CAS 14362-31-3

Clorclizina cloridrato

Descrizione:

Clorclizina cloridrato è un antistaminico appartenente alla classe dei diphenylmethane, utilizzato principalmente per le sue proprietà anti-allergiche. È caratterizzato dalla sua capacità di bloccare i recettori dell'istamina H1, alleviando così i sintomi associati a reazioni allergiche, come la febbre da fieno e l'orticaria. Il composto appare come una polvere cristallina bianca o bianco sporco ed è solubile in acqua, rendendolo adatto per varie formulazioni farmaceutiche. Clorclizina cloridrato presenta una durata d'azione relativamente lunga, il che contribuisce alla sua efficacia nella gestione dei sintomi allergici. Inoltre, può avere effetti sedativi, una caratteristica comune tra gli antistaminici di prima generazione, che può portare a sonnolenza in alcuni individui. La sostanza è tipicamente somministrata per via orale ed è disponibile in varie forme di dosaggio, tra cui compresse e sciroppi. Come per qualsiasi farmaco, è essenziale considerare i potenziali effetti collaterali, come secchezza delle fauci, vertigini e disturbi gastrointestinali, e usarlo sotto supervisione medica per garantire sicurezza ed efficacia.

Formula: C₁₈H₂₁ClN₂·ClH

InChI: InChI=1S/C18H21ClN2.ClH/c1-20-11-13-21(14-12-20)18(15-5-3-2-4-6-15)16-7-9-17(19)10-8-16;/h2-10,18H,11-14H2,1H3;1H

InChI key: InChIKey=MSIJLVMSKDXAQN-UHFFFAOYSA-N

SMILES: C(C1=CC=C(Cl)C=C1)(N2CCN(C)CC2)C3=CC=CC=C3.Cl

Sinonimi:

• 1-(P-Chloro-Alpha-Phenylbenzyl)-4-Methyl-Piperazinhydrochloride
• 1-(P-Chloro-Alpha-Phenylbenzyl)-4-Methylpiperazinehydrochloride
• 1-(P-Chlorobenzhydryl)-4-Methylpiperazinehydrochloride
• 1-(p-Chloro-alpha-phenylbenzyl)-4-methylpiperazine hydrochloride
• 1-(p-Chloro-alpha-phenylbenzyl)-4-methylpiperazine monohydrochloride
• 1-[(4-Chlorophenyl)(Phenyl)Methyl]-4-Methylpiperazine
• 1-[(4-Chlorophenyl)(Phenyl)Methyl]-4-Methylpiperazine Hydrochloride (1:1)
• 1-[(4-Chlorophenyl)Phenyl-Methyl]-4-Methylpiperazine Hydrochloride
• Chlorcyclizine HCL
• Chlorcyclizine chloride
• Chlorcyclizine monohydrochloride
• Chlorcycliziniumchloride
• Di-Paralene
• Eramide
• Histantin
• Mantadil
• NSC 169496
• Perazil
• Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-methyl-, hydrochloride
• Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-methyl-, monohydrochloride
• Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-4-methyl-, hydrochloride
• Piperazine, 1-(p-chloro-α-phenylbenzyl)-4-methyl-, monohydrochloride
• Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-methyl-, hydrochloride (1:1)
• Unii-Npb7A7874U

Chlorcyclizine Hydrochloride 1.0 mg/ml in Methanol (as free base)

CAS: 14362-31-3

Colore e forma: Single Solution

Ref: 61-AMP1653.00-01

CHLORCYCLIZINE HYDROCHLORIDE CRS

CAS: 14362-31-3

CHLORCYCLIZINE HYDROCHLORIDE CRS

Formula: C₁₈H₂₂Cl₂N₂

Colore e forma: Crystalline Powder. White. Yellow. Powder.

Peso molecolare: 337.2867

Ref: 41-C1435000

Chlorcyclizine Hydrochloride

Prodotto controllato

CAS: 14362-31-3

Formula: C₁₈H₂₁ClN₂·ClH

Colore e forma: Neat

Peso molecolare: 337.29

Ref: 86-MM1653.00

Chlorcyclizine Hydrochloride

CAS: 14362-31-3

Colore e forma: Neat

Ref: 61-FOR1653.00

Chlorcyclizine HCl

CAS: 14362-31-3

Formula: C₁₈H₂₁ClN₂·HCl

Peso molecolare: 300.83 36.46

Ref: 4Z-C-332001

Chlorcyclizine hydrochloride

Prodotto controllato

CAS: 14362-31-3

Chlorcyclizine hydrochloride is a potent inhibitor of the growth factor-β1 receptor. It also has antimicrobial activity and can be used as an antiseptic, especially for the treatment of eye infections. Chlorcyclizine hydrochloride is a potent inducer of toll-like receptor 4 (TLR4) which is responsible for innate immunity against bacteria and fungi. This drug also inhibits propranolol hydrochloride binding to the β2-adrenergic receptor, which may lead to cardiotoxicity in some patients. The compound has shown significant cytotoxicity on liver cells in vitro, but not on other cell lines; this toxicity may be due to its ability to react with iodides in solution, forming reactive intermediates that cause cellular damage.

Formula: C₁₈H₂₂Cl₂N₂

Purezza: Min. 95 Area-%

Colore e forma: Powder

Peso molecolare: 337.29 g/mol

Ref: 3D-FC178661

Chlor Cyclizine-d4 Dihydrochloride

Prodotto controllato

CAS: 1246911-79-4, 14362-31-3

Formula: C₁₈H₁₇D₄ClN₂•2HCl

Colore e forma: Neat

Peso molecolare: 304.85 + 2(36.46)

Ref: TR-C326504

Chlor Cyclizine Hydrochloride

Prodotto controllato

CAS: 14362-31-3

Applications An antihistaminic drug. A drug analog of Cyclizine (C987805).
References Leurs, R., et al.: Pharmacol. Ther., 66, 413 (1995), Hu, Q., et al.: J. Biol. Chem., 274, 33995 (1999), Church, M., et al.: Clin. Exp. Allergy, 31, 1341 (2001),

Formula: C₁₈H₂₁ClN₂·ClH

Colore e forma: Off-White

Peso molecolare: 337.29

Ref: TR-C326500

Chlorcyclizine hydrochloride

CAS: 14362-31-3

Chlorcyclizine hydrochloride

Formula: C₁₈H₂₂Cl₂N₂

Colore e forma: Off-White

Peso molecolare: 337.2867

Ref: 47-67