CAS 145877-52-7

CP 122721 dihydrochloride

CAS: 145877-52-7

CP 122721 is a potent inhibitor of p-glycoprotein (p-gp) and may be used as an anticancer agent. CP 122721 is able to inhibit the activity of p-gp, which is a transporter protein that pumps out anticancer drugs from cells. CP 122721 also has a partitioning coefficient, which means it can bind to both water and lipid membrane bilayers. This drug also exhibits linear pharmacokinetics in humans, which means that its concentration in the blood remains constant over time. CP 122721 also binds to proteins in the blood, including albumin and lipoproteins, which are proteins that carry cholesterol and fats in the blood. The binding of CP 122721 to these proteins reduces its concentration in the blood and slows down its elimination from the body.

Formula: C₂₀H₂₃F₃N₂O₂·2HCl

Purezza: Min. 95%

Peso molecolare: 453.33 g/mol

Ref: 3D-BC166438

CP 122721 hydrochloride

CAS: 145877-52-7

CP 122721 hydrochloride is a potent and selective non-peptide (nonpeptide) neurokinin NK1 antagonist, demonstrating a pIC50 of 9.8 against the human NK1 receptor in IM-9 cells. It exhibits anxiolytic and antidepressant-like effects, as evidenced in studies [1] [2].

Formula: C₂₀H₂₅Cl₂F₃N₂O₂

Colore e forma: Solid

Peso molecolare: 453.33

Ref: TM-T84898