CAS 1476-53-5

Novobiocina sodica

Descrizione:

Novobiocina sodica, con il numero CAS 1476-53-5, è un composto antibiotico che appartiene alla classe dei derivati della cumarina. È principalmente derivato dal batterio *Streptomyces niveus* e presenta proprietà antibatteriche, in particolare contro i batteri Gram-positivi. La novobiocina agisce inibendo la girasi del DNA batterico, un enzima critica per la replicazione e trascrizione del DNA, interrompendo così la crescita batterica. La forma di sale sodico ne migliora la solubilità in soluzioni acquose, rendendola adatta per varie applicazioni farmaceutiche. Oltre alla sua attività antibatterica, la novobiocina è stata studiata per il suo potenziale utilizzo nella terapia contro il cancro grazie alla sua capacità di inibire determinati processi cellulari. Il composto viene tipicamente somministrato in un contesto clinico ed è soggetto a linee guida specifiche per il dosaggio a causa dei suoi effetti farmacologici. I profili di sicurezza ed efficacia sono considerazioni essenziali nel suo utilizzo, come per qualsiasi antibiotico, per prevenire lo sviluppo di resistenza e garantire risultati terapeutici ottimali.

Formula: C₃₁H₃₆N₂O₁₁·Na

InChI: InChI=1S/C31H36N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37);/t23-,25+,26-,29-;/m1./s1

InChI key: InChIKey=BZFOBLOAMAJKQV-RNROJPEYSA-N

SMILES: CC1=C2C(C(O)=C(NC(=O)C3=CC(CC=C(C)C)=C(O)C=C3)C(=O)O2)=CC=C1O[C@H]4[C@H](O)[C@H](OC(N)=O)[C@@H](OC)C(C)(C)O4.[Na]

Sinonimi:

• (3R,4S,5R,6R)-5-hydroxy-6-[(2-hydroxy-3-{[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzoyl]amino}-8-methyl-4-oxo-4H-chromen-7-yl)oxy]-3-methoxy-2,2-dimethyltetrahydro-2H-pyran-4-yl carbamate (non-preferred name)
• 5-hydroxy-6-[(2-hydroxy-3-{[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzoyl]amino}-8-methyl-4-oxo-4H-chromen-7-yl)oxy]-3-methoxy-2,2-dimethyltetrahydro-2H-pyran-4-yl carbamate (non-preferred name)
• Albamycin
• Albamycin (capsule)
• Albamycin sodium
• Benzamide, N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-buten-1-yl)-, sodium salt (1:1)
• Benzamide, N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-butenyl)-, monosodium salt
• Cathomycin sodium
• Cathomycin sodium lyovac
• Monosodium novobiocin
• N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl}-4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamide
• NSC 2382
• Novobiocin Sodium
• Novobiocin Sodium Crystalline
• Novobiocin Sodium Usp
• Novobiocin monosodium
• Novobiocin, monosodium salt
• Novobiocin, sodium deriv.
• Sodium albamycin
• Sodium novobiocin
• Vulcamycin
• sodium 7-{[(2R,3R,4S,5R)-4-(carbamoyloxy)-3-hydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3-({[4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl]carbonyl}amino)-8-methyl-2-oxo-2H-chromen-4-olate (non-preferred name)
• Benzamide, N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-α-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-butenyl)-, monosodium salt

Novobiocin sodium salt

CAS: 1476-53-5

Novobiocin sodium salt, 1476-53-5, is an antibiotic compound produced by Streptomyces nieveus which inhibits topoisomerase II. Learn more at Thermo Fisher Scientific.

Formula: C₃₁H₃₅N₂NaO₁₁

Colore e forma: White to pale cream to yellow, Powder

Peso molecolare: 634.61

Ref: 02-J60928

Novobiocin Sodium

CAS: 1476-53-5

Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound.

Formula: C₃₁H₃₅N₂NaO₁₁

Purezza: 99% - 99.28%

Colore e forma: Solid

Peso molecolare: 634.61

Ref: TM-T0974

Novobiocin Sodium Salt

CAS: 1476-53-5

Formula: C₃₁H₃₅N₂NaO₁₁

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 634.6062

Ref: IN-DA00AOT3

Novobiocin Sodium

CAS: 1476-53-5

Novobiocin Sodium

Purezza: ≥98%

Peso molecolare: 634.61g/mol

Ref: 54-BUP11826

Novobiocin sodium salt

CAS: 1476-53-5

Novobiocin sodium salt

Formula: C₃₁H₃₅N₂O₁₁·Na

Purezza: By hplc: 96.2% by area (Typical Value in Batch COA)

Colore e forma: off white powder

Peso molecolare: 634.60617g/mol

Ref: 54-BIN0394

Novobiocin sodium salt

CAS: 1476-53-5

Formula: C₃₁H₃₅N₂NaO₁₁

Purezza: ≥ 95.0% (dried basis)

Colore e forma: White to off-white powder

Peso molecolare: 634.61

Ref: 7W-GA5711

Novobiocin sodium salt, USP grade

CAS: 1476-53-5

Formula: C₃₁H₃₅N₂NaO₁₁

Purezza: ≥ 90.0%

Colore e forma: White to off-white powder

Peso molecolare: 634.61

Ref: 7W-GP5629

Novobiocin sodium

Prodotto controllato

CAS: 1476-53-5

Formula: C₃₁H₃₅N₂O₁₁·Na

Colore e forma: Neat

Peso molecolare: 634.61

Ref: 04-C15654200

Novobiocin Sodium Salt

Prodotto controllato

CAS: 1476-53-5

Stability Hygroscopic
Applications Novobiocin is an antibiotic that acts as an inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Studies show that Novobiocin is also an inhibitor of retrovirus RNA-dependent DNA-polymerase. Novobiocin is used in the production of positively supercoiled plasmid DNA.
References Cozarelli, N.R.: Science, 207, 953 (1980); Sumiyoshi, Y. et al.: J. Gen. Virol., 64, 2329 (1983); Lockshon, G. et al.: Nucleic Acids Res., 11, 2999 (1983);

Formula: C₃₁H₃₅N₂O₁₁·Na

Colore e forma: Neat

Peso molecolare: 634.61

Ref: TR-N888500

Novobiocin sodium salt, Antibiotic for Culture Media Use Only

CAS: 1476-53-5

Novobiocin sodium salt inhibits bacterial growth by binding to the 50S subunit of the bacterial ribosome, blocking the peptidyl transferase activity required for protein synthesis. The drug binds to DNA sequences containing glucuronic acid, which are essential for peptide bond formation. Novobiocin sodium can be found in pharmaceuticals due to its antimicrobial activity and membrane stability, which makes it suitable for pressuring ionization techniques. It also exhibits less resistance than other antibiotics like triclosan or nalidixic acid because it does not typically bind to the membranes of cells.

Formula: C₃₁H₃₅N₂NaO₁₁

Purezza: Min. 90.0 Area-%

Peso molecolare: 634.61 g/mol

Ref: 3D-N-9100

Novobiocin sodium

CAS: 1476-53-5

Inhibitor of prokaryotic DNA gyrase, eukaryotic DNA topoisomerase and HSP90

Formula: C₃₁H₃₅N₂NaO₁₁

Purezza: Min. 94%

Colore e forma: Powder

Peso molecolare: 634.61 g/mol

Ref: 3D-EN15775

Novobiocin Sodium Salt (NVB), 95%

CAS: 1476-53-5

Formula: C₃₁H₃₅N₂NaO₁₁

Purezza: min. 95%

Colore e forma: White to pale yellow, Powder, Clear

Peso molecolare: 634.61

Ref: SR-27434