CAS 1405-20-5

polimixina B

Descrizione:

polimixina B è un antibiotico polipeptidico ciclico utilizzato principalmente per trattare infezioni causate da batteri Gram-negativi. È derivato dal batterio Bacillus polymyxa e presenta una struttura unica caratterizzata da una coda idrofobica e un anello peptidico carico positivamente, che gli consente di interrompere le membrane cellulari batteriche. Questa interruzione porta a un aumento della permeabilità e, infine, alla lisi cellulare, rendendolo efficace contro una serie di patogeni, tra cui Pseudomonas aeruginosa ed Escherichia coli. polimixina B è spesso utilizzato in formulazioni topiche a causa della sua nefrotossicità e neurotossicità quando somministrato sistemicamente. Si trova comunemente in unguenti, colliri e altre preparazioni topiche. Inoltre, polimixina B ha attirato l'attenzione nel contesto della resistenza agli antibiotici, poiché a volte viene utilizzato come trattamento di ultima istanza per infezioni multiresistenti. Il suo uso, tuttavia, è limitato da potenziali effetti collaterali e dall'emergere di ceppi batterici resistenti, richiedendo una considerazione attenta nelle applicazioni cliniche.

Formula: C₅₆H₁₀₀N₁₆O₁₇S

InChI: InChI=1/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)

SMILES: CC(C)CC1C(=NC(CCN)C(=NC(CCN)C(=NC(CCO)C(=NCCC(C(=NC(CCN)C(=NC(Cc2ccccc2)C(=N1)O)O)O)N=C(C(CCN)N=C(C(CCO)N=C(C(CCN)N=CO)O)O)O)O)O)O)O.OS(=O)(=O)O

Sinonimi:

• Aerosporin
• Mastimyxin
• N-[3-amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-6-methyl-octanamide,sulfuric acid
• N~2~-[4-amino-2-(formylamino)butanoyl]-N-(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(2-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)homoserinamide sulfate (salt)
• Polymixin B Sulfate
• Polymyxin B (PMB)
• Polymyxin B 2,5-SULFATE
• Polymyxin B Sulphate
• Polymyxin B sulfate salt
• Polymyxin B, Sulfat (Salz)
• Polymyxin B₁-polymyxin B₂ sulfate
• polimixina B, sulfato (sal)
• polymyxin B sulfate
• polymyxine B, sulfate (sel)
• Polimixin B Sulphate
• APPLISORB
• MYP SUPPLEMENT
• LISTERIA MONOCYTOGENES SELECTIVE SUPPLEMENT I
• POLYMYXIN B SULFATE, BACILLUS POLYMYXA
• POLYMIXIN B SULPHATE
• Polymyxin B solution
• LISTERIA MONO SELECTIVE SUPPLEMENT I
• POLYMYXIN B
• polymyxin B standard solution
• BACILLUS CEREUS SELECTIVE SUPPLEMENT
• BACILLUS CEREUS SELECTIVE AGAR BASE

Polymyxin B Sulfate

CAS: 1404-26-8, 1405-20-5

Colore e forma: White to Light yellow powder to crystal

Ref: 3B-P1923

Polymixin B sulfate, Cell Culture Reagent

CAS: 1405-20-5

Polymixin B sulfate, 1405-20-5, is a polypeptide antibiotic which exhibits activity against gram-negative bacteria. Learn more at Thermo Fisher Scientific.

Formula: C₄₈H₈₄N₁₆O₁₇S

Colore e forma: White to pale yellow, Powder

Peso molecolare: 1189.36

Ref: 02-J61763

Polymixin B sulfate

CAS: 1405-20-5

Polymixin B sulfate, 1405-20-5, is a polypeptide antibiotic which exhibits activity against gram-negative bacteria. Learn more at Thermo Fisher Scientific.

Formula: C₄₈H₈₄N₁₆O₁₇S

Colore e forma: Powder or crystalline powder, White to pale yellow

Peso molecolare: 1189.36

Ref: 02-J63074

POLYMYXIN B SULFATE FOR MICROBIOLOGICAL ASSAY CRS

CAS: 1405-20-5

POLYMYXIN B SULFATE FOR MICROBIOLOGICAL ASSAY CRS

Formula: C₅₆H₁₀₀N₁₆O₁₇S

Peso molecolare: 1301.555

Ref: 41-Y0000355

Polymyxin B sulfate

CAS: 1405-20-5

Polymyxin B sulfate

Colore e forma: Colourless

Ref: 47-1028

SECOND INTERNATIONAL STANDARD FOR POLYMYXIN B

CAS: 1405-20-5

SECOND INTERNATIONAL STANDARD FOR POLYMYXIN B

Formula: C₅₆H₁₀₀N₁₆O₁₇S

Peso molecolare: 1301.555

Ref: 41-ISA_67_301

POLYMYXIN B SULFATE CRS

CAS: 1405-20-5

POLYMYXIN B SULFATE CRS

Ref: 41-P2400000

Polymyxin B Sulfate

CAS: 1405-20-5

Antibiotics nesoi

Formula: C₅₆H₉₈N₁₆O₁₃C₅₅H₉₆N₁₆O₁₃C₅₅H₉₆N₁₆O₁₃C₅₆H₉₈N₁₆O₁₃

Colore e forma: White Off-White Powder

Peso molecolare: 4782.96841

Ref: 45-1547007

Polymyxin B, sulfate (salt)

CAS: 1405-20-5

Formula: C₅₆H₁₀₀N₁₆O₁₇S

Colore e forma: Solid

Peso molecolare: 1301.5552

Ref: IN-DA001CJX

Polymyxin B Sulfate

CAS: 1405-20-5

Polymyxin B Sulfate, a mix of B1 and B2 from Bacillus polymyxa, fights gram-negative infections but may harm nerves and kidneys.

Formula: C₅₆H₁₀₀N₁₆O₁₇S

Purezza: 8010u/mg - 98%

Colore e forma: White Crystalline Powder

Peso molecolare: 1301.56

Ref: TM-T1100

Polymixin B sulphate

CAS: 1405-20-5

Polymixin B sulphate

Formula: C₅₆H₉₈N₁₆O₁₃·H₂SO₄

Colore e forma: white to almost white powder

Peso molecolare: 1,301.56g/mol

Ref: 54-BIP0145

Polymixin B sulfate salt

CAS: 1405-20-5

Formula: C₅₅H₉₆N₁₆O₁₃·2H₂SO₄

Purezza: ≥ 6000IU/mg (dried basis)

Colore e forma: White to pale yellow powder

Peso molecolare: 1385.63

Ref: 7W-GA4910

Polymyxin B Sulfate

CAS: 1405-20-5

Polymyxin B Sulfate

Purezza: ≥98%

Peso molecolare: 1301.56g/mol

Ref: 54-BUP19624

Polymyxin B sulfate

Prodotto controllato

CAS: 1405-20-5

Formula: C₅₅H₉₆N₁₆O₁₃· 2H₂SO₄

Colore e forma: White To Off-White

Peso molecolare: 1385.61

Ref: 04-C16283000

Polymyxin B Sulfate

CAS: 1405-20-5

Formula: C₅₆H₉₈N₁₆O₁₃·H₂O₄S

Peso molecolare: 1203.50 98.07

Ref: 4Z-PP-321010

Polymyxin B1 Formate Salt

Prodotto controllato

CAS: 1405-20-5

Formula: C₅₆H₉₈N₁₆O₁₃·xHCOOH

Colore e forma: Off-White

Peso molecolare: 1203.48 + x46.03

Ref: TR-P689406

Polymyxin B Sulfate

CAS: 1405-20-5

Applications Antibiotic with bactericidal action on E. coli. Binds to the lipid A portion of bacterial lipopolysaccharides. Induces pore formation in the membranes of cortex cells from excised sorghum roots. Mixture of Polymyxin B1 and B2 sulfate.
References Coppi, G., et al.: J. Pharm. Pharmacol., 60, 21 (2008), Roche, S., et al.: Food Microbiol., 26, 21 (2008), Kawanishi, T., et al.: Plant Pathol., 58, 237 (2009),

Formula: C₅₅H₉₆N₁₆O₁₃H₂SO₄

Colore e forma: Neat

Peso molecolare: 1385.61

Ref: TR-P689400

Polymyxin B sulfate

CAS: 1405-20-5

Membrane-disrupting agent

Formula: C₅₆H₉₈N₁₆O₁₃·H₂SO₄

Purezza: Min 6000 Iu/Mg

Colore e forma: White Powder

Peso molecolare: 1,301.56 g/mol

Ref: 3D-AP44829

Polymyxin B sulfate, Antibiotic for Culture Media Use Only

CAS: 1405-20-5

Polymyxin B is a sulfonamide antibiotic with broad spectrum of activity against Gram-negative bacteria. It binds to the bacterial membrane, causing an increase in the cell’s permeability and thus leading to cell death. A study on human neutrophils showed that polymyxin B reduces the expression of neomycin sulfate through inhibition of protein synthesis, which leads to cell death by lysosomal enzyme release. This antibiotic has been shown to be effective on clostridium perfringens, where it inhibits bacterial growth and leads to hypersensitivity reactions in some patients.

Formula: C₅₅H₁₀₀N₁₆O₂₁S₂

Purezza: Min. 90.0 Area-%

Peso molecolare: 1,385.61 g/mol

Ref: 3D-P-7010

Polymyxin B Sulphate (Aerosporin, PXNS), 6000U/mg for cell culture, Endotoxin (BET) 1.0EU/mg

CAS: 1405-20-5

Formula: C₅₅H₉₆N₁₆O₁₃·2H₂SO₄

Purezza: min. 6000 units/mg

Colore e forma: White to pale yellow, Powder

Peso molecolare: 1385.61

Ref: SR-52819