CAS 147059-72-1

Trovafloxacina

Descrizione:

Trovafloxacina è un antibiotico fluoroquinolone sintetico che mostra un'attività antibatterica ad ampio spettro. È utilizzato principalmente per trattare varie infezioni batteriche, in particolare quelle causate da organismi Gram-positivi e Gram-negativi. Il composto agisce inibendo la girasi del DNA batterico e la topoisomerasi IV, enzimi critici per la replicazione e la trascrizione del DNA, impedendo così la divisione e la crescita cellulare batterica. Trovafloxacina è caratterizzato dalla sua potenza relativamente alta contro alcuni patogeni, inclusi quelli resistenti ad altri antibiotici. Viene tipicamente somministrato per via orale o endovenosa e ha un profilo farmacocinetico favorevole, consentendo una somministrazione una volta al giorno in molti casi. Tuttavia, il suo uso è stato limitato a causa di preoccupazioni riguardanti la epatotossicità e il potenziale per effetti collaterali gravi, portando al suo ritiro dal mercato in alcune regioni. Inoltre, come altre fluoroquinoloni, può essere associato a rischi di rottura dei tendini e effetti sul sistema nervoso centrale. In generale, sebbene Trovafloxacina dimostri proprietà antibatteriche efficaci, il suo profilo di sicurezza richiede una considerazione attenta nell'uso clinico.

Formula: C₂₀H₁₅F₃N₄O₃

InChI: InChI=1/C20H15F3N4O3/c21-8-1-2-15(13(22)3-8)27-7-12(20(29)30)17(28)9-4-14(23)19(25-18(9)27)26-5-10-11(6-26)16(10)24/h1-4,7,10-11,16H,5-6,24H2,(H,29,30)/t10-,11+,16+

InChI key: InChIKey=WVPSKSLAZQPAKQ-CDMJZVDBNA-N

SMILES: O=C1C=2C(N(C=C1C(O)=O)C3=C(F)C=C(F)C=C3)=NC(=C(F)C2)N4C[C@]5([C@@](C4)([C@@H]5N)[H])[H]

Sinonimi:

• (1α,5α,6α)-7-(6-Amino-3-azabi-cyclo[3.1.0]hex-3-y1)-1-(2,4-difluomphenyl)-6-fluom-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
• 1,8-Naphthyridine-3-carboxylic acid, 7-(1.alpha.,5.alpha.,6.alpha.)-6-amino-3-azabicyclo3.1.0hex-3-yl-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-
• 1,8-Naphthyridine-3-carboxylic acid, 7-[(1α,5α,6α)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-
• 3-Azabicyclo[3.1.0]hexane, 1,8-naphthyridine-3-carboxylic acid deriv.
• 7-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
• 7-[(1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
• Cp-99219
• Trovan：CP-99219-27
• Turvel
• Trovafloxacin
• 7-[(1R,5S)-6-azanyl-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid
• 7-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid

1,8-Naphthyridine-3-carboxylic acid, 7-[(1α,5α,6α)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-

CAS: 147059-72-1

Formula: C₂₀H₁₅F₃N₄O₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 416.3533

Ref: IN-DA001EKY

Trovafloxacin

CAS: 147059-72-1

Trovafloxacin

Purezza: ≥98%

Ref: 54-BUP22454

Trovafloxacin

CAS: 147059-72-1

Formula: C₂₀H₁₅F₃N₄O₃

Peso molecolare: 416.35

Ref: 7W-GP2666

Trovafloxacin

CAS: 147059-72-1

Trovafloxacin, a broad-spectrum quinolone antibiotic, exhibits potent activity against Gram-positive bacteria.

Formula: C₂₀H₁₅F₃N₄O₃

Purezza: 99.21% - 99.27%

Colore e forma: Solid

Peso molecolare: 416.35

Ref: TM-T13231

Trovafloxacin

Prodotto controllato

CAS: 147059-72-1

Applications Trovafloxacin is a fluroquinolone antibiotic, recently identified as an inhibitor of pannexin-1 (Panx1) channels. Trovafloxacin attenuates neuroinflammation and improves outcome after traumatic brain injury in mice.
References Garg, C., et al.: J. Neuroinflammation, 15, 42 (2018); Angus, J. A., et al.: Eur. J. Pharmacol., 791, 179 (2016)

Formula: C₂₀H₁₅F₃N₄O₃

Colore e forma: Neat

Peso molecolare: 402.37

Ref: TR-T892760

(1R,5R,6R)-7-(6-Amino-3-Azabicyclo[3.1.0]Hex-3- Yl)-1-(2,4-difluorophenyl)-6-Fluoro-1,4-dihydro-4-Oxo-1,8-naphthyridine-3-carbox

CAS: 147059-72-1

The mechanism of action of ciprofloxacin is to bind to the bacterial ribosome, thereby inhibiting protein synthesis. Ciprofloxacin is a broad-spectrum antibiotic that has been shown to be effective against both gram-positive and gram-negative bacteria, including methicillin resistant Staphylococcus aureus (MRSA). Ciprofloxacin is also active against Mycobacterium tuberculosis and Mycobacterium avium complex. It binds to the 30S ribosomal subunit, preventing attachment of aminoacyl tRNA. The addition of tetracycline can increase the activity of ciprofloxacin by inhibiting the efflux pump in the bacterial cell membrane. Ciprofloxacin has been found to have synergistic effects when used in combination with trovafloxacin or other antibiotics that act on different targets.

Formula: C₂₀H₁₅F₃N₄O₃

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 416.35 g/mol

Ref: 3D-FA103840