CAS 1431641-29-0

(±)-ADX 71743

CAS: 1431641-29-0

(±)-ADX 71743 is a metabotropic glutamate receptor (mGluR) allosteric modulator that increases the activity of the receptor by binding to it. This modulates neurotransmission and reduces pain signals in the central nervous system. (±)-ADX 71743 has been shown to be effective in animal models of nerve injury, sciatic nerve injury, and neuropathic pain. In these models, (±)-ADX 71743 was found to reduce both spontaneous pain and evoked pain responses. It also reduced neuronal hyperexcitability in the dorsal horn of the spinal cord, which is involved in processing nociceptive signals from peripheral tissues. The drug binds to mGluR7 with high affinity, but does not bind to mGluR1 or other subtypes of mGluRs.

Formula: C₁₇H₁₉NO₂

Purezza: Min. 95%

Peso molecolare: 269.34 g/mol

Ref: 3D-GHC64129

ADX71743

CAS: 1431641-29-0

ADX71743 is a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7.

Formula: C₁₇H₁₉NO₂

Colore e forma: Solid

Peso molecolare: 269.34

Ref: TM-T26570