CAS 146897-68-9

Lattoferricina B

Descrizione:

Lattoferricina B è un peptide derivato dalla lattoferrina, una glicoproteina presente in vari fluidi secretori, incluso il latte. È noto per le sue proprietà antimicrobiche, mostrando attività contro un ampio range di batteri, funghi e virus. La struttura di Lattoferricina B consiste in una sequenza di amminoacidi che contribuiscono alla sua capacità di interrompere le membrane microbiche, portando alla lisi cellulare. Questo peptide è anche riconosciuto per i suoi effetti immunomodulatori, migliorando la risposta immunitaria e potenzialmente giocando un ruolo nella regolazione dell'infiammazione. Inoltre, Lattoferricina B è stato studiato per le sue potenziali applicazioni nella conservazione degli alimenti e come agente terapeutico nel trattamento delle infezioni. La sua stabilità in diverse condizioni di pH e la resistenza agli enzimi proteolitici aumentano ulteriormente la sua utilità sia in ambito clinico che nell'industria alimentare. In generale, Lattoferricina B rappresenta un'area significativa di interesse in biochimica e farmacologia grazie alle sue proprietà multifunzionali e ai potenziali benefici per la salute.

Formula: C₁₄₁H₂₂₄N₄₆O₂₉S₃

InChI: InChI=1/C141H226N46O29S3/c1-11-77(6)111(133(212)186-112(80(9)189)134(213)183-106(74-218)130(209)184-110(76(4)5)132(211)176-97(49-32-61-161-141(155)156)120(199)170-93(45-28-57-157-137(147)148)116(195)166-78(7)113(192)180-103(136(215)216)66-82-36-16-13-17-37-82)185-128(207)104(72-188)181-131(210)107-50-33-62-187(107)135(214)79(8)165-109(191)71-164-115(194)100(64-75(2)3)177-121(200)92(44-24-27-56-144)168-117(196)91(43-23-26-55-143)169-125(204)99(53-63-219-10)175-119(198)94(46-29-58-158-138(149)150)172-126(205)101(67-83-69-162-88-40-20-18-38-85(83)88)179-124(203)98(51-52-108(146)190)174-127(206)102(68-84-70-163-89-41-21-19-39-86(84)89)178-122(201)96(48-31-60-160-140(153)154)171-118(197)95(47-30-59-159-139(151)152)173-129(208)105(73-217)182-123(202)90(42-22-25-54-142)167-114(193)87(145)65-81-34-14-12-15-35-81/h12-21,34-41,69-70,75-80,87,90-107,110-112,162-163,188-189,217-218H,11,22-33,42-68,71-74,142-145H2,1-10H3,(H2,146,190)(H,164,194)(H,165,191)(H,166,195)(H,167,193)(H,168,196)(H,169,204)(H,170,199)(H,171,197)(H,172,205)(H,173,208)(H,174,206)(H,175,198)(H,176,211)(H,177,200)(H,178,201)(H,179,203)(H,180,192)(H,181,210)(H,182,202)(H,183,213)(H,184,209)(H,185,207)(H,186,212)(H,215,216)(H4,147,148,157)(H4,149,150,158)(H4,151,152,159)(H4,153,154,160)(H4,155,156,161)/t77-,78-,79-,80+,87-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,110-,111-,112-/m0/s1

Sinonimi:

• L-Phenylalanine, L-phenylalanyl-L-lysyl-L-cysteinyl-L-arginyl-L-arginyl-L-tryptophyl-L-glutaminyl-L-tryptophyl-L-arginyl-L-methionyl-L-lysyl-L-lysyl-L-leucylglycyl-L-alanyl-L-prolyl-L-seryl-L-isoleucyl-L-threonyl-L-cysteinyl-L-valyl-L-arginyl-L-arginyl-L-alanyl-
• Lactoferrin
• Lfn B

Lactoferricin B25

CAS: 146897-68-9

The antimicrobial peptide lactoferricin B25 is a fragment of cow’s milk protein lactoferrin. The peptide exhibits potent dose-dependent and time-dependent anticancer activity against human stomach cancer cell cultures via apoptosis and autophagy. LFcinB25 is expected to yield novel anticancer drugs.

Formula: C₁₄₁H₂₂₄N₄₆O₂₉S₃

Purezza: > 95%

Colore e forma: White Powder

Peso molecolare: 3123.82

Ref: 01-4087382

Lactoferrin, from bovine milk

CAS: 146897-68-9

Ref: 7W-GX6595

Lactoferrin (17-41)

CAS: 146897-68-9

Amino acids 17-41 of lactoferrin, lactoferricin B, enhance anti-fungal effects, targeting Candida Albicans.

Formula: C₁₄₁H₂₂₄N₄₆O₂₉S₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 3123.77

Ref: TM-TP1518

Lactoferrin (17-41) (Standard)

CAS: 146897-68-9

Lactoferrin (17-41) (Standard) is a reference material for analytical use. Lactoferrin (17-41) exhibits broad-spectrum antimicrobial activity.

Formula: C₁₄₁H₂₂₄N₄₆O₂₉S₃

Peso molecolare: 3123.77

Ref: TM-TMSM-1421

Lactoferrin

Prodotto controllato

CAS: 146897-68-9

Applications Lactoferrin is a multifunctional protein of transferin family. A glycoprotein present in various secretions including milk, saliva and tears. Antiviral agent, it binds to liproproteins of cell membranes dispersing virus molecules from host cells.
References Sánchez L. et al.: Arch. Dis. CHild., 67, 657 (1992); Harmsen MC. et al.: J. Infect. Dis., 172, 380 (1995);

Formula: C₁₄₁H₂₂₄N₄₆O₂₉S₃

Colore e forma: Neat

Peso molecolare: 3123.8

Ref: TR-L113780

Lactoferrin

CAS: 146897-68-9

Lactoferrin is a multifunctional glycoprotein, which is primarily sourced from bovine milk, human milk, and other mammalian secretions. With its high affinity for iron, lactoferrin sequesters iron ions, which inhibits bacterial growth by depriving them of the iron necessary for proliferation. This mechanism enables lactoferrin to exhibit potent antimicrobial properties.

Formula: C₁₄₁H₂₂₄N₄₆O₂₉S₃

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 3,123.8 g/mol

Ref: 3D-FL181256

Lactoferricin B25

CAS: 146897-68-9

Lactoferricin B25 is a potent anticancer agent that has shown significant activity in vitro against cancer cell lines. It has been shown to induce apoptosis and autophagy, which are both methods of inducing cell death. Lactoferricin B25 also induces caspase-mediated apoptosis and has been shown to be effective in the treatment of cancer cells in vivo. Lactoferricin B25 binds with high affinity to the cell membrane, which is thought to be responsible for its anticancer activity. The half-maximal inhibitory concentration (IC50) for this compound is about 2 μM, with a concomitant cytotoxic effect at 10 μM. Lactoferricin B25 binds to DNA polymerase, preventing DNA replication and transcription. The binding of lactoferricin B25 to DNA polymerase inhibits the synthesis of RNA from DNA templates by inhibiting the elongation step of transcription.

Formula: C₁₄₁H₂₂₄N₄₆O₂₉S₃

Purezza: Min. 90 Area-%

Colore e forma: Powder

Peso molecolare: 3,123.78 g/mol

Ref: 3D-FL110082