CAS 146629-34-7

Uridine, 2'-deoxy-5-(trimethylstannyl)-

CAS: 146629-34-7

Formula: C₁₂H₂₀N₂O₅Sn

Colore e forma: Solid

Peso molecolare: 390.9986

Ref: IN-DA001E6R

5-(Trimethylstannyl)-2''-deoxyuridine

CAS: 146629-34-7

Ref: 7W-GC2019

5-(Trimethylstannyl)-2'-deoxyuridine

Prodotto controllato

CAS: 146629-34-7

Applications Several novel 5-substituted 2'-deoxyuridine (dUrd) analogs were evaluated as substrates for highly purified herpes simplex virus type 1 (HSV-1)-encoded thymidine kinase (TK) derived from HSV-1 TK gene-transfected murine mammary carcinoma FM3A cells, and human platelet thymidine (dThd) phosphorylase.
References Bohman, C., et al.: J. Biol. Chem., 269, 8036 (1994),

Formula: C₁₂H₂₀N₂O₅Sn

Colore e forma: Neat

Peso molecolare: 391.01

Ref: TR-T797200

5-(Trimethylstannyl)-2'-deoxyuridine

CAS: 146629-34-7

5-(Trimethylstannyl)-2'-deoxyuridine is a nucleoside analogue that is structurally related to thymidine. It has been shown to be cytotoxic in vitro, with high cytotoxicity for human glioma cells. This drug has been detected in vivo using autoradiography and microspectrophotometry, with a maximum uptake in the brain and detectable levels in the kidneys and liver. 5-(Trimethylstannyl)-2'-deoxyuridine is taken up by cells through an energy transfer process. The drug is demercurated from the cell surface by extracellular enzymes, such as sulfatases and phosphatases, converting it into 5-mercapto-2'-deoxyuridine (MdUrd), which can be detected by its UV-absorption characteristics.

Formula: C₁₂H₂₀N₂O₅Sn

Purezza: Min. 95%

Peso molecolare: 391.01 g/mol

Ref: 3D-NT16878