CAS 1476-52-4

(±)-Desetilclorochina

Descrizione:

(±)-Desetilclorochina è un composto chimico che è un derivato della cloroquina, noto principalmente per il suo utilizzo come agente antimalarico. Questa sostanza è caratterizzata dalla sua modifica strutturale, in particolare dalla rimozione del gruppo etile dalla molecola di cloroquina. Presenta proprietà che possono influenzare la sua attività farmacologica, inclusi potenziali effetti antivirali. Il composto ha un centro chirale, che porta all'esistenza di enantiomeri, che possono mostrare diverse attività biologiche. (±)-Desetilclorochina è solubile in solventi organici e ha una solubilità limitata in acqua, il che può influenzare la sua biodisponibilità e l'efficacia terapeutica. Si pensa che il suo meccanismo d'azione coinvolga l'interferenza con il processo di polimerizzazione dell'eme nei parassiti della malaria, così come una possibile modulazione delle risposte immunitarie. La ricerca sulla sua farmacocinetica, profilo di sicurezza e applicazioni terapeutiche continua, in particolare nel contesto delle malattie infettive emergenti. Come per molti composti farmaceutici, comprendere le sue caratteristiche è cruciale per sviluppare protocolli di trattamento efficaci.

Formula: C₁₆H₂₂ClN₃

InChI: InChI=1S/C16H22ClN3/c1-3-18-9-4-5-12(2)20-15-8-10-19-16-11-13(17)6-7-14(15)16/h6-8,10-12,18H,3-5,9H2,1-2H3,(H,19,20)

InChI key: InChIKey=MCYUUUTUAAGOOT-UHFFFAOYSA-N

SMILES: N(C(CCCNCC)C)C=1C2=C(N=CC1)C=C(Cl)C=C2

Sinonimi:

• (±)-Desethylchloroquine
• 1,4-Pentanediamine N4-(7-chloro-4-quinolinyl)-N1-ethyl-
• 1,4-Pentanediamine, N⁴-(7-chloro-4-quinolinyl)-N¹-ethyl-
• 4-[[1-Methyl-4-((ethylamino)butyl]amino)]-7-chloroquinoline
• 7-Chloro-4-(4-N-ethylamino-1-methylbutylamino)quinoline
• Chloroquine, deethyl-
• Deethylchloroquine
• Monodeethylchloroquine
• Monodesethylchloroquine
• N-Deethylchloroquine
• N4-(7-Chloro-4-quinolinyl)-N1-ethyl-1,4-pentanediamine
• N⁴-(7-Chloro-4-quinolinyl)-N¹-ethyl-1,4-pentanediamine
• Nsc 13254
• N~4~-(7-chloroquinolin-4-yl)-N~1~-ethylpentane-1,4-diamine
• Quinoline, 7-chloro-4-[[4-(ethylamino)-1-methylbutyl]amino]-

Chloroquine Related Compound D (7-Chloro-4-{[4-(ethylamino)-1-methylbutyl] amino} quinoline)

CAS: 1476-52-4

Compounds (excluding drugs and pesticides) containing a quinoline or isoquinoline ring-system (whether or not hydrogenated) not further fused, nesoi

Formula: C₁₆H₂₂ClN₃

Colore e forma: Tan Powder

Peso molecolare: 291.15023

Ref: 45-1118350

1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1-ethyl-

CAS: 1476-52-4

Formula: C₁₆H₂₂ClN₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 291.8190

Ref: IN-DA001F0N

Desethyl chloroquine

CAS: 1476-52-4

Desethyl chloroquine

Purezza: ≥98%

Peso molecolare: 291.82g/mol

Ref: 54-BUP17493

Hydroxychloroquine Sulfate EP Impurity D HBr (Chloroquine USP Related Compound D HBr, Desethyl Chloroquine HBr)

CAS: 1476-52-4

Formula: C₁₆H₂₂ClN₃·HBr

Colore e forma: White To Off-White Solid

Peso molecolare: 291.82 80.91

Ref: 4Z-H-0640

Hydroxychloroquine Sulfate EP Impurity D (Chloroquine USP Related Compound D, Desethyl Chloroquine)

CAS: 1476-52-4

Formula: C₁₆H₂₂ClN₃

Colore e forma: White To Off-White Solid

Peso molecolare: 291.82

Ref: 4Z-H-0638

Desethyl chloroquine

CAS: 1476-52-4

Desethyl chloroquine (Monodesethylchloroquine) is a major metabolite of Chloroquine which is a TLR inhibitor. Desethyl chloroquine shows antiplasmodic activity.

Formula: C₁₆H₂₂ClN₃

Purezza: 99.56%

Colore e forma: Solid

Peso molecolare: 291.82

Ref: TM-T11001

Hydroxychloroquine Sulfate EP Impurity D DiHBr (Chloroquine USP Related Compound D DiHBr, Desethyl Chloroquine DiHBr)

CAS: 1476-52-4

Formula: C₁₆H₂₂ClN₃·2HBr

Colore e forma: White To Off-White Solid

Peso molecolare: 291.82 2*80.91

Ref: 4Z-H-0618

Hydroxychloroquine Sulfate EP Impurity D TriHCl (Chloroquine USP Related Compound D TriHCl, Desethyl Chloroquine TriHCl)

CAS: 1476-52-4

Formula: C₁₆H₂₂ClN₃·3HCl

Peso molecolare: 291.83 3*36.46

Ref: 4Z-H-0665

Desethyl Chloroquine

Prodotto controllato

CAS: 1476-52-4

Applications Desethyl Chloroquine is the major product of the stereoselective human metabolism of Chloroquine, used for the therapy and prevention of malaria. It is a COVID19-related research product.
References Essien, E., et al.: J. Pharm. Pharmacol., 38, 543 (1986), Akintonwa, A., et al.: Ther. Drug Monit., 10, 147 (1988), Boelaert, J., et al.: AIDS, 15, 2205 (2001), Basco, L., et al.: Antimicrob. Agents Chemother., 47, 1391 (2003),

Formula: C₁₆H₂₂ClN₃

Colore e forma: Light Yellow To Dark Yellow

Peso molecolare: 291.82

Ref: TR-D288735

Desethyl chloroquine

CAS: 1476-52-4

Desethyl chloroquine is a drug that is used to treat malaria and other infectious diseases. It is an antimalarial drug that has been shown to be effective in the treatment of malaria and related diseases such as toxoplasmosis, amebiasis, trypanosomiasis, and leishmaniasis. Methods for the preparation of desethyl chloroquine are described in the analytical section. To measure the concentration of desethyl chloroquine in blood, it is recommended to collect a sample of blood by venipuncture or fingerstick. The concentration-time curve in blood can be analyzed using a fluorescence detector and LC-MS/MS method. When analyzing pharmacokinetic properties, it is important to take into account the matrix effect due to human serum proteins. Desethyl chloroquine has potent inducers that affect its pharmacokinetics and metabolism, including CYP3A4 enzymes and glutathione reductase.

Formula: C₁₆H₂₂ClN₃

Purezza: Min. 95%

Colore e forma: Slightly Yellow Powder

Peso molecolare: 291.82 g/mol

Ref: 3D-FD21174