CAS 147-94-4

Citarabina

Descrizione:

Citarabina, noto anche come arabinoside di citosina, è un analogo di nucleoside utilizzato principalmente come agente antineoplastico nel trattamento di alcuni tipi di leucemia e linfoma. La sua formula chimica è C9H13N3O5 e presenta un gruppo zuccherino (arabinoside) legato a una base di citosina. Citarabina è caratterizzato dalla sua capacità di inibire la sintesi del DNA, rendendolo efficace nel colpire le cellule cancerose che si dividono rapidamente. Viene tipicamente somministrato per iniezione, poiché è scarsamente assorbito se assunto per via orale. Il composto è noto per la sua emivita relativamente breve, che richiede infusione continua o dosaggi frequenti in contesti clinici. Gli effetti collaterali comuni includono mielosoppressione, che può portare a una maggiore suscettibilità a infezioni e emorragie, oltre a disturbi gastrointestinali. A causa del suo meccanismo d'azione, Citarabina è spesso utilizzato in combinazione con altri agenti chemioterapici per migliorare l'efficacia terapeutica. Il suo uso è attentamente monitorato, dato il potenziale di tossicità significativa, in particolare nei pazienti con condizioni preesistenti o quelli che ricevono terapie concomitanti.

Formula: C₉H₁₃N₃O₅

InChI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1

InChI key: InChIKey=UHDGCWIWMRVCDJ-CCXZUQQUSA-N

SMILES: O[C@@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)N=C(N)C=C2

Sinonimi:

• (Arabinofuranosyl)cytosine
• 1-(Arabinofuranosyl)cytosine
• 1-(β-<span class="text-smallcaps">D</span>-Arabinofuranosyl)cytosine
• 1-(β-D-Arabinofuranosyl)cytosine
• 1-b-D-Arabinofuranosylcytosine
• 1-β-<span class="text-smallcaps">D</span>-Arabinosylcytosine
• 1-β-Arabinofuranosylcytosine
• 1-β-D-Arabinosylcytosine
• 2(1H)-Pyrimidinone, 4-amino-1-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-
• 2(1H)-Pyrimidinone, 4-amino-1-β-D-arabinofuranosyl-
• 4-Amino-1-Beta-D-Arabinofuranosyl-2(1H)-Pyrimidinone
• 4-Amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
• 4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidine
• 4-Amino-1-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-2(1H)-pyrimidinone
• 4-Amino-1-β-D-Arabinofuranosyl-2(1H)-pyrimidinone
• 4-amino-1-(D-arabinofuranosyl)pyrimidin-2(1H)-one
• 4-amino-1-(beta-D-arabinofuranosyl)pyrimidin-2(1H)-one
• 4-amino-1-[(2R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one
• 4-amino-1-pentofuranosylpyrimidin-2(1H)-one
• Ac 1075
• Alexan
• Ara-C
• Ara-cell
• ArabinoFuranosylcytosine
• Arabinocytidine
• Arabinocytosine
• Arabinoside C
• Arabitin
• Aracytidine
• Aracytin
• Aracytine
• Arafcyt
• Chx 3311
• Citarabina
• Citozar
• Cyclocide
• Cylocide
• Cylocide N
• Cytarabin
• Cytarabine
• Cytarabinoside
• Cytosar
• Cytosar U
• Cytosine Arabinoside
• Cytosine β-<span class="text-smallcaps">D</span>-arabinofuranoside
• Cytosine β-<span class="text-smallcaps">D</span>-arabinoside
• Cytosine β-D-arabinofuranoside
• Cytosine β-D-arabinoside
• Cytosine, 1-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-
• Cytosine, 1-β-D-arabinofuranosyl-
• Cytosine-1-β-<span class="text-smallcaps">D</span>-arabinofuranoside
• Cytosine-1-β-D-arabinofuranoside
• Cytosine-1-β-arabinofuranoside
• DepoCyt
• DepoCyte
• Erpalfa
• Iretin
• Mk 8242
• N-(2-oxo-2,3-dihydropyrimidin-4-yl)-D-arabinofuranosylamine
• Nsc 287459
• Nsc 63878
• Sch 900242
• Spongocytidine
• Tarabine PFS
• U 19920
• U 19920A
• Udicil
• ara-Cytosine

CYTARABINE RS

CAS: 147-94-4

CYTARABINE RS

Formula: C₉H₁₃N₃O₅

Peso molecolare: 243.2166

Ref: 41-ICRS46472

CYTARABINE CRS

CAS: 147-94-4

CYTARABINE CRS

Formula: C₉H₁₃N₃O₅

Colore e forma: Added Modified

Peso molecolare: 243.2166

Ref: 41-C3350000

Cytarabine

CAS: 147-94-4

Cytarabine

Formula: C₉H₁₃N₃O₅

Purezza: 99.9%

Colore e forma: White

Peso molecolare: 243.08552

Ref: 47-383

Cytarabine

CAS: 147-94-4

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₉H₁₃N₃O₅

Colore e forma: White Off-White Powder

Peso molecolare: 243.08552

Ref: 45-1162002

4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one

CAS: 147-94-4

Formula: C₉H₁₃N₃O₅

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 243.2166

Ref: IN-DA0034OE

Cytarabine

CAS: 147-94-4

Cytarabine (Ara-C) is a nucleoside analog, an inhibitor of DNA synthesis (IC50=16 nM).

Formula: C₉H₁₃N₃O₅

Purezza: 99.83% - 99.93%

Colore e forma: Fine Off-White Crystalline Powder

Peso molecolare: 243.22

Ref: TM-T1272

Cytosine-β-D-arabinofuranoside

CAS: 147-94-4

Cytosine-β-D-arabinofuranoside

Formula: C₉H₁₃N₃O₅

Purezza: 98%

Colore e forma: white crystalline powder

Peso molecolare: 243.22g/mol

Ref: 54-OR1012751

Cytarabine-13C-15N2

CAS: 147-94-4

Formula: C₈₁₃CH₁₃N₁₅N₂O₅

Colore e forma: White To Off-White Solid

Peso molecolare: 246.20

Ref: 4Z-C-150002

Cytarabine

CAS: 147-94-4

Formula: C₉H₁₃N₃O₅

Purezza: 98.0 - 102.0 % (dried basis)

Colore e forma: White crystalline powder

Peso molecolare: 243.22

Ref: 7W-GP6403

Cytarabine

CAS: 147-94-4

Formula: C₉H₁₃N₃O₅

Colore e forma: White To Off-White Solid

Peso molecolare: 243.22

Ref: 4Z-C-150007

Cytarabine

CAS: 147-94-4

Cytarabine

Purezza: ≥98%

Peso molecolare: 243.22g/mol

Ref: 54-BUP17828

Arabinocytosine

CAS: 147-94-4

Formula: C₉H₁₃N₃O₅

Purezza: 95%~99%

Peso molecolare: 243.219

Ref: BP-BP3887

Cytarabine

CAS: 147-94-4, 69-74-9

Formula: C₉H₁₃N₃O₅

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 243.22

Ref: 3B-C2035

Cytarabine

CAS: 147-94-4

Formula: C₉H₁₃N₃O₅

Colore e forma: Neat

Peso molecolare: 243.22

Ref: 04-C11926000

Cytarabine

Prodotto controllato

CAS: 147-94-4

Formula: C₉H₁₃N₃O₅

Colore e forma: Neat

Peso molecolare: 243.22

Ref: 86-MM1117.00

Cytarabine-13C3

CAS: 147-94-4

Formula: C₆₁₃C₃H₁₃N₃O₅

Peso molecolare: 246.19

Ref: 4Z-C-150001

Cytarabine

CAS: 147-94-4

Applications Cytarabine is used as an antineoplastic and antiviral. It is a selective inhibitor of DNA synthesis. Does not inhibit RNA synthesis.Cytarabine, or cytosine arabinoside, is a chemotherapy agent used mainly in the treatment of cancers of white blood cells such as acute myeloid leukemia (AML) and non-Hodgkin lymphoma. It is also known as Ara-C (Arabinofuranosyl Cytidine). It destroys cancer cells by interfering with DNA synthesis.
References Donehower, R.C., et al.: Cancer Treat. Rep., 70, 1059 (1986);

Formula: C₉H₁₃N₃O₅

Colore e forma: Neat

Peso molecolare: 243.22

Ref: TR-C998100

Cytarabine-13C3

Prodotto controllato

CAS: 147-94-4

Stability Hygroscopic
Applications Labelled Cytarabine, a compound used as an antineoplastic and antiviral. A selective inhibitor of DNA synthesis. Does not inhibit RNA synthesis.
References Donehower, R.C., et al.: Cancer Treat. Rep., 70, 1059 (1986)

Formula: C₆₁₃C₃H₁₃N₃O₅

Colore e forma: Beige

Peso molecolare: 246.19

Ref: TR-C998102

Cytarabine

CAS: 147-94-4

Anti-viral; anti-neoplastic

Formula: C₉H₁₃N₃O₅

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 243.22 g/mol

Ref: 3D-NA05771

Cytarabine - Bio-X ™

CAS: 147-94-4

Cytarabine is also known as cytosine arabinoside (ara-C) and is a chemotherapy drug that works by inhibiting DNA synthesis. It acts as a nucleoside analogue, which is incorporated into the growing DNA chain during replication. Cytarabine combines a cytosine base with an arabinose sugar (1β-arabinofuranosylcytosine) and is an analog for human deoxycytosine. Cytarabine interferes with DNA synthesis as it is rapidly converted to cytosine arabinoside triphosphate, damaging DNA when cells are in the synthesis phase (S phase). Tumor cells which are highly mitotic and growing rapidly are therefore preferably targeted. Cytarabine also inhibits nucleotide reductase enzymes as well as nuclear polymerases, leading to interruption and inhibition of synthesis, strand breaks and cell death.

Formula: C₉H₁₃N₃O₅

Purezza: (%) Min. 98%

Colore e forma: Powder

Peso molecolare: 243.22 g/mol

Ref: 3D-BA164339