CAS 147794-23-8

omega-conotossina mviic

Descrizione:

L'omega-conotossina MVIIA è un peptide derivato dal veleno della lumaca Conus, specificamente dal Conus magus. È un potente e selettivo bloccante dei canali del calcio voltaggio-dipendenti di tipo N (VGCC), che svolgono un ruolo cruciale nel rilascio di neurotrasmettitori e nella segnalazione del dolore. Questa caratteristica rende l'omega-conotossina MVIIA di grande interesse in farmacologia, in particolare per le sue potenziali applicazioni nella gestione del dolore e nella ricerca neurologica. Il peptide consiste in una sequenza specifica di amminoacidi che contribuisce alla sua struttura e funzione uniche. Mostra alta affinità per i canali del calcio di tipo N, inibendo l'ingresso di calcio e riducendo così il rilascio di neurotrasmettitori, il che può alleviare il dolore. L'omega-conotossina MVIIA è anche studiata per i suoi potenziali effetti terapeutici in vari disturbi neurologici. A causa della sua origine da organismi marini, rappresenta un esempio affascinante di come i prodotti naturali possano portare allo sviluppo di nuovi agenti farmacologici. La sua stabilità e specificità la rendono uno strumento prezioso sia nella ricerca che nelle potenziali applicazioni cliniche.

Formula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Sinonimi:

• w-Conotoxin MVIIC, Conus magus
• H-Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-NH2 (Disulfide bonds between Cys1 and Cys16/Cys8 and Cys20/ Cys15 and Cys26)
• H-Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-Nh2
• H-Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-Nh2 (Disulfide Bridge: 1-16, 8-20, And 15-26)
• Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-Nh2
• Ckgkgapcrktmydccsgscgrrgkc-Nh2 (Disulfide Bridge: 1-16,8-20 And 15-26)
• Omega-Cgtx Mviic
• Omega-Conotoxin Mviic, Conus Magus

ω-Conotoxin MVIIC

CAS: 147794-23-8

Like ω-conotoxin GVIA, this Conus magus peptide inhibits presynaptic Ca²⁺ channels. However, ω-conotoxin MVIIC clearly inhibits additional Ca²⁺ channel subtypes in the mammalian central nervous system. Thus, it should become a standard pharmacological reagent for investigating synaptic transmission in the mammalian nervous system.

Formula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Purezza: > 98%

Colore e forma: White Powder

Peso molecolare: 2749.29

Ref: 01-4030522

ω-Conotoxin MVIIC

CAS: 147794-23-8

Peptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels.

Formula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Purezza: 98%

Colore e forma: White Lyophilised Solid

Peso molecolare: 2749

Ref: TM-TP2064

ω-Conotoxin MVIIC

CAS: 147794-23-8

Formula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Peso molecolare: 2749.25

Ref: 7W-GK3612

Omega-Conotoxin MVIIC

CAS: 147794-23-8

Omega-Conotoxin MVIIC is a peptide that binds to the nicotinic acetylcholine receptor and activates it, leading to inhibition of neurotransmitter release. It is used as a research tool for studying the pharmacology of ion channels and their ligands. Omega-Conotoxin MVIIC is purified from Conus magus venom. The peptide has been shown to be an inhibitor of potassium channels in rat cortical neurons. CONOTOXINS are small peptides that bind to the nicotinic acetylcholine receptor and activate it, leading to inhibition of neurotransmitter release. They are used as research tools for studying the pharmacology of ion channels and their ligands. CONOTOXINS are purified from Conus magus venom. The peptide has been shown to be an inhibitor of potassium channels in rat cortical neurons.END> END>

Formula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Purezza: Min. 95%

Peso molecolare: 2,749.3 g/mol

Ref: 3D-PCN-4283-S

ω-Conotoxin MVIIC

CAS: 147794-23-8

Omega-conotoxins are a group of peptides found in the venom of predatory marine snails. Omega-conotoxin MVIIC is a potent inhibitor of nicotinic acetylcholine receptors. It blocks the activation and desensitization of nicotinic acetylcholine receptor channels and has been used as a research tool to study the function of these proteins. Omega-conotoxin MVIIC binds to its target by interacting with specific sites on the alpha subunit of nicotinic acetylcholine receptor channels, which leads to inhibition of voltage-gated calcium channels. The high purity and low endotoxin levels make this product suitable for life science research applications.

Formula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Purezza: Min. 95%

Peso molecolare: 2,749.3 g/mol

Ref: 3D-PCN-4283-V

Omega-Conotoxin MVIIC

Prodotto controllato

CAS: 147794-23-8

Omega-Conotoxin MVIIC is a peptide toxin that blocks the voltage-dependent calcium channels. It has been shown to have neuroprotective properties and to inhibit glutamate induced neurotoxicity in vitro and in vivo. Omega-Conotoxin MVIIC inhibits neurotransmitter release by blocking the calcium channels and thereby reduces oxidative stress, which prevents neuronal cell death. This toxin also blocks the activity of voltage-dependent sodium channels, but its effects are not as potent as those on calcium channels. Omega-Conotoxin MVIIC has been found to be effective against cerebellar granule neurons, as well as other neurons in the brainstem, cerebellum, hippocampus, and cerebral cortex. The molecular weight of this toxin is approximately 10 kDa and it contains subunits (a total of eight).

Formula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 2,749.26 g/mol

Ref: 3D-FC110353