CAS 144750-42-5

Composto Correlato A di Clopidogrel USP

Descrizione:

Composto Correlato A di Clopidogrel USP, con il numero CAS 144750-42-5, è una sostanza chimica che è strutturalmente correlata al farmaco antipiastrinico clopidogrel. È caratterizzata principalmente dal suo ruolo come impurità o prodotto di degradazione nella sintesi del clopidogrel. Questo composto è tipicamente identificato attraverso tecniche analitiche come la cromatografia liquida ad alte prestazioni (HPLC) e la spettrometria di massa. La sua struttura molecolare presenta gruppi funzionali specifici che contribuiscono al suo comportamento chimico e stabilità. Il clopidogrel stesso è un pro-farmaco che richiede attivazione metabolica per esercitare i suoi effetti farmacologici, e composti correlati come il Composto A possono mostrare diversi gradi di attività biologica o tossicità. La presenza di tali composti correlati è importante per il controllo qualità nelle formulazioni farmaceutiche, poiché possono influenzare l'efficacia e la sicurezza del prodotto finale. Le linee guida normative spesso dettano i limiti accettabili per queste impurità per garantire la sicurezza del paziente e l'efficacia del farmaco.

Formula: C₁₅H₁₄ClNO₂S·ClH

InChI: InChI=1S/C15H14ClNO2S.ClH/c16-12-4-2-1-3-11(12)14(15(18)19)17-7-5-13-10(9-17)6-8-20-13;/h1-4,6,8,14H,5,7,9H2,(H,18,19);1H/t14-;/m0./s1

InChI key: InChIKey=FOKSIOUPGDBSLC-UQKRIMTDSA-N

SMILES: [C@H](C(O)=O)(N1CC2=C(CC1)SC=C2)C3=C(Cl)C=CC=C3.Cl

Sinonimi:

• (+)-(S)-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid, hydrochloride
• (2S)-(2-Chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride (1:1)
• (S)-2-(2-Chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride
• (αS)-α-(2-Chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid hydrochloride (1:1)
• Clopidogrel Related Compound A
• Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-6,7-dihydro-, hydrochloride (1:1), (αS)-
• Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-6,7-dihydro-, hydrochloride, (αS)-
• Clopidogrel Related Compound A (20 mg) ((S)-(ochlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-aceticv acid, hydrochloride)
• Clopidogrel Impurity 1 HCl(Clopidogrel EP Impurity A HCl)
• CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE)
• Clopidogrel carboxylic acid Impurity
• Clopidogrel USP Related CoMpound A
• Clopidogrel Related Compound A as Hydrochloride
• Clopidogrel Impurity 2/Clopidogrel EP Impurity A HCl/(S)-Clopidogrel Acid Hydrochloride/(S)-2-(2-Chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride
• Clopidogrel USP Related Compound A as Hydrochloride
• alpha-(2-Chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid hydrochloride
• Clopidogrel Hydrogen Sulfate EP Impurity A as Hydrochloride
• (+)-(S)-(o-Chlorophenyl)-6,7-dihydrothieno3,2-cpyridine-5(4H)-acetic acid hydrochloride
• Clopidogrel USP RC A
• Clopidogrel Hydrogen Sulfate Impurity A as Hydrochloride
• (S)-(2-Chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid hydrochloride
• (S)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride? (Clopidogrel Impurity）
• Clopidogrel acid hydrochloride
• Clopidogrel EP Impurity A HCl
• Clopidogrel EP IMpurity-A
• Clopidogrel Related Compound A ((+)-(S)-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-ace (1140586)
• Clopidogrel Carboxylic Acid Hydrochloride Salt
• Clopidogrel Impurity A（EP）
• Clopidogrel Related Compound A (H0M124)
• Clopidogrel EP impurity-A (USP RC A)
• Clopidogrel Carboxylic Acid Hydrochloride

CLOPIDOGREL IMPURITY A CRS

CAS: 144750-42-5

CLOPIDOGREL IMPURITY A CRS

Ref: 41-Y0001335

Clopidogrel Related Compound A ((+)-(S)-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid, hydrochloride)

CAS: 144750-42-5

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₁₅H₁₄ClNO₂S·HCl

Colore e forma: Off-White Powder

Peso molecolare: 307.04338

Ref: 45-1140586

Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-6,7-dihydro-, hydrochloride (1:1), (αS)-

CAS: 144750-42-5

Formula: C₁₅H₁₅Cl₂NO₂S

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 344.2561

Ref: IN-DA001K3J

(S)-2-(2-Chlorophenyl)-2-(6,7-Dihydrothieno[3,2-c]Pyridin-5(4H)-Yl)Acetic Acid Hydrochloride

CAS: 144750-42-5

(S)-2-(2-Chlorophenyl)-2-(6,7-Dihydrothieno[3,2-c]Pyridin-5(4H)-Yl)Acetic Acid Hydrochloride

Purezza: 98%

Peso molecolare: 344.26g/mol

Ref: 54-OR1028086

(2S)-(2-Chlorophenyl)[6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]acetic Acid Hydrochloride (Clopidogrel Acid Hydrochloride)

CAS: 144750-42-5

Colore e forma: Neat

Ref: 86-MM0455.04

(S)-2-(2-Chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride

CAS: 144750-42-5

Purezza: 95.0%

Peso molecolare: 344.25

Ref: 10-F237891

Clopidogrel Carboxylic Acid hydrochloride

CAS: 144750-42-5

Clopidogrel Carboxylic Acid hydrochloride (SR 26334) is a major inactive metabolite of clopidogrel, commonly used as a reference standard for metabolic analysi.

Formula: C₁₅H₁₅Cl₂NO₂S

Purezza: 99.32%

Colore e forma: Solid

Peso molecolare: 344.26

Ref: TM-T36112

Clopidogrel Carboxylic Acid Hydrochloride

Prodotto controllato

CAS: 144750-42-5

Impurity Clopidogrel EP Impurity A; Clopidogrel Impurity A; Clopidogrel USP A
Stability Hygroscopic
Applications Clopidogrel Carboxylic Acid Hydrochloride (Clopidogrel EP Impurity A; Clopidogrel Impurity A; Clopidogrel USP A) is the hydrochloride salt of a metabolite of the drug Clopidogrel.
References Savi, P., et al.: Biochem. Pharmacol., 44, 527 (1992), Pereillo, J., et al.: Drug Metab. Dispos., 30, 1288 (2002), Ksycinska, H., et al.: J. Pharm. Biomed. Anal., 41, 533 (2006), Farid, N., et al.: Clin. Pharmacol. Ther., 81, 735 (2007),

Formula: C₁₅H₁₄ClNO₂S·ClH

Colore e forma: Light Yellow

Peso molecolare: 344.26

Ref: TR-C587235

(R)- Clopidogrel Carboxylic Acid Hydrochloride

Prodotto controllato

CAS: 144750-42-5

Formula: C₁₅H₁₄ClNO₂S·HCl

Colore e forma: Neat

Peso molecolare: 344.26

Ref: TR-C587231

Clopidogrel Impurity A

CAS: 144750-42-5

Clopidogrel Impurity A is a medicine that is used for the prevention of heart attacks, strokes, and blood clots in people with an increased risk of these events. It is not intended to be used for immediate relief from sudden symptoms. Clopidogrel Impurity A is a substance that may be found in some preparations of clopidogrel. The presence of this substance can be detected by liquid chromatography-mass spectrometry (LC-MS/MS) methods. The structural analysis of this substance was determined using enantiomeric resolution and chromatographic methods. This impurity has been shown to have no effect on the bioavailability of the parent drug, clopidogrel, when given orally to Sprague-Dawley rats.

Formula: C₁₅H₁₅Cl₂NO₂S

Purezza: Min. 95%

Peso molecolare: 344.26 g/mol

Ref: 3D-IC158706