CAS 147118-39-6

Metile (3R,6E)-7-[4-(4-fluorofenile)-6-(1-metiletil)-2-[metil(metilsulfonil)amino]-5-pirimidinil]-3-idrossi-5-osso-6-eptenoato

Descrizione:

Metile (3R,6E)-7-[4-(4-fluorofenile)-6-(1-metiletil)-2-[metil(metilsulfonil)amino]-5-pirimidinil]-3-idrossi-5-osso-6-eptenoato, con numero CAS 147118-39-6, è un composto organico complesso caratterizzato dalla sua stereochimica specifica e dai gruppi funzionali. Questa sostanza presenta un anello di pirimidina, che è un eterociclo aromatico a sei membri contenente atomi di azoto, contribuendo alla sua attività biologica. La presenza di un gruppo fluorofenile aumenta la sua lipofilia e le potenziali interazioni con bersagli biologici. Il gruppo metilsulfonilamino suggerisce possibili applicazioni in chimica medicinale, in particolare nel design di farmaci, grazie alla sua capacità di modulare le vie biologiche. La porzione heptenoato indica che ha insaturazione, il che può influenzare la sua reattività e stabilità. In generale, la struttura unica di questo composto può conferire proprietà farmacologiche specifiche, rendendolo di interesse nello sviluppo di agenti terapeutici. Tuttavia, sarebbero necessari studi dettagliati per chiarire completamente la sua attività biologica e le potenziali applicazioni.

Formula: C₂₃H₂₈FN₃O₆S

InChI: InChI=1S/C23H28FN3O6S/c1-14(2)21-19(11-10-17(28)12-18(29)13-20(30)33-4)22(15-6-8-16(24)9-7-15)26-23(25-21)27(3)34(5,31)32/h6-11,14,18,29H,12-13H2,1-5H3/b11-10+/t18-/m1/s1

InChI key: InChIKey=ULUNETUXUVEFLH-DOJUMQAQSA-N

SMILES: C(=C/C(C[C@H](CC(OC)=O)O)=O)\C=1C(=NC(N(S(C)(=O)=O)C)=NC1C(C)C)C2=CC=C(F)C=C2

Sinonimi:

• (3R,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3-hydroxy-5-oxo-6-heptenoic acid methyl ester
• 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3-hydroxy-5-oxo-, methyl ester, (3R,6E)-
• 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3-hydroxy-5-oxo-, methyl ester, [R-(E)]-
• H-2
• Methyl (3R,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3-hydroxy-5-oxo-6-heptenoate
• Methyl 7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R)-3-hydroxy-5-oxo-(E)-6-heptenate
• Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesul fonylamino) pyrimidin-5-yl]-3-hydroxy-5-oxo-6(E)-heptenoate
• Methyl-(+)-(3R)-7-[4-(4- fluorophenyl)-6-isopropyl-2-(N-methyl-N-Methansul phonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-6(E)-heptenoate
• Methyl-(+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-(methansulphonyl amino)pyrimidin-5-yl]-3-hydroxy-5-oxo-6(E)-heptenoate
• methyl (3R,6E)-7-{4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-hydroxy-5-oxohept-6-enoate

Methyl (+)-(3r)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(n-methyl-n-methanesulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6e)-heptenoate

CAS: 147118-39-6

Formula: C₂₃H₂₈FN₃O₆S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 493.5483

Ref: IN-DA001EMZ

5-Oxorosuvastatin methyl ester

CAS: 147118-39-6

5-Oxorosuvastatin methyl ester

Purezza: 98%

Peso molecolare: 493.56g/mol

Ref: 54-PC1007820

5-Oxorosuvastatin Methyl Ester

Prodotto controllato

CAS: 147118-39-6

Formula: C₂₃H₂₈FN₃O₆S

Colore e forma: Neat

Peso molecolare: 493.55

Ref: 86-MM0936.03

5-Oxorosuvastatin Methyl Ester

CAS: 147118-39-6

Applications 5-Oxorosuvastatin methyl ester is an intermediate in the synthesis of Rosuvasatatin (calcium salt: R700500), a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that decreases high-sensitivity C-reactive protein (hsCRP) and cholesterol concentrations in the blood.
References McTaggart, F., et al.: Am. J. Cardiol., 87, 28 (2001); Ridker, P., et al.: Lancet, 373, 1175 (2009)

Formula: C₂₃H₂₈FN₃O₆S

Colore e forma: Yellow Solid

Peso molecolare: 493.55

Ref: TR-O862005

Rosuvastatin 5-Oxo Acid Methyl Ester

CAS: 147118-39-6

Formula: C₂₃H₂₈FN₃O₆S

Peso molecolare: 493.55

Ref: ST-EA-CP-R1048