CAS 14636-12-5

Terlipressina

Descrizione:

Terlipressina è un analogo sintetico della vasopressina, un ormone peptidico che si verifica naturalmente. È utilizzato principalmente in contesti clinici per le sue proprietà vasocostrittrici, in particolare nella gestione di condizioni come il sanguinamento variceale esofageo e lo shock settico. Terlipressina agisce sui recettori V1, portando a un aumento della resistenza vascolare e a una riduzione del flusso sanguigno verso determinati organi, il che può aiutare a stabilizzare la pressione sanguigna. La sostanza viene tipicamente somministrata per via endovenosa e ha una emivita relativamente lunga rispetto alla vasopressina, consentendo una somministrazione meno frequente. Terlipressina è caratterizzata dalla sua capacità di indurre contrazione della muscolatura liscia, in particolare nella circolazione splancnica, il che è utile nel controllo dell'ipertensione portale. La sua struttura chimica include una sequenza peptidica modificata che ne migliora stabilità e potenza. Sebbene generalmente ben tollerata, gli effetti collaterali potenziali possono includere ipertensione, dolore addominale ed eventi ischemici, richiedendo un attento monitoraggio durante il trattamento. In generale, Terlipressina è un agente terapeutico critico in terapia intensiva e gastroenterologia.

Formula: C₅₂H₇₄N₁₆O₁₅S₂

InChI: InChI=1/C52H74N16O15S2/c53-17-5-4-9-31(45(76)60-23-41(57)72)63-51(82)38-10-6-18-68(38)52(83)37-27-85-84-26-36(61-44(75)25-59-43(74)24-58-42(73)22-54)50(81)65-34(20-29-11-13-30(69)14-12-29)48(79)64-33(19-28-7-2-1-3-8-28)47(78)62-32(15-16-39(55)70)46(77)66-35(21-40(56)71)49(80)67-37/h1-3,7-8,11-14,31-38,69H,4-6,9-10,15-27,53-54H2,(H2,55,70)(H2,56,71)(H2,57,72)(H,58,73)(H,59,74)(H,60,76)(H,61,75)(H,62,78)(H,63,82)(H,64,79)(H,65,81)(H,66,77)(H,67,80)/t31-,32-,33-,34-,35-,36-,37-,38-/m0/s1

SMILES: c1ccc(cc1)C[C@H]1C(=N[C@@H](CCC(=N)O)C(=N[C@@H](CC(=N)O)C(=N[C@@H](CSSC[C@@H](C(=N[C@@H](Cc2ccc(cc2)O)C(=N1)O)O)N=C(CN=C(CN=C(CN)O)O)O)C(=O)N1CCC[C@H]1C(=N[C@@H](CCCCN)C(=NCC(=N)O)O)O)O)O)O

Sinonimi:

• N-(N-(N-Glycylglycyl)Glycyl)-8-L-Lysinevasopressin
• (2S)-1-[(4S,7S,10S,13S,16S,19S)-19-[[2-[[2-[(2-Aminoacetyl)Amino]Acetyl]Amino]Acetyl]Amino]-13-Benzyl-10-(2-Carbamoylethyl)-7-(Carbamoylmethyl)-16-[(4-Hydroxyphenyl)Methyl]-6,9,12,15,18-Pentaoxo-1,2-Dithia-5,8,11,14,17-Pentazacycloicosane-4-Carbonyl]-N-[(1S)-5-Amino-1-(Carbamoylmethylcarbamoyl)Pentyl]Pyrrolidine-2-Carboxamide
• (2S)-1-{[(4R,7S,10S,13S,16S,19R)-19-{[({[(aminoacetyl)amino]acetyl}amino)acetyl]amino}-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-N-{(2S)-6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl}pyrrolidine-2-carboxamide (non-preferred name)
• Terlipressin Acetate
• [N-α-Triglycyl-8-lysine]-vasopressin
• 1-Triglycyl-8-lysine vasopressin
• Glycylpressin
• Glypressin
• Nα-Glycyl-glycyl-glycyl-[8-lysine]-vasopressin
• Nα-Glycyl-glycyl-glycyl-lysine-vasopressin
• Nα-Glycylglycylglycyl-vasopressin
• Nα-Gly-Gly-Gly-8-Lys-vasopressin
• Remestyp
• Terlipressina
• Terlipressine
• Triglycyl-8-lysine-vasopressin
• Vasopressin, N-(glycylglycylglycyl)-8-L-lysine-

Terlipressin

CAS: 14636-12-5

Terlipressin is a synthetic analog of vasopressin which is used as a vasoactive drug in the management of hypotension. It acts as a prodrug, as it is converted to (Lys⁸)-vasopressin by removal of the N-terminal triglycine in vivo. This vasopressin analog has a longer duration of action and a better safety profile than the parent compound. Terlipressin has found application in the management of acute variceal hemorrhage (esophageal varices), hepatorenal syndrome, and norepinephrine-resistant septic shock.

Formula: C₅₂H₇₄N₁₆O₁₅S₂

Purezza: ≥ 98%

Colore e forma: White

Peso molecolare: 1227.39

Ref: 01-4061053

TERLIPRESSIN FOR NMR IDENTIFICATION CRS

CAS: 14636-12-5

TERLIPRESSIN FOR NMR IDENTIFICATION CRS

Formula: C₅₂H₇₄N₁₆O₁₅S₂

Peso molecolare: 1227.372

Ref: 41-Y0001898

TERLIPRESSIN CRS

CAS: 14636-12-5

TERLIPRESSIN CRS

Formula: C₅₂H₇₄N₁₆O₁₅S₂

Peso molecolare: 1227.372

Ref: 41-Y0001897

Terlipressin acetate

CAS: 14636-12-5

Formula: C₅₂H₇₄N₁₆O₁₅S₂

Peso molecolare: 1227.37

Ref: 7W-GP3216

Terlipressin

CAS: 14636-12-5

Formula: C₅₂H₇₄N₁₆O₁₅S₂

Colore e forma: White To Off-White Solid

Peso molecolare: 1227.38

Ref: 4Z-PT-150001

Terlipressin

CAS: 14636-12-5

Terlipressin is a potent vasoconstrictor that acts via V1 receptors on arteriolar smooth muscle cells.

Formula: C₅₂H₇₄N₁₆O₁₅S₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 1227.37

Ref: TM-T13920

Terlipressin Acetate

CAS: 14636-12-5

Formula: C₅₂H₇₄N₁₆O₁₅S₂

Purezza: 95%~99%

Colore e forma: White to Off-white Powder

Peso molecolare: 1227.37

Ref: BP-BPPG063

Terlipressin-Phe(d5) Diacetate Salt

Prodotto controllato

CAS: 14636-12-5

Applications Isotope labelled Terlipressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. Terlipressin is used norepinephrine-resistant septic shock and hepatorenal syndrome. Terlipressin is also used in the treatment of acute variceal bleeding.
References Uriz, J. et al.: J. Heptol., 33, 43 (2000); O'Brien, A. et al.: Lancet, 359, 1209 (2002); Burroughs, A.K. et al.: Digestion, 59, 26 (1998); Villanueva, C. et al.: Am. J. Gastroenterol., 100, 624 (2005);

Formula: C₅₆H₇₇D₅N₁₆O₁₉S₂

Colore e forma: Off White Solid

Peso molecolare: 1352.5

Ref: TR-T115802

D-Gln(7)-Terlipressin Trifluoroacetic Acid Salt

Prodotto controllato

CAS: 14636-12-5

Applications D-Gln(7)-Terlipressin is an impurity of Terlipressin (Diacetate Salt :T115800) which is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. Terlipressin is used norepinephrine-resistant septic shock and hepatorenal syndrome.
References Uriz, J. et al.: J. Heptol., 33, 43 (2000); O'Brien, A. et al.: Lancet, 359, 1209 (2002); Burroughs, A.K. et al.: Digestion, 59, 26 (1998); Villanueva, C. et al.: Am. J. Gastroenterol., 100, 624 (2005);

Formula: C₅₂H₇₄N₁₆O₁₅S₂•x(C₂HF₃O₂)

Colore e forma: Neat

Peso molecolare: 1227.37 + x(114.02)

Ref: TR-G410180

D-Cys(4)-Terlipressin Trifluoroacetic Acid Salt

Prodotto controllato

CAS: 14636-12-5

Applications D-Cys(4)-Terlipressin is an impurity of Terlipressin (Diacetate Salt :T115800) which is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. Terlipressin is used norepinephrine-resistant septic shock and hepatorenal syndrome.
References Uriz, J. et al.: J. Heptol., 33, 43 (2000); O'Brien, A. et al.: Lancet, 359, 1209 (2002); Burroughs, A.K. et al.: Digestion, 59, 26 (1998); Villanueva, C. et al.: Am. J. Gastroenterol., 100, 624 (2005);

Formula: C₅₂H₇₄N₁₆O₁₅S₂•x(C₂HF₃O₂)

Colore e forma: Neat

Peso molecolare: 1227.3711402

Ref: TR-C997840