CAS 147664-63-9

Pexiganan

Descrizione:

Pexiganan è un peptide antimicrobico sintetico che viene utilizzato principalmente per le sue proprietà antibatteriche, in particolare contro i batteri Gram-negativi. È derivato dalla famiglia di peptidi magainina, che si trovano naturalmente nella pelle di alcuni anfibi. Pexiganan mostra un ampio spettro di attività, rendendolo efficace nel trattamento delle infezioni, specialmente in formulazioni topiche per ferite. Il meccanismo d'azione implica l'interruzione delle membrane cellulari batteriche, portando alla lisi cellulare. Questo peptide è caratterizzato dalle sue dimensioni relativamente piccole, che consistono tipicamente in circa 22 aminoacidi, e dalla sua natura cationica, che migliora la sua interazione con le membrane batteriche caricate negativamente. Pexiganan è anche notevole per la sua stabilità e resistenza alla degradazione proteolitica, il che contribuisce alla sua efficacia nelle applicazioni cliniche. Il suo sviluppo si è concentrato particolarmente sull'affrontare la crescente preoccupazione per la resistenza agli antibiotici, fornendo un approccio alternativo alle terapie antibiotiche tradizionali. In generale, Pexiganan rappresenta un candidato promettente nel campo degli agenti antimicrobici, in particolare per uso topico.

Formula: C₁₂₂H₂₁₀N₃₂O₂₂

InChI: InChI=1/C122H210N32O22/c1-13-77(9)102(152-98(155)71-132)120(174)135-73-100(157)139-86(50-26-35-59-125)110(164)150-96(69-82-44-20-16-21-45-82)118(172)148-93(66-74(3)4)116(170)145-90(54-30-39-63-129)113(167)142-87(51-27-36-60-126)109(163)137-79(11)105(159)141-88(52-28-37-61-127)112(166)143-91(55-31-40-64-130)114(168)149-95(68-81-42-18-15-19-43-81)107(161)134-72-99(156)138-85(49-25-34-58-124)108(162)136-80(12)106(160)147-97(70-83-46-22-17-23-47-83)119(173)153-101(76(7)8)121(175)146-92(56-32-41-65-131)115(169)154-103(78(10)14-2)122(176)151-94(67-75(5)6)117(171)144-89(53-29-38-62-128)111(165)140-84(104(133)158)48-24-33-57-123/h15-23,42-47,74-80,84-97,101-103H,13-14,24-41,48-73,123-132H2,1-12H3,(H2,133,158)(H,134,161)(H,135,174)(H,136,162)(H,137,163)(H,138,156)(H,139,157)(H,140,165)(H,141,159)(H,142,167)(H,143,166)(H,144,171)(H,145,170)(H,146,175)(H,147,160)(H,148,172)(H,149,168)(H,150,164)(H,151,176)(H,152,155)(H,153,173)(H,154,169)/t77-,78-,79-,80-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,101-,102-,103-/m0/s1

SMILES: CC[C@H](C)[C@@H](C(=NCC(=N[C@@H](CCCCN)C(=N[C@@H](Cc1ccccc1)C(=N[C@@H](CC(C)C)C(=N[C@@H](CCCCN)C(=N[C@@H](CCCCN)C(=N[C@@H](C)C(=N[C@@H](CCCCN)C(=N[C@@H](CCCCN)C(=N[C@@H](Cc1ccccc1)C(=NCC(=N[C@@H](CCCCN)C(=N[C@@H](C)C(=N[C@@H](Cc1ccccc1)C(=N[C@@H](C(C)C)C(=N[C@@H](CCCCN)C(=N[C@@H]([C@@H](C)CC)C(=N[C@@H](CC(C)C)C(=N[C@@H](CCCCN)C(=N[C@@H](CCCCN)C(=N)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C(CN)O

Sinonimi:

• Pexiganan [INN]
• Glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-lysyl-L-lysyl-L-alanyl-L-lysyl-L-lysyl-L-phenylalanylglycyl-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-L-lysyl-L-isoleucyl-L-leucyl-L-lysyl-L-lysinamide
• Magainin I, 7-L-lysine-8-L-lysine-10-L-lysine-18-L-lysine-19-de-L-glutamic acid-21-L-leucine-23-L-lysinamide
• L-Lysinamide, glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-lysyl-L-lysyl-L-alanyl-L-lysyl-L-lysyl-L-phenylalanylglycyl-L-lysyl-L-alanyl-L-phenylaalanyl-L-valyl-L-lysyl-L-isoleucyl-L-leucyl-L-lysyl-

Pexiganan

CAS: 147664-63-9

Pexiganan, a synthetic magainin 2 analog, is a broad-spectrum antimicrobial peptide for researching infections like diabetic foot ulcers.

Formula: C₁₂₂H₂₁₀N₃₂O₂₂

Colore e forma: Solid

Peso molecolare: 2477.17

Ref: TM-T73653

Pexiganan

CAS: 147664-63-9

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formula: C₁₂₂H₂₁₀N₃₂O₂₂

Peso molecolare: 2,477.21 g/mol

Ref: 3D-PP50033

Pexiganan

CAS: 147664-63-9

Pexiganan is a polymyxin B derivative that has potent antimicrobial activity against both Gram-positive and Gram-negative bacteria. It has been shown to be effective in the treatment of tissue infections, especially those caused by human pathogens such as Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Pexiganan also has significant activity against Mycobacterium tuberculosis and other mycobacteria. The mechanism of action for pexiganan is not fully understood but it may involve the inhibition of bacterial cell wall synthesis, or the disruption of bacterial membranes. Pexiganan was originally isolated from a marine sponge off the coast of Australia in 1961. It had been classified as an antimicrobial peptide (AMP) because of its chemical structure, which includes a polymyxin B moiety. Pexiganan’s AMP classification was later challenged when researchers found that it did

Formula: C₁₂₂H₂₁₀N₃₂O₂₂

Purezza: Min. 95%

Peso molecolare: 2,477.18 g/mol

Ref: 3D-FP138116

Pexiganan acetate

Prodotto controllato

CAS: 147664-63-9

Pexiganan acetate is the acetate salt form of a polymyxin B derivative that has potent antimicrobial activity against both Gram-positive and Gram-negative bacteria. It has been shown to be effective in the treatment of tissue infections, especially those caused by human pathogens such as Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Pexiganan also has significant activity against Mycobacterium tuberculosis and other mycobacteria. The mechanism of action for pexiganan is not fully understood but it may involve the inhibition of bacterial cell wall synthesis, or the disruption of bacterial membranes. Pexiganan was originally isolated from a marine sponge off the coast of Australia in 1961. It had been classified as an antimicrobial peptide (AMP) because of its chemical structure, which includes a polymyxin B moiety. Pexiganan’s AMP classification was later challenged when researchers found that it did

Formula: C₁₂₂H₂₁₀N₃₂O₂₂•(C₂H₄O₂)x

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 2,477.18 g/mol

Ref: 3D-FP182746