CAS 1433875-14-9

Macitentan Impurity 7

CAS: 1433875-14-9

Formula: C₁₅H₁₇BrN₄O₅S

Colore e forma: White To Off-White Solid

Peso molecolare: 445.29

Ref: 4Z-M-128011

ACT-373898

CAS: 1433875-14-9

ACT-373898 is a metabolite of the endothelin (ET) receptor type A (ETA) and ETBdual antagonist macitentan .1

Formula: C₁₅H₁₇BrN₄O₅S

Colore e forma: Solid

Peso molecolare: 445.29

Ref: TM-T35623

ACT 373898 Disodium Salt

Prodotto controllato

CAS: 1433875-14-9

Stability Hygroscopic
Applications ACT 373898 Disodium Salt is an impurity of Macitentan (M105005), an orally active endothelin receptor antagonist used for pulmonary arterial hypertension.
References Emoto, N. Ensho to Men'eki, 20, 487 (2012); Bruderer, S. et al.: Xenobiotica, 42, 901 (2012);

Formula: C₁₅H₁₅BrN₄Na₂O₅S

Purezza: >85%

Colore e forma: Neat

Peso molecolare: 489.252

Ref: TR-A191600

Act 373898 disodium

CAS: 1433875-14-9

Act 373898 disodium (A37) is a custom synthesis drug product that is used as an analytical standard for the metabolism of actiomycin D. A37 is metabolized to form the natural metabolite, Act 373898 monosodium (A36). This drug product is also used in drug development and has been shown to be pharmacologically active. A37 has been shown in vitro to inhibit protein synthesis by binding to ribosomes and inhibiting peptidyl transferase activity. A37 is not a natural compound but it does possess niche properties. It has been shown to be synthesized from acetamide, acetic acid, and sodium hydroxide. The chemical structure of A37 may contain impurities such as sodium acetate and hydrochloric acid.

Formula: C₁₅H₁₇BrN₄O₅S

Purezza: Min. 95%

Peso molecolare: 445.3 g/mol

Ref: 3D-IHC87514

Macitentan Impurity 7

CAS: 1433875-14-9

Formula: C₁₅H₁₇BrN₄O₅S

Peso molecolare: 445.29

Ref: ST-EA-CP-M5020