CAS 146478-72-0

(2Z,4S)-4-(Acetilossi)-N-[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4,7-diidrossi-7-metil-1,6-diospiro[2.5]ott-5-il]-3-metil-2,4-pentadien-1-il]tetraidro-2,5-dimetil-2H-pirano-3-il]-2-pentenamide

Descrizione:

La sostanza chimica con il nome "(2Z,4S)-4-(Acetilossi)-N-[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4,7-diidrossi-7-metil-1,6-diospiro[2.5]ott-5-il]-3-metil-2,4-pentadien-1-il]tetraidro-2,5-dimetil-2H-pirano-3-il]-2-pentenamide" e numero CAS "146478-72-0" è un composto organico complesso caratterizzato da molteplici gruppi funzionali e stereocentri. Presenta un gruppo acetyloxy, il che suggerisce una reattività e solubilità potenziale nei solventi organici. La presenza di una struttura dioxaspiro indica un arrangiamento ciclico unico che può contribuire alla sua attività biologica. Il composto contiene anche più centri chirali, che possono influenzare la sua stereochimica e le interazioni con i sistemi biologici. La sua struttura suggerisce potenziali applicazioni in ambito farmaceutico o come composto bioattivo, sebbene specifiche attività biologiche richiederebbero ulteriori indagini. L'intricato arrangiamento di catene di carbonio e gruppi funzionali evidenzia la sua complessità, rendendolo un argomento di interesse nella chimica organica sintetica e nella ricerca in chimica medicinale.

Formula: C₂₇H₄₁NO₈

InChI: InChI=1S/C27H41NO8/c1-16(8-11-23-25(31)27(15-33-27)14-26(6,32)36-23)7-10-22-17(2)13-21(19(4)35-22)28-24(30)12-9-18(3)34-20(5)29/h7-9,11-12,17-19,21-23,25,31-32H,10,13-15H2,1-6H3,(H,28,30)/b11-8+,12-9-,16-7+/t17-,18-,19+,21+,22-,23+,25+,26-,27+/m0/s1

InChI key: InChIKey=PJKVJJDQXZARCA-QHYZBLTGSA-N

SMILES: O[C@H]1[C@]2(CO2)C[C@@](C)(O)O[C@@H]1/C=C/C(=C/C[C@H]3[C@@H](C)C[C@@H](NC(/C=C\[C@@H](OC(C)=O)C)=O)[C@@H](C)O3)/C

Sinonimi:

• 2-Pentenamide, 4-(acetyloxy)-N-[6-[5-(4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl)-3-methyl-2,4-pentadienyl]tetrahydro-2,5-dimethyl-2H-pyran-3-yl]-, [3R-[3R*,4R*,5R*[1[2R*,3R*(2Z,4S*),5S*,6S*],2E,4E],7S*]]-
• (2Z,4S)-4-(Acetyloxy)-N-[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl]-3-methyl-2,4-pentadien-1-yl]tetrahydro-2,5-dimethyl-2H-pyran-3-yl]-2-pentenamide
• WB 2663B
• 2-Pentenamide, 4-(acetyloxy)-N-[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl]-3-methyl-2,4-pentadienyl]tetrahydro-2,5-dimethyl-2H-pyran-3-yl]-, (2Z,4S)-
• 2-Pentenamide, 4-(acetyloxy)-N-[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl]-3-methyl-2,4-pentadien-1-yl]tetrahydro-2,5-dimethyl-2H-pyran-3-yl]-, (2Z,4S)-

FR901464

CAS: 146478-72-0

FR901464 (WB 2663B) is potent cytotoxic natural products that share an amine-containing tetrahydropyran ring.

Formula: C₂₇H₄₁NO₈

Purezza: 98.47%

Colore e forma: Solid

Peso molecolare: 507.62

Ref: TM-T31866

FR901464

CAS: 146478-72-0

FR901464

Purezza: ≥98%

Peso molecolare: 507.62g/mol

Ref: 54-BUP01121

FR 901464

CAS: 146478-72-0

FR 901464 is a cytotoxic compound that inhibits the activity of the mammalian splicing factor receptor (SFRS2), which is involved in the splicing process. The active form of FR 901464 binds to SFRS2 and prevents it from binding to other proteins, thereby inhibiting the formation of functional complexes. This leads to an increase in the production of proteins that are not targeted for degradation and a decrease in the production of proteins targeted for degradation. This drug also has anti-inflammatory properties by inhibiting epidermal growth factor (EGF) and its receptor, EGF-R. It also has antimicrobial effects against some bacteria by inhibiting bacterial growth factors such as amide or conjugates.

Formula: C₂₇H₄₁NO₈

Purezza: Min. 95%

Peso molecolare: 507.6 g/mol

Ref: 3D-WFA47872