilosina agisce inibendo la sintesi proteica nei batteri, impedendo così la loro crescita e riproduzione. La sostanza viene tipicamente somministrata sotto forma del suo sale tartrato, che ne migliora la solubilità. Tilosina è noto per la sua relativamente bassa tossicità negli animali, ma il suo uso è regolamentato negli animali da produzione alimentare per prevenire residui di antibiotici nei prodotti a base di carne. Inoltre, è stato studiato per le sue potenziali applicazioni in acquacoltura e come additivo alimentare. La sua struttura chimica presenta un grande anello di lattone, caratteristico dei macrolidi, che contribuisce alle sue proprietà antibatteriche. Come per molti antibiotici, l'emergere di resistenza è una preoccupazione, rendendo necessaria una gestione attenta del suo uso nelle pratiche agricole.

Formula: C₄₆H₇₇NO₁₇

InChI: InChI=1S/C46H77NO17/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35/h14-15,17-18,24-30,32-33,35-45,50,52-55H,13,16,19-22H2,1-12H3/b15-14+,23-18+/t24-,25+,26-,27-,28+,29+,30-,32-,33-,35+,36-,37-,38-,39-,40-,41-,42-,43+,44+,45-,46-/m1/s1

InChI key: InChIKey=WBPYTXDJUQJLPQ-VMXQISHHSA-N

SMILES: O([C@H]1[C@H](N(C)C)[C@@H](O)[C@H](O[C@H]2[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(/C)=C/[C@H](CO[C@H]3[C@H](OC)[C@H](OC)[C@H](O)[C@@H](C)O3)[C@@H](CC)OC(=O)C[C@@H](O)[C@@H]2C)O[C@@H]1C)[C@H]4C[C@@](C)(O)[C@@H](O)[C@H](C)O4

Sinonimi:

• Fradizine
• Oxacyclohexadeca-11,13-diene-7-acetaldehyde, 15-[[(6-deoxy-2,3-di-O-methyl-β-<span class="text-smallcaps">D</smallcap>-allopyranosyl)oxy]methyl]-6-[[3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-α-<smallcap>L</smallcap>-ribo-hexopyranosyl)-3-(dimethylamino)-β-<smallcap>D</span>-glucopyranosyl]oxy]-16-ethyl-4-hydroxy-5,9,13-trimethyl-2,10-dioxo-, [4R-(4R*,5S*,6S*,7R*,9R*,11E,13E,15R*,16R*)]-
• Oxacyclohexadeca-11,13-diene-7-acetaldehyde, 15-[[(6-deoxy-2,3-di-O-methyl-β-D-allopyranosyl)oxy]methyl]-6-[[3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-3-(dimethylamino)-β-D-glucopyranosyl]oxy]-16-ethyl-4-hydroxy-5,9,13-trimethyl-2,10-dioxo-, [4R-(4R*,5S*,6S*,7R*,9R*,11E,13E,15R*,16R*)]-
• Oxacyclohexadecane, tylosin deriv.
• Tilan
• Tilosina
• Tylocine
• Tylosin A
• Tylosin base
• Tylosine
• Vubityl 200
• [(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-{[3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-alpha-L-ribo-hexopyranosyl)-3-(dimethylamino)-beta-D-glucopyranosyl]oxy}-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-2,3-di-O-methyl-beta-D-allopyranoside
• [(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-{[3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-3-(dimethylamino)-β-D-galactopyranosyl]oxy}-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-2,3-di-O-methyl-D-allopyranoside
• [(2R,4E,6E,9R,11R,12S,13S,14R)-12-{[3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-alpha-L-ribo-hexopyranosyl)-3-(dimethylamino)-beta-D-glucopyranosyl]oxy}-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-2,3-di-O-methyl-beta-D-allopyranoside
• [(2R,4E,6E,9R,11R,12S,14R)-12-{[3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-3-(dimethylamino)-β-D-glucopyranosyl]oxy}-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-2,3-di-O-methyl-D-allopyranoside
• [4R-(4R*,5S*,6S*,7R*,9R*,11E,13E,15R*,16R*)]-15-[[(6-Deoxy-2,3-di-O-methyl-β-<span class="text-smallcaps">D</smallcap>-allopyranosyl)oxy]methyl]-6-[[3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-α-<smallcap>L</smallcap>-ribo-hexopyranosyl)-3-(dimethylamino)-β-<smallcap>D</span>-glucopyranosyl]oxy]-16-ethyl-4-hydroxy-5,9,13-trimethyl-2,10-dioxooxacyclohexadeca-11,13-diene-7-acetaldehyde
• [4R-(4R*,5S*,6S*,7R*,9R*,11E,13E,15R*,16R*)]-15-[[(6-Deoxy-2,3-di-O-methyl-β-D-allopyranosyl)oxy]methyl]-6-[[3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-3-(dimethylamino)-β-D-glucopyranosyl]oxy]-16-ethyl-4-hydroxy-5,9,13-trimethyl-2,10-dioxooxacyclohexadeca-11,13-diene-7-acetaldehyde

Tylosin

CAS: 1401-69-0

Tylosin

Colore e forma: Off-White

Ref: 47-349

TYLOSIN CRS

CAS: 1401-69-0

TYLOSIN CRS

Formula: C₄₆H₇₇NO₁₇

Peso molecolare: 916.1001

Ref: 41-T2880000

FIRST INTERNATIONAL STANDARD FOR TYLOSIN

CAS: 1401-69-0

FIRST INTERNATIONAL STANDARD FOR TYLOSIN

Formula: C₄₆H₇₇NO₁₇

Peso molecolare: 916.1001

Ref: 41-ISA_TYN

Tylosin

CAS: 1401-69-0

Antibiotics nesoi

Formula: C₄₆H₇₇NO₁₇

Colore e forma: White Off-White Yellow Powder

Peso molecolare: 916.1 g/mol

Ref: 45-1703805

Tylosin

CAS: 1401-69-0

Formula: C₄₆H₇₇NO₁₇

Purezza: 80%

Colore e forma: Solid

Peso molecolare: 916.1001

Ref: IN-DA00HVQN

Tylosin

CAS: 1401-69-0

Tylosin

Purezza: mixture

Peso molecolare: 916.1g/mol

Ref: 54-BUP14011

Tylosin

CAS: 1401-69-0

Tylosin (Tylosine) is a macrolide antibiotic obtained from cultures of Streptomyces fradiae.

Formula: C₄₆H₇₇NO₁₇

Purezza: mixture - mixture

Colore e forma: Coa

Peso molecolare: 916.10

Ref: TM-T1003

Tylosin

CAS: 1401-69-0

Tylosin

Purezza: 93%

Peso molecolare: 916.1g/mol

Ref: 54-OR1029875

Tylosin

CAS: 1401-69-0

Formula: C₄₆H₇₇NO₁₇

Purezza: ≥ 900IU/mg

Colore e forma: White, almost white or pale yellow powder

Peso molecolare: 916.10

Ref: 7W-GA0812

Tylosin-d3

CAS: 1401-69-0

Formula: C₄₆H₇₄D₃NO₁₇

Peso molecolare: 919.14

Ref: 4Z-T-175002

Tylosin

CAS: 1401-69-0, 8026-48-0

Formula: C₄₆H₇₇NO₁₇

Colore e forma: White To Off-White Solid

Peso molecolare: 916.12

Ref: 4Z-T-175001

Tylosin A 100 µg/mL in Acetonitrile

CAS: 1401-69-0

Formula: C₄₆H₇₇NO₁₇

Colore e forma: Single Solution

Peso molecolare: 916.10

Ref: 04-A17895615AL-100

GB 31660.1-2019 Macrolide Antibiotics Mixture 167 100 µg/mL in Methanol

Prodotto controllato

CAS: 114-07-8, 1401-69-0, 16846-24-5, 2751-09-9, 69-23-8, 8025-81-8, 81103-11-9, 83905-01-5, 93952-07-9

Colore e forma: Mixture

Ref: 04-A50000167ME

Tylosin-d3 (100 Mug/mL in Methanol)

CAS: 1401-69-0

Formula: C₄₆H₇₄D₃NO₁₇

Colore e forma: Colourless

Peso molecolare: 916.10

Ref: TR-KIT9112

Tylosin-d3

Prodotto controllato

CAS: 1401-69-0

Applications Labelled Tylosin (T947650). Tylosin is a macrolide antibiotic isolated from a strain of Streptomycetes fradiae found in soil from Thailand. Antibacterial.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hamill, et al.: Antibiot. Chemother., 11, 328 (1961), Corcoran, J.W., et al.: J. Antibiot., 30, 1012 (1977), Seno, E.T., et al.: Antimicrob. Agents. Chemother., 11, 455 (1977),

Formula: C₄₆H₇₄D₃NO₁₇

Colore e forma: Neat

Peso molecolare: 916.10

Ref: TR-T947652

Tylosin

CAS: 1401-69-0

Stability Light Sensitive
Applications Tylosin is a macrolide antibiotic isolated from a strain of Streptomycetes fradiae found in soil from Thailand. Antibacterial. This compound is a contaminant of emerging concern (CECs).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hamill, et al.: Antibiot. Chemother., 11, 328 (1961), Corcoran, J.W., et al.: J. Antibiot., 30, 1012 (1977), Seno, E.T., et al.: Antimicrob. Agents. Chemother., 11, 455 (1977),

Formula: C₄₆H₇₇NO₁₇

Colore e forma: Off-White

Peso molecolare: 916.10

Ref: TR-T947650

Tylosin

CAS: 1401-69-0

Purezza: 93%+;RG

Peso molecolare: 916.1119995

Ref: 10-F951543