CAS 14357-78-9

Diprenorfina

Descrizione:

Diprenorfina è un antagonista oppioide sintetico utilizzato principalmente in medicina veterinaria, in particolare per invertire gli effetti degli analgesici narcotici negli animali. È classificato come un derivato della morfina e presenta un'alta affinità per i recettori oppioidi, in particolare il recettore mu-opioide, che gli consente di contrastare efficacemente gli effetti degli oppioidi. Diprenorfina è noto per la sua potenza, spesso richiedendo solo una piccola dose per ottenere l'effetto antagonista desiderato. La sostanza viene tipicamente somministrata per iniezione ed è utilizzata in situazioni in cui è necessaria una rapida inversione della sedazione oppioide, come nella gestione della fauna selvatica o durante procedure chirurgiche. Il suo profilo farmacologico include una durata d'azione relativamente lunga, il che può essere vantaggioso in alcuni scenari clinici. Tuttavia, si consiglia cautela, poiché può provocare sintomi di astinenza negli animali dipendenti dagli oppioidi. In generale, Diprenorfina è uno strumento critico nella medicina veterinaria per gestire gli effetti degli oppioidi e garantire la sicurezza degli animali trattati.

Formula: C₂₆H₃₅NO₄

InChI: InChI=1S/C26H35NO4/c1-23(2,29)18-13-24-8-9-26(18,30-3)22-25(24)10-11-27(14-15-4-5-15)19(24)12-16-6-7-17(28)21(31-22)20(16)25/h6-7,15,18-19,22,28-29H,4-5,8-14H2,1-3H3/t18-,19-,22-,24-,25+,26-/m1/s1

InChI key: InChIKey=OIJXLIIMXHRJJH-KNLIIKEYSA-N

SMILES: O(C)[C@@]12[C@]3([C@]45[C@@]([C@](N(CC6CC6)CC4)(CC7=C5C(O3)=C(O)C=C7)[H])(C[C@@H]1[C@](C)(C)O)CC2)[H]

Sinonimi:

• (14Beta)-17-(Cyclopropylmethyl)-18-(2-Hydroxypropan-2-Yl)-6-Methoxy-18,19-Dihydro-4,5-Epoxy-6,14-Ethenomorphinan-3-Ol
• (5alpha,6beta,14beta,18R)-17-(cyclopropylmethyl)-18-(2-hydroxypropan-2-yl)-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol
• (5α,7α)-17-(Cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α,α-dimethyl-6,14-ethenomorphinan-7-methanol
• 1-N-Cyclopropylmethyl-6,7,8,14-tetrahydro-6,14-endoethano-7-(2′-hydroxy-2′-propyl)nororipavine
• 21-Cyclopropyl-6,7,8,14-tetrahydro-7alpha-(1-hydroxy-1-methylethyl)-6,14-endo-ethanooripavine
• 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha,alpha-dimethyl-, (5alpha,7alpha)-
• 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α,α-dimethyl-, (5α,7α)-
• 6,14-endo-Ethanotetrahydrooripavine, 21-cyclopropyl-7α-(1-hydroxy-1-methylethyl)-
• DEA No. 9058
• Diprenorfina
• Diprenorfina [INN-Spanish]
• Diprenorphine [INN:BAN]
• Diprenorphinum
• Diprenorphinum [INN-Latin]
• M 5050
• M 5050 Injection
• M50-50
• M50-50 Injection
• N-(Cyclopropylmethyl)-19-methylnororvinol
• Rx 5050M
• Diprenorphine
• Diprenorphine
• 17-(Cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α,α-dimethyl-6,14-ethenomorphinan-7-methanol
• Diprenorphine (base and/or unspecified salts)
• DIPRENORPHINE POTENT OPIOID ANTAGON
• DPN

Diprenorphine

Prodotto controllato

CAS: 14357-78-9

Formula: C₂₆H₃₅NO₄

Colore e forma: Neat

Peso molecolare: 425.56

Ref: 86-MM1384.00

Diprenorphine

Prodotto controllato

CAS: 14357-78-9

Diprenorphine is a synthetic opioid drug that has low potency and high lipid solubility. It is an antagonist at the μ-opioid receptor and an agonist at the κ-opioid receptor. The hydroxyl group on the diprenorphine molecule affects its conformation, which may affect its ability to bind to the μ-opioid receptor. Diprenorphine binds competitively to the κ-opioid receptor, acting as a competitive inhibitor of morphine and other opiates. In addition, it can be used as a substrate for P-glycoprotein (P-gp), which is an important transporter for many drugs in the body. Diprenorphine is not clinically relevant as a pain reliever because it does not have any analgesic effects in humans or animals. Diprenorphine is also used as a radiolabeled probe for positron emission tomography (PET) imaging studies of P-gp activity

Formula: C₂₆H₃₅NO₄

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 425.56 g/mol

Ref: 3D-FD03511

Diprenorphine

CAS: 14357-78-9

Colore e forma: Neat

Ref: 61-FOR1384.00

Diprenorphine

CAS: 14357-78-9

Diprenorphine

Formula: C₂₆H₃₅NO₄

Purezza: 99.4%

Colore e forma: Off-White

Peso molecolare: 425.25661

Ref: 47-589